Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3

Glycyrrhizae Radix is used to treat abdominal pain as a component of Shakuyaku-kanzo-to, a traditional Chinese medicine formulation. We aim at clarifying the antispasmodic principles of Glycyrrhizae Radix, and consequently isolated glycycoumarin as a potent relaxant on the carbamylcholine (CCh)-indu...

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Veröffentlicht in:	Journal of ethnopharmacology 2006-05, Vol.105 (3), p.409-414
Hauptverfasser:	Sato, Yuji, Akao, Teruaki, He, Ju-Xiu, Nojima, Hiroshi, Kuraishi, Yasushi, Morota, Takashi, Asano, Takayuki, Tani, Tadato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antispasmodic Biological and medical sciences cAMP Carbachol - pharmacology Coumarins - isolation & purification Coumarins - pharmacology Cyclic AMP - analysis Cyclic GMP - analysis Dose-Response Relationship, Drug General pharmacology Glycycoumarin Glycyrrhiza ularensis Glycyrrhiza uralensis - chemistry Glycyrrhizae Radix Jejunum - drug effects Jejunum - physiology Leguminosae Male Medical sciences Mice Mice, Inbred ICR Muscle Contraction - drug effects Parasympatholytics - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphodiesterase Phosphodiesterase Inhibitors - pharmacology
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