Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema

Th1/Tc1 inflammation and remodeling responses characterized by tissue atrophy and destruction frequently coexist in human diseases and disorders. However, the mechanisms that are used by Th1/Tc1 cytokines, like IFN-gamma, to induce these responses have not been defined. To elucidate the mechanism(s)...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-06, Vol.174 (12), p.8106-8115
Hauptverfasser:	Zheng, Tao, Kang, Min Jong, Crothers, Kristina, Zhu, Zhou, Liu, Wei, Lee, Chun Geun, Rabach, Lesley A, Chapman, Harold A, Homer, Robert J, Aldous, David, De Sanctis, George T, Desanctis, George, Underwood, Stephen, Graupe, Michael, Flavell, Richard A, Schmidt, John A, Elias, Jack A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis - immunology Cathepsins - biosynthesis Cathepsins - deficiency Cathepsins - genetics Cathepsins - physiology Disease Models, Animal DNA Damage - immunology Enzyme Induction - genetics Enzyme Induction - immunology Humans Inflammation - enzymology Inflammation - immunology Inflammation - pathology Interferon-gamma - physiology Lung - enzymology Lung - immunology Lung - pathology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Organ Specificity - genetics Organ Specificity - immunology Pulmonary Alveoli - enzymology Pulmonary Alveoli - immunology Pulmonary Alveoli - pathology Pulmonary Emphysema - enzymology Pulmonary Emphysema - genetics Pulmonary Emphysema - immunology Pulmonary Emphysema - pathology Respiratory Mucosa - cytology Respiratory Mucosa - enzymology Respiratory Mucosa - immunology Signal Transduction - genetics Signal Transduction - immunology
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