Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study)

OBJECTIVE: To investigate associations of body composition assessed by bioimpedance analysis and anthropometric indicators of fat repartition with carotid structure and function. DESIGN: Cross-sectional epidemiological study. SUBJECTS: A total of 1014 middle-aged apparently healthy adults participat...

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Veröffentlicht in:International Journal of Obesity 2005-07, Vol.29 (7), p.826-832
Hauptverfasser: Czernichow, S, Bertrais, S, Oppert, J-M, Galan, P, Blacher, J, Ducimetière, P, Hercberg, S, Zureik, M
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container_end_page 832
container_issue 7
container_start_page 826
container_title International Journal of Obesity
container_volume 29
creator Czernichow, S
Bertrais, S
Oppert, J-M
Galan, P
Blacher, J
Ducimetière, P
Hercberg, S
Zureik, M
description OBJECTIVE: To investigate associations of body composition assessed by bioimpedance analysis and anthropometric indicators of fat repartition with carotid structure and function. DESIGN: Cross-sectional epidemiological study. SUBJECTS: A total of 1014 middle-aged apparently healthy adults participating in the SU.VI.MAX study. MEASUREMENTS: Body composition (fat mass, fat-free mass) was assessed by bioimpedance analysis and anthropometric indicators of fat repartition (waist circumference (WC); waist-hip-ratio (WHR)) were simultaneously collected. Carotid ultrasound examination included measurements of intima-media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in extracranial carotid arteries. Carotid-femoral pulse-wave velocity (PWV) was used as a marker of aortic stiffness. RESULTS: In multivariate analyses adjusted for major known cardiovascular risk factors in addition to age, gender and height, fat-free mass, fat mass (FM), and WC were positively associated with CCA-IMT and lumen diameter. No significant association was found with occurrence of carotid plaques. PWV was only associated with WC. Associations of CCA-IMT and PWV with WC were not significant anymore after further adjustment on body mass index (BMI) or FM. CONCLUSION: WC was the only measurement positively associated with both early atherosclerosis markers such as CCA-IMT and arterial stiffness. Although this association depends on overall adiposity, as assessed by the BMI, it emphasizes the importance of WC in clinical practice and prevention programs as a screening tool for individuals at risk for cardiovascular disease.
doi_str_mv 10.1038/sj.ijo.0802986
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DESIGN: Cross-sectional epidemiological study. SUBJECTS: A total of 1014 middle-aged apparently healthy adults participating in the SU.VI.MAX study. MEASUREMENTS: Body composition (fat mass, fat-free mass) was assessed by bioimpedance analysis and anthropometric indicators of fat repartition (waist circumference (WC); waist-hip-ratio (WHR)) were simultaneously collected. Carotid ultrasound examination included measurements of intima-media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in extracranial carotid arteries. Carotid-femoral pulse-wave velocity (PWV) was used as a marker of aortic stiffness. RESULTS: In multivariate analyses adjusted for major known cardiovascular risk factors in addition to age, gender and height, fat-free mass, fat mass (FM), and WC were positively associated with CCA-IMT and lumen diameter. No significant association was found with occurrence of carotid plaques. PWV was only associated with WC. 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subjects Abdomen
Adipose Tissue - pathology
Anthropometry
Arteriosclerosis - diagnostic imaging
Arteriosclerosis - pathology
Arteriosclerosis - physiopathology
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Body Composition
Body fat
Body mass index
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular diseases
Carotid arteries
Carotid Artery, Common - diagnostic imaging
Carotid Artery, Common - pathology
Electric Impedance
Epidemiology
Female
Health Promotion and Disease Prevention
Health risks
Humans
Internal Medicine
Logistic Models
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle age
Middle Aged
Multivariate Analysis
Obesity
Obesity - diagnostic imaging
Obesity - pathology
Obesity - physiopathology
Prevention
Public Health
Risk Factors
Ultrasonography
Veins & arteries
Wave velocity
title Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study)
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