On the mechanisms of glycolytic oscillations in yeast
This work concerns the cause of glycolytic oscillations in yeast. We analyse experimental data as well as models in two distinct cases: the relaxation‐like oscillations seen in yeast extracts, and the sinusoidal Hopf oscillations seen in intact yeast cells. In the case of yeast extracts, we use flux...
Gespeichert in:
| Veröffentlicht in: | The FEBS journal 2005-06, Vol.272 (11), p.2648-2660 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2660 |
|---|---|
| container_issue | 11 |
| container_start_page | 2648 |
| container_title | The FEBS journal |
| container_volume | 272 |
| creator | Madsen, Mads F. Danø, Sune Sørensen, Preben G |
| description | This work concerns the cause of glycolytic oscillations in yeast. We analyse experimental data as well as models in two distinct cases: the relaxation‐like oscillations seen in yeast extracts, and the sinusoidal Hopf oscillations seen in intact yeast cells. In the case of yeast extracts, we use flux‐change plots and model analyses to establish that the oscillations are driven by on/off switching of phosphofructokinase. In the case of intact yeast cells, we find that the instability leading to the appearance of oscillations is caused by the stoichiometry of the ATP‐ADP‐AMP system and the allosteric regulation of phosphofructokinase, whereas frequency control is distributed over the reaction network. Notably, the NAD+/NADH ratio modulates the frequency of the oscillations without affecting the instability. This is important for understanding the mutual synchronization of oscillations in the individual yeast cells, as synchronization is believed to occur via acetaldehyde, which in turn affects the frequency of oscillations by changing this ratio. |
| doi_str_mv | 10.1111/j.1742-4658.2005.04639.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67915402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17538961</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5429-e37e60799c02a99f14965fa4622ee1bbbdc4e2db0b49b793f8b4b4b5f5dedbfe3</originalsourceid><addsrcrecordid>eNqNkV9LwzAUxYMobk6_ggQffGtN0qRtXgQdmwqDPajgW2jSW9fRP7Npcf32pm5M8EVzH3Lh_u4hOQchTIlP3blZ-zTizOOhiH1GiPAJDwPpb4_Q-DA4PvT8bYTOrF0TEggu5SkaUSF5EBMyRmJZ4XYFuASzSqrclhbXGX4velMXfZsbXFuTF0XS5nVlcV7hHhLbnqOTLCksXOzvCXqdz16mj95i-fA0vVt4RnAmPQgiCEkkpSEskTKjXIYiS3jIGADVWqeGA0s10VzqSAZZrLkrkYkUUp1BMEHXO91NU390YFtV5taAe08FdWdVGEkqOGF_gjQSQSxD6sCrX-C67prKfUIxwqkzJgodFO8g09TWNpCpTZOXSdMrStQQgFqrwVs1-KyGANR3AGrrVi_3-p0uIf1Z3DvugNsd8JkX0P9bWM1n989DG3wB_5KT4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204115976</pqid></control><display><type>article</type><title>On the mechanisms of glycolytic oscillations in yeast</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Free Full-Text Journals in Chemistry</source><creator>Madsen, Mads F. ; Danø, Sune ; Sørensen, Preben G</creator><creatorcontrib>Madsen, Mads F. ; Danø, Sune ; Sørensen, Preben G</creatorcontrib><description>This work concerns the cause of glycolytic oscillations in yeast. We analyse experimental data as well as models in two distinct cases: the relaxation‐like oscillations seen in yeast extracts, and the sinusoidal Hopf oscillations seen in intact yeast cells. In the case of yeast extracts, we use flux‐change plots and model analyses to establish that the oscillations are driven by on/off switching of phosphofructokinase. In the case of intact yeast cells, we find that the instability leading to the appearance of oscillations is caused by the stoichiometry of the ATP‐ADP‐AMP system and the allosteric regulation of phosphofructokinase, whereas frequency control is distributed over the reaction network. Notably, the NAD+/NADH ratio modulates the frequency of the oscillations without affecting the instability. This is important for understanding the mutual synchronization of oscillations in the individual yeast cells, as synchronization is believed to occur via acetaldehyde, which in turn affects the frequency of oscillations by changing this ratio.