Gene Expression Profile in Oral Squamous Cell Carcinoma: A Pilot Study
To study the gene expression profile of oral squamous cell carcinomas. Gene expression profile was investigated in oral squamous cell carcinomas in 5 patients using the Atlas Glass Human 3.8 I Microarray (which detects cDNA obtained from cellular total RNA) (Clontech Laboratories, Palo Alto, CA). Da...
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 2005-06, Vol.63 (6), p.786-792 |
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| container_title | Journal of oral and maxillofacial surgery |
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| creator | Somoza-Martín, José Manuel García-García, Abel Barros-Angueira, Francisco Otero-Rey, Eva Torres-Español, María Gándara-Vila, Pilar Reboiras-López, María Dolores Blanco-Carrión, Andrés Gándara-Rey, José Manuel |
| description | To study the gene expression profile of oral squamous cell carcinomas.
Gene expression profile was investigated in oral squamous cell carcinomas in 5 patients using the Atlas Glass Human 3.8 I Microarray (which detects cDNA obtained from cellular total RNA) (Clontech Laboratories, Palo Alto, CA). Data were normalized by the LOWESS method. Statistical significances of deviations from a 1:1 ratio were evaluated by t tests, with
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| doi_str_mv | 10.1016/j.joms.2005.02.014 |
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Gene expression profile was investigated in oral squamous cell carcinomas in 5 patients using the Atlas Glass Human 3.8 I Microarray (which detects cDNA obtained from cellular total RNA) (Clontech Laboratories, Palo Alto, CA). Data were normalized by the LOWESS method. Statistical significances of deviations from a 1:1 ratio were evaluated by t tests, with
P <.05.
Of the 3,757 genes analyzed, 322 (8.6%) were significantly overexpressed in tumoral tissue with respect to normal tissue, while 104 (2.8%) were significantly underexpressed. The affected genes fell into a wide range of functional categories.
We consider that cDNA microarrays are of clear value for investigating the biology of these tumors, and that this technology may help in the molecular classification of oral squamous cell carcinomas and in the identification of targets for gene therapy.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/j.joms.2005.02.014</identifier><identifier>PMID: 15944975</identifier><identifier>CODEN: JOMSDA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Dentistry ; DNA, Neoplasm - analysis ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mandibular Neoplasms - genetics ; Mandibular Neoplasms - pathology ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Otorhinolaryngology. Stomatology ; Pilot Projects ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of oral and maxillofacial surgery, 2005-06, Vol.63 (6), p.786-792</ispartof><rights>2005 American Association of Oral and Maxillofacial Surgeons</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-a40f3807f3753f7fe6e5607db8e13f33da338d6cd7179a28ca725da0c8b10a4a3</citedby><cites>FETCH-LOGICAL-c384t-a40f3807f3753f7fe6e5607db8e13f33da338d6cd7179a28ca725da0c8b10a4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joms.2005.02.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16873719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15944975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Somoza-Martín, José Manuel</creatorcontrib><creatorcontrib>García-García, Abel</creatorcontrib><creatorcontrib>Barros-Angueira, Francisco</creatorcontrib><creatorcontrib>Otero-Rey, Eva</creatorcontrib><creatorcontrib>Torres-Español, María</creatorcontrib><creatorcontrib>Gándara-Vila, Pilar</creatorcontrib><creatorcontrib>Reboiras-López, María Dolores</creatorcontrib><creatorcontrib>Blanco-Carrión, Andrés</creatorcontrib><creatorcontrib>Gándara-Rey, José Manuel</creatorcontrib><title>Gene Expression Profile in Oral Squamous Cell Carcinoma: A Pilot Study</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>To study the gene expression profile of oral squamous cell carcinomas.
Gene expression profile was investigated in oral squamous cell carcinomas in 5 patients using the Atlas Glass Human 3.8 I Microarray (which detects cDNA obtained from cellular total RNA) (Clontech Laboratories, Palo Alto, CA). Data were normalized by the LOWESS method. Statistical significances of deviations from a 1:1 ratio were evaluated by t tests, with
P <.05.
Of the 3,757 genes analyzed, 322 (8.6%) were significantly overexpressed in tumoral tissue with respect to normal tissue, while 104 (2.8%) were significantly underexpressed. The affected genes fell into a wide range of functional categories.
We consider that cDNA microarrays are of clear value for investigating the biology of these tumors, and that this technology may help in the molecular classification of oral squamous cell carcinomas and in the identification of targets for gene therapy.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Dentistry</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>Mandibular Neoplasms - genetics</subject><subject>Mandibular Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pilot Projects</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAURUVpaSZp_0AXRZt2Z_dJsiy5dDMM-YJAAmnXQiM9gQbbmkh2SP59PcxAdlndzbmXyyHkG4OaAWt_7epdGkrNAWQNvAbWfCArJgWrJEjxkayAK11x0bEzcl7KDoAxqdrP5IzJrmk6JVfk6hpHpJcv-4ylxDTSh5xC7JHGkd5n29PHp9kOaS50g31PNza7OKbB_qZr-hD7NNHHafavX8inYPuCX095Qf5dXf7d3FR399e3m_Vd5YRupso2EIQGFYSSIqiALcoWlN9qZCII4a0Q2rfOK6Y6y7WziktvwektA9tYcUF-Hnf3OT3NWCYzxOKWZ3bE5aRpVcdapvkC8iPociolYzD7HAebXw0Dc7BnduZgzxzsGeBmsbeUvp_W5-2A_q1y0rUAP06ALc72IdvRxfLGtVoJxbqF-3PkcHHxHDGb4iKODn3M6CbjU3zvx39r9IyI</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Somoza-Martín, José Manuel</creator><creator>García-García, Abel</creator><creator>Barros-Angueira, Francisco</creator><creator>Otero-Rey, Eva</creator><creator>Torres-Español, María</creator><creator>Gándara-Vila, Pilar</creator><creator>Reboiras-López, María Dolores</creator><creator>Blanco-Carrión, Andrés</creator><creator>Gándara-Rey, José Manuel</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20050601</creationdate><title>Gene Expression Profile in Oral Squamous Cell Carcinoma: A Pilot Study</title><author>Somoza-Martín, José Manuel ; García-García, Abel ; Barros-Angueira, Francisco ; Otero-Rey, Eva ; Torres-Español, María ; Gándara-Vila, Pilar ; Reboiras-López, María Dolores ; Blanco-Carrión, Andrés ; Gándara-Rey, José Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-a40f3807f3753f7fe6e5607db8e13f33da338d6cd7179a28ca725da0c8b10a4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Dentistry</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>Mandibular Neoplasms - genetics</topic><topic>Mandibular Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pilot Projects</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Somoza-Martín, José Manuel</creatorcontrib><creatorcontrib>García-García, Abel</creatorcontrib><creatorcontrib>Barros-Angueira, Francisco</creatorcontrib><creatorcontrib>Otero-Rey, Eva</creatorcontrib><creatorcontrib>Torres-Español, María</creatorcontrib><creatorcontrib>Gándara-Vila, Pilar</creatorcontrib><creatorcontrib>Reboiras-López, María Dolores</creatorcontrib><creatorcontrib>Blanco-Carrión, Andrés</creatorcontrib><creatorcontrib>Gándara-Rey, José Manuel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Somoza-Martín, José Manuel</au><au>García-García, Abel</au><au>Barros-Angueira, Francisco</au><au>Otero-Rey, Eva</au><au>Torres-Español, María</au><au>Gándara-Vila, Pilar</au><au>Reboiras-López, María Dolores</au><au>Blanco-Carrión, Andrés</au><au>Gándara-Rey, José Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene Expression Profile in Oral Squamous Cell Carcinoma: A Pilot Study</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>63</volume><issue>6</issue><spage>786</spage><epage>792</epage><pages>786-792</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><coden>JOMSDA</coden><abstract>To study the gene expression profile of oral squamous cell carcinomas.
Gene expression profile was investigated in oral squamous cell carcinomas in 5 patients using the Atlas Glass Human 3.8 I Microarray (which detects cDNA obtained from cellular total RNA) (Clontech Laboratories, Palo Alto, CA). Data were normalized by the LOWESS method. Statistical significances of deviations from a 1:1 ratio were evaluated by t tests, with
P <.05.
Of the 3,757 genes analyzed, 322 (8.6%) were significantly overexpressed in tumoral tissue with respect to normal tissue, while 104 (2.8%) were significantly underexpressed. The affected genes fell into a wide range of functional categories.
We consider that cDNA microarrays are of clear value for investigating the biology of these tumors, and that this technology may help in the molecular classification of oral squamous cell carcinomas and in the identification of targets for gene therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15944975</pmid><doi>10.1016/j.joms.2005.02.014</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Dentistry DNA, Neoplasm - analysis Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Male Mandibular Neoplasms - genetics Mandibular Neoplasms - pathology Medical sciences Middle Aged Neoplasm Staging Oligonucleotide Array Sequence Analysis Otorhinolaryngology. Stomatology Pilot Projects Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Gene Expression Profile in Oral Squamous Cell Carcinoma: A Pilot Study |
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