Stability of Neuroendocrine and Behavioral Responsiveness in Aging Fischer 344/Brown-Norway Hybrid Rats
Aging in rodents and primates is accompanied by changes in hypothalamic-pituitary-adrenal (HPA) activity. We examined behavioral and neuroendocrine responses in 3, 15-, and 30-month-old F344/Brown-Norway rats. Basal corticosterone and ACTH levels did not differ with age, although ACTH responses, but...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2005-07, Vol.146 (7), p.3105-3112 |
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| creator | Kasckow, John W Segar, Tracy M Xiao, Chun Furay, Amy R Evanson, Nathan K Ostrander, Michelle M Herman, James P |
| description | Aging in rodents and primates is accompanied by changes in hypothalamic-pituitary-adrenal (HPA) activity. We examined behavioral and neuroendocrine responses in 3, 15-, and 30-month-old F344/Brown-Norway rats. Basal corticosterone and ACTH levels did not differ with age, although ACTH responses, but not corticosterone responses to restraint stress, were significantly lower in the 30-month-old group relative to 3- and 15-month-old rats. Induction of c-fos mRNA in the paraventricular nucleus from restraint was not affected by age. Furthermore, there was an enhanced sensitivity to dexamethasone suppression in aged animals as evidenced by lesser ACTH and corticosterone release after dexamethasone administration. Evaluation of emotional behaviors in the forced swim test revealed no differences between the age groups. With fear conditioning, aged rats had decreased freeze times relative to middle-aged or young rats. Regression analysis revealed no significant correlations between the behavioral and HPA axis data in any group. Overall, the data suggest that an apparent decrease in pituitary drive is compensated for at the level of the adrenal, resulting in stable patterns of glucocorticoid secretion. The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model. |
| doi_str_mv | 10.1210/en.2004-1648 |
| format | Article |
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We examined behavioral and neuroendocrine responses in 3, 15-, and 30-month-old F344/Brown-Norway rats. Basal corticosterone and ACTH levels did not differ with age, although ACTH responses, but not corticosterone responses to restraint stress, were significantly lower in the 30-month-old group relative to 3- and 15-month-old rats. Induction of c-fos mRNA in the paraventricular nucleus from restraint was not affected by age. Furthermore, there was an enhanced sensitivity to dexamethasone suppression in aged animals as evidenced by lesser ACTH and corticosterone release after dexamethasone administration. Evaluation of emotional behaviors in the forced swim test revealed no differences between the age groups. With fear conditioning, aged rats had decreased freeze times relative to middle-aged or young rats. Regression analysis revealed no significant correlations between the behavioral and HPA axis data in any group. Overall, the data suggest that an apparent decrease in pituitary drive is compensated for at the level of the adrenal, resulting in stable patterns of glucocorticoid secretion. The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2004-1648</identifier><identifier>PMID: 15831572</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adrenocorticotropic hormone ; Adrenocorticotropic Hormone - secretion ; Age ; Aging ; Aging - metabolism ; Aging - psychology ; Animals ; Behavior ; Behavior, Animal ; Biological and medical sciences ; c-Fos protein ; Conditioning ; Conditioning (Psychology) ; Constraints ; Corticosterone ; Corticosterone - secretion ; Dexamethasone ; Dexamethasone - pharmacology ; Emotional behavior ; Fear ; Fear conditioning ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids ; Glucocorticoids - pharmacology ; Hybridization, Genetic ; Hypothalamic-pituitary-adrenal axis ; Hypothalamus ; Male ; Models, Animal ; mRNA ; Neuroendocrine system ; Neurosecretory Systems - metabolism ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular nucleus ; Pituitary ; Proto-Oncogene Proteins c-fos - genetics ; Rats ; Rats, Inbred BN ; Rats, Inbred F344 ; Regression Analysis ; Restraint, Physical ; RNA, Messenger - metabolism ; Sensitivity analysis ; Stress, Physiological - etiology ; Stress, Physiological - metabolism ; Swimming ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2005-07, Vol.146 (7), p.3105-3112</ispartof><rights>Copyright © 2005 by The Endocrine Society 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright © 2005 