</description><identifier>ISSN: 1742-464X</identifier><identifier>EISSN: 1742-4658</identifier><identifier>DOI: 10.1111/j.1742-4658.2005.04639.x</identifier><identifier>PMID: 15943800</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adenosine Triphosphate - metabolism ; Biochemistry ; Glycolysis ; Glycosylation ; Hopf bifurcation ; Kinetics ; metabolic control analysis ; Models, Biological ; NAD - metabolism ; oscillations ; oscillophore ; Peptides ; Phosphofructokinases - physiology ; Saccharomyces cerevisiae - physiology ; Signal transduction ; Yeast</subject><ispartof>The FEBS journal, 2005-06, Vol.272 (11), p.2648-2660</ispartof><rights>Copyright Blackwell Publishing Jun 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5429-e37e60799c02a99f14965fa4622ee1bbbdc4e2db0b49b793f8b4b4b5f5dedbfe3</citedby><cites>FETCH-LOGICAL-c5429-e37e60799c02a99f14965fa4622ee1bbbdc4e2db0b49b793f8b4b4b5f5dedbfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1742-4658.2005.04639.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1742-4658.2005.04639.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27931,27932,45581,45582,46416,46840</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15943800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madsen, Mads F.</creatorcontrib><creatorcontrib>Danø, Sune</creatorcontrib><creatorcontrib>Sørensen, Preben G</creatorcontrib><title>On the mechanisms of glycolytic oscillations in yeast</title><title>The FEBS journal</title><addtitle>FEBS J</addtitle><description>This work concerns the cause of glycolytic oscillations in yeast. We analyse experimental data as well as models in two distinct cases: the relaxation‐like oscillations seen in yeast extracts, and the sinusoidal Hopf oscillations seen in intact yeast cells. In the case of yeast extracts, we use flux‐change plots and model analyses to establish that the oscillations are driven by on/off switching of phosphofructokinase. In the case of intact yeast cells, we find that the instability leading to the appearance of oscillations is caused by the stoichiometry of the ATP‐ADP‐AMP system and the allosteric regulation of phosphofructokinase, whereas frequency control is distributed over the reaction network. Notably, the NAD+/NADH ratio modulates the frequency of the oscillations without affecting the instability. This is important for understanding the mutual synchronization of oscillations in the individual yeast cells, as synchronization is believed to occur via acetaldehyde, which in turn affects the frequency of oscillations by changing this ratio.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Biochemistry</subject><subject>Glycolysis</subject><subject>Glycosylation</subject><subject>Hopf bifurcation</subject><subject>Kinetics</subject><subject>metabolic control analysis</subject><subject>Models, Biological</subject><subject>NAD - metabolism</subject><subject>oscillations</subject><subject>oscillophore</subject><subject>Peptides</subject><subject>Phosphofructokinases - physiology</subject><subject>Saccharomyces cerevisiae - physiology</subject><subject>Signal transduction</subject><subject>Yeast</subject><issn>1742-464X</issn><issn>1742-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9LwzAUxYMobk6_ggQffGtN0qRtXgQdmwqDPajgW2jSW9fRP7Npcf32pm5M8EVzH3Lh_u4hOQchTIlP3blZ-zTizOOhiH1GiPAJDwPpb4_Q-DA4PvT8bYTOrF0TEggu5SkaUSF5EBMyRmJZ4XYFuASzSqrclhbXGX4velMXfZsbXFuTF0XS5nVlcV7hHhLbnqOTLCksXOzvCXqdz16mj95i-fA0vVt4RnAmPQgiCEkkpSEskTKjXIYiS3jIGADVWqeGA0s10VzqSAZZrLkrkYkUUp1BMEHXO91NU390YFtV5taAe08FdWdVGEkqOGF_gjQSQSxD6sCrX-C67prKfUIxwqkzJgodFO8g09TWNpCpTZOXSdMrStQQgFqrwVs1-KyGANR3AGrrVi_3-p0uIf1Z3DvugNsd8JkX0P9bWM1n989DG3wB_5KT4w</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Madsen, Mads F.</creator><creator>Danø, Sune</creator><creator>Sørensen, Preben G</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>On the mechanisms of glycolytic oscillations in yeast</title><author>Madsen, Mads F. ; Danø, Sune ; Sørensen, Preben G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5429-e37e60799c02a99f14965fa4622ee1bbbdc4e2db0b49b793f8b4b4b5f5dedbfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Biochemistry</topic><topic>Glycolysis</topic><topic>Glycosylation</topic><topic>Hopf bifurcation</topic><topic>Kinetics</topic><topic>metabolic control analysis</topic><topic>Models, Biological</topic><topic>NAD - metabolism</topic><topic>oscillations</topic><topic>oscillophore</topic><topic>Peptides</topic><topic>Phosphofructokinases - physiology</topic><topic>Saccharomyces cerevisiae - physiology</topic><topic>Signal transduction</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madsen, Mads F.</creatorcontrib><creatorcontrib>Danø, Sune</creatorcontrib><creatorcontrib>Sørensen, Preben G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The FEBS journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madsen, Mads F.</au><au>Danø, Sune</au><au>Sørensen, Preben G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the mechanisms of glycolytic oscillations in yeast</atitle><jtitle>The FEBS journal</jtitle><addtitle>FEBS J</addtitle><date>2005-06</date><risdate>2005</risdate><volume>272</volume><issue>11</issue><spage>2648</spage><epage>2660</epage><pages>2648-2660</pages><issn>1742-464X</issn><eissn>1742-4658</eissn><abstract>This work concerns the cause of glycolytic oscillations in yeast. We analyse experimental data as well as models in two distinct cases: the relaxation‐like oscillations seen in yeast extracts, and the sinusoidal Hopf oscillations seen in intact yeast cells. In the case of yeast extracts, we use flux‐change plots and model analyses to establish that the oscillations are driven by on/off switching of phosphofructokinase. In the case of intact yeast cells, we find that the instability leading to the appearance of oscillations is caused by the stoichiometry of the ATP‐ADP‐AMP system and the allosteric regulation of phosphofructokinase, whereas frequency control is distributed over the reaction network. Notably, the NAD+/NADH ratio modulates the frequency of the oscillations without affecting the instability. This is important for understanding the mutual synchronization of oscillations in the individual yeast cells, as synchronization is believed to occur via acetaldehyde, which in turn affects the frequency of oscillations by changing this ratio.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15943800</pmid><doi>10.1111/j.1742-4658.2005.04639.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-464X |
| ispartof | The FEBS journal, 2005-06, Vol.272 (11), p.2648-2660 |
| issn | 1742-464X 1742-4658 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67915402 |
| source | MEDLINE; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; Wiley Online Library (Open Access Collection); Free Full-Text Journals in Chemistry |
| subjects | Adenosine Triphosphate - metabolism Biochemistry Glycolysis Glycosylation Hopf bifurcation Kinetics metabolic control analysis Models, Biological NAD - metabolism oscillations oscillophore Peptides Phosphofructokinases - physiology Saccharomyces cerevisiae - physiology Signal transduction Yeast |
| title | On the mechanisms of glycolytic oscillations in yeast |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T09%3A04%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=On%20the%20mechanisms%20of%20glycolytic%20oscillations%20in%20yeast&rft.jtitle=The%20FEBS%20journal&rft.au=Madsen,%20Mads%20F.&rft.date=2005-06&rft.volume=272&rft.issue=11&rft.spage=2648&rft.epage=2660&rft.pages=2648-2660&rft.issn=1742-464X&rft.eissn=1742-4658&rft_id=info:doi/10.1111/j.1742-4658.2005.04639.x&rft_dat=%3Cproquest_cross%3E17538961%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204115976&rft_id=info:pmid/15943800&rfr_iscdi=true |