Adaptor usage and Toll-like receptor signaling specificity
It is now well established that Toll-like receptors (TLRs) act as primary sensors of microbial compounds. Details of the molecular mechanisms governing TLR responses are emerging steadily and our understanding of the signaling pathways activated these receptors has improved greatly over the last few...
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| Veröffentlicht in: | FEBS letters 2005-06, Vol.579 (15), p.3330-3335 |
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| container_title | FEBS letters |
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| creator | Dunne, Aisling O’Neill, Luke A.J. |
| description | It is now well established that Toll-like receptors (TLRs) act as primary sensors of microbial compounds. Details of the molecular mechanisms governing TLR responses are emerging steadily and our understanding of the signaling pathways activated these receptors has improved greatly over the last few years. Differences in adaptor usage, cellular localisation and signaling cascades have been elucidated. In this review we will summarize the current understanding of TLR signaling and its regulation. |
| doi_str_mv | 10.1016/j.febslet.2005.04.024 |
| format | Article |
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| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2005-06, Vol.579 (15), p.3330-3335 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Wiley Journals; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Adaptor Proteins, Signal Transducing - metabolism Adaptors Animals Cell Membrane - metabolism Gene Expression Regulation Humans Innate immunity Membrane Glycoproteins - classification Membrane Glycoproteins - metabolism Receptors, Cell Surface - classification Receptors, Cell Surface - metabolism Signal Transduction Substrate Specificity Toll-Like Receptors |
| title | Adaptor usage and Toll-like receptor signaling specificity |
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