A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure
Summary Objective Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyro...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2005-06, Vol.62 (6), p.713-720 |
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| creator | Bülow Pedersen, Inge Laurberg, Peter Knudsen, Nils Jørgensen, Torben Perrild, Hans Ovesen, Lars Rasmussen, Lone Banke |
| description | Summary
Objective Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism.
Design A population study including 4649 randomly selected subjects.
Measurements Blood tests were used to analyse for thyroid peroxidase autoantibodies (TPO‐Ab), thyroglobulin autoantibodies (Tg‐Ab), TSH, fT3 and fT4.
Results Thyroid volume was categorized as small ( 14·9 ml) in 34·9% of participants. Thyroid nodules were found in 29·7%. Serum TSH was low ( 3·6) in 4·3%. The prevalence rate of subclinical goitrous Hashimoto's disease was 0·62% and of subclinical autoimmune atrophic thyroiditis 0·24%. There was a strong association between large volume and autoantibodies, but only in subjects with elevated TSH (P |
| doi_str_mv | 10.1111/j.1365-2265.2005.02284.x |
| format | Article |
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Objective Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism.
Design A population study including 4649 randomly selected subjects.
Measurements Blood tests were used to analyse for thyroid peroxidase autoantibodies (TPO‐Ab), thyroglobulin autoantibodies (Tg‐Ab), TSH, fT3 and fT4.
Results Thyroid volume was categorized as small (< 6·6 ml) in 4·7%, normal (6·6–14·9 ml) in 60·4% and large (> 14·9 ml) in 34·9% of participants. Thyroid nodules were found in 29·7%. Serum TSH was low (< 0·4 mIU/l) in 4·7%, normal (0·4–3·6) in 91·0% and high (> 3·6) in 4·3%. The prevalence rate of subclinical goitrous Hashimoto's disease was 0·62% and of subclinical autoimmune atrophic thyroiditis 0·24%. There was a strong association between large volume and autoantibodies, but only in subjects with elevated TSH (P < 0·001). An association between thyroid nodules and TPO‐Ab in univariate analyses (P < 0·001) was due to confounding by sex and age (multivariate model, P = 0·23).
Conclusion We identified a subgroup of the population with subclinical goitrous Hashimoto's disease and a smaller subgroup with subclinical autoimmune atrophic thyroiditis. This relationship between small and large thyroid volume in subclinical disease is opposite to that in overt disease, