Activation of CD8+ Regulatory T Cells by Human Placental Trophoblasts

The immunological basis by which a mother tolerates her semi-allogeneic fetus remains poorly understood. Several mechanisms are likely to contribute to this phenomenon including active immune regulation by regulatory T cells. In this article, we report that human placental trophoblasts activate a cl...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-06, Vol.174 (12), p.7539-7547
Hauptverfasser:	Shao, Ling, Jacobs, Adam R, Johnson, Valrie V, Mayer, Lloyd
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD1 - biosynthesis Antigens, CD1d Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - immunology Cell Differentiation - immunology Cells, Cultured Coculture Techniques Cytokines - biosynthesis Cytotoxicity, Immunologic Female Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Humans Immunophenotyping Integrin alpha Chains - biosynthesis Lymphocyte Activation - immunology Membrane Glycoproteins - biosynthesis Placenta - cytology Placenta - immunology Placenta - metabolism Pregnancy Trophoblasts - immunology Trophoblasts - metabolism
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