Functional Reconstitution of Protein Ion Channels into Planar Polymerizable Phospholipid Membranes

We demonstrate that polymerizable planar membranes permit reconstitution of protein ion channels formed by the bacterial toxins Staphylococcus aureus α-hemolysin (αHL) and Bacillus anthracis protective antigen 63. The αHL channel remained functional even after membrane polymerization. Surface pressu...

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Veröffentlicht in:	Nano letters 2005-06, Vol.5 (6), p.1181-1185
Hauptverfasser:	Shenoy, Devanand K, Barger, William R, Singh, Alok, Panchal, Rekha G, Misakian, Martin, Stanford, Vincent M, Kasianowicz, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - chemistry Applied sciences Bacillus anthracis - metabolism Bacterial Toxins - chemistry Cell Membrane - metabolism Cell Membrane Permeability Condensed matter: structure, mechanical and thermal properties Electronics Escherichia coli Proteins - chemistry Exact sciences and technology Hemolysin Proteins - chemistry Ion Channels - chemistry Ions Lipid Bilayers Lipids - chemistry Membrane Lipids - chemistry Microelectronic fabrication (materials and surfaces technology) Models, Chemical Nanoscale materials: clusters, nanoparticles, nanotubes, and nanocrystals Nanotechnology Phospholipids - chemistry Physics Polymers - chemistry Pressure Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices Staphylococcus aureus - metabolism Structure of solids and liquids crystallography Surface Properties Time Factors
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