Identification of germ cells at risk for neoplastic transformation in gonadoblastoma An immunohistochemical study for OCT3/4 and TSPY

Carcinoma in situ (CIS) is the precursor of malignant testicular germ cell tumors (GCTs) of adolescents and young adults, being the neoplastic counterpart of primordial germ cells/gonocytes. Carcinoma in situ cells will develop into invasive seminoma/nonseminoma. Gonadoblastoma (GB) is the precursor...

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Veröffentlicht in:	Human pathology 2005-05, Vol.36 (5), p.512-521
Hauptverfasser:	KERSEMAEKERS, Anne-Marie F, HONECKER, Friedemann, LOOIJENGA, Leendert H. J, STOOP, Hans, COOLS, Martine, MOLIER, Michel, WOLFFENBUTTEL, Katja, BOKEMEYER, Carsten, YUNMIN LI, LAU, Yun-Fai Chris, OOSTERHUIS, J. Wolter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alkaline Phosphatase Biological and medical sciences Biomarkers, Tumor - analysis Cell Cycle Proteins Cell Transformation, Neoplastic - pathology Chromosomes DNA-Binding Proteins - metabolism Dysgerminoma - metabolism Dysgerminoma - pathology Female Female genital diseases Females Genetics Germ Cells - pathology Gonadoblastoma - metabolism Gonadoblastoma - pathology GPI-Linked Proteins Gynecology. Andrology. Obstetrics Histology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Isoenzymes - metabolism Male Medical sciences Nuclear Proteins - metabolism Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pathogenesis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-kit - metabolism Seminoma - metabolism Seminoma - pathology Sex-Determining Region Y Protein Studies Testicular Neoplasms - metabolism Testicular Neoplasms - pathology Transcription Factors - metabolism Tumors
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