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-5ed7762255913a4b79dfa73b88f6404f6ef539dcc226a867604260a053c5c30b3</citedby><cites>FETCH-LOGICAL-c558t-5ed7762255913a4b79dfa73b88f6404f6ef539dcc226a867604260a053c5c30b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16878168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15831572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasckow, John W</creatorcontrib><creatorcontrib>Segar, Tracy M</creatorcontrib><creatorcontrib>Xiao, Chun</creatorcontrib><creatorcontrib>Furay, Amy R</creatorcontrib><creatorcontrib>Evanson, Nathan K</creatorcontrib><creatorcontrib>Ostrander, Michelle M</creatorcontrib><creatorcontrib>Herman, James P</creatorcontrib><title>Stability of Neuroendocrine and Behavioral Responsiveness in Aging Fischer 344/Brown-Norway Hybrid Rats</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Aging in rodents and primates is accompanied by changes in hypothalamic-pituitary-adrenal (HPA) activity. We examined behavioral and neuroendocrine responses in 3, 15-, and 30-month-old F344/Brown-Norway rats. Basal corticosterone and ACTH levels did not differ with age, although ACTH responses, but not corticosterone responses to restraint stress, were significantly lower in the 30-month-old group relative to 3- and 15-month-old rats. Induction of c-fos mRNA in the paraventricular nucleus from restraint was not affected by age. Furthermore, there was an enhanced sensitivity to dexamethasone suppression in aged animals as evidenced by lesser ACTH and corticosterone release after dexamethasone administration. Evaluation of emotional behaviors in the forced swim test revealed no differences between the age groups. With fear conditioning, aged rats had decreased freeze times relative to middle-aged or young rats. Regression analysis revealed no significant correlations between the behavioral and HPA axis data in any group. Overall, the data suggest that an apparent decrease in pituitary drive is compensated for at the level of the adrenal, resulting in stable patterns of glucocorticoid secretion. The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model.</description><subject>Adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - secretion</subject><subject>Age</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aging - psychology</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>c-Fos protein</subject><subject>Conditioning</subject><subject>Conditioning (Psychology)</subject><subject>Constraints</subject><subject>Corticosterone</subject><subject>Corticosterone - secretion</subject><subject>Dexamethasone</subject><subject>Dexamethasone - pharmacology</subject><subject>Emotional behavior</subject><subject>Fear</subject><subject>Fear conditioning</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - pharmacology</subject><subject>Hybridization, Genetic</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamus</subject><subject>Male</subject><subject>Models, Animal</subject><subject>mRNA</subject><subject>Neuroendocrine system</subject><subject>Neurosecretory Systems - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular nucleus</subject><subject>Pituitary</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Rats, Inbred F344</subject><subject>Regression Analysis</subject><subject>Restraint, Physical</subject><subject>RNA, Messenger - metabolism</subject><subject>Sensitivity analysis</subject><subject>Stress, Physiological - etiology</subject><subject>Stress, Physiological - metabolism</subject><subject>Swimming</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYB-Agil2rN88SEPXitPlO5tgWa4VSoep5yGTe2abMJmMy07L_vVl2cEEUL3kJPLwf_BB6TckJZZScQjhhhIiKKmGeoBWthaw01eQpWhFCeaUZ00foRc735SuE4M_REZWGU6nZCq2_Tbb1g5-2OPb4BuYUIXTRJR8A29Dhc7izDz4mO-BbyGMM2T9AgJyxD_hs7cMaX_rs7iBhLsTpeYqPobqJ6dFu8dW2Tb7Dt3bKL9Gz3g4ZXi31GP24_PT94qq6_vr5y8XZdeWkNFMlodNaMSZlTbkVra673mreGtMrQUSvoJe87pxjTFmjtCKCKWKJ5E46Tlp-jN7v-44p_pwhT82mbAfDYAPEOTdK11Sbcv7_INVcCSrqAt_-Ae_jnEI5ouGUE6lqwlRRH_fKpZhzgr4Zk9_YtG0oaXY5NRCaXU7NLqfC3yxN53YD3QEvwRTwbgE2Ozv0yQbn88Epo015ivuwd3Ee_zWyWkbyvfyd75hKjIdr_rroL0vKteE</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Kasckow, John W</creator><creator>Segar, Tracy M</creator><creator>Xiao, Chun</creator><creator>Furay, Amy R</creator><creator>Evanson, Nathan K</creator><creator>Ostrander, Michelle M</creator><creator>Herman, James P</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Stability of Neuroendocrine and Behavioral Responsiveness in Aging Fischer 344/Brown-Norway Hybrid Rats</title><author>Kasckow, John W ; Segar, Tracy M ; Xiao, Chun ; Furay, Amy R ; Evanson, Nathan K ; Ostrander, Michelle M ; Herman, James P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-5ed7762255913a4b79dfa73b88f6404f6ef539dcc226a867604260a053c5c30b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - secretion</topic><topic>Age</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Aging - psychology</topic><topic>Animals</topic><topic>Behavior</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>c-Fos protein</topic><topic>Conditioning</topic><topic>Conditioning (Psychology)</topic><topic>Constraints</topic><topic>Corticosterone</topic><topic>Corticosterone - secretion</topic><topic>Dexamethasone</topic><topic>Dexamethasone - pharmacology</topic><topic>Emotional behavior</topic><topic>Fear</topic><topic>Fear conditioning</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - pharmacology</topic><topic>Hybridization, Genetic</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamus</topic><topic>Male</topic><topic>Models, Animal</topic><topic>mRNA</topic><topic>Neuroendocrine system</topic><topic>Neurosecretory Systems - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular nucleus</topic><topic>Pituitary</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Rats, Inbred F344</topic><topic>Regression Analysis</topic><topic>Restraint, Physical</topic><topic>RNA, Messenger - metabolism</topic><topic>Sensitivity analysis</topic><topic>Stress, Physiological - etiology</topic><topic>Stress, Physiological - metabolism</topic><topic>Swimming</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasckow, John W</creatorcontrib><creatorcontrib>Segar, Tracy M</creatorcontrib><creatorcontrib>Xiao, Chun</creatorcontrib><creatorcontrib>Furay, Amy R</creatorcontrib><creatorcontrib>Evanson, Nathan K</creatorcontrib><creatorcontrib>Ostrander, Michelle M</creatorcontrib><creatorcontrib>Herman, James P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasckow, John W</au><au>Segar, Tracy M</au><au>Xiao, Chun</au><au>Furay, Amy R</au><au>Evanson, Nathan K</au><au>Ostrander, Michelle M</au><au>Herman, James P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability of Neuroendocrine and Behavioral Responsiveness in Aging Fischer 344/Brown-Norway Hybrid Rats</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>146</volume><issue>7</issue><spage>3105</spage><epage>3112</epage><pages>3105-3112</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Aging in rodents and primates is accompanied by changes in hypothalamic-pituitary-adrenal (HPA) activity. We examined behavioral and neuroendocrine responses in 3, 15-, and 30-month-old F344/Brown-Norway rats. Basal corticosterone and ACTH levels did not differ with age, although ACTH responses, but not corticosterone responses to restraint stress, were significantly lower in the 30-month-old group relative to 3- and 15-month-old rats. Induction of c-fos mRNA in the paraventricular nucleus from restraint was not affected by age. Furthermore, there was an enhanced sensitivity to dexamethasone suppression in aged animals as evidenced by lesser ACTH and corticosterone release after dexamethasone administration. Evaluation of emotional behaviors in the forced swim test revealed no differences between the age groups. With fear conditioning, aged rats had decreased freeze times relative to middle-aged or young rats. Regression analysis revealed no significant correlations between the behavioral and HPA axis data in any group. Overall, the data suggest that an apparent decrease in pituitary drive is compensated for at the level of the adrenal, resulting in stable patterns of glucocorticoid secretion. The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>15831572</pmid><doi>10.1210/en.2004-1648</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenocorticotropic hormone Adrenocorticotropic Hormone - secretion Age Aging Aging - metabolism Aging - psychology Animals Behavior Behavior, Animal Biological and medical sciences c-Fos protein Conditioning Conditioning (Psychology) Constraints Corticosterone Corticosterone - secretion Dexamethasone Dexamethasone - pharmacology Emotional behavior Fear Fear conditioning Fundamental and applied biological sciences. Psychology Glucocorticoids Glucocorticoids - pharmacology Hybridization, Genetic Hypothalamic-pituitary-adrenal axis Hypothalamus Male Models, Animal mRNA Neuroendocrine system Neurosecretory Systems - metabolism Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Pituitary Proto-Oncogene Proteins c-fos - genetics Rats Rats, Inbred BN Rats, Inbred F344 Regression Analysis Restraint, Physical RNA, Messenger - metabolism Sensitivity analysis Stress, Physiological - etiology Stress, Physiological - metabolism Swimming Vertebrates: endocrinology |
| title | Stability of Neuroendocrine and Behavioral Responsiveness in Aging Fischer 344/Brown-Norway Hybrid Rats |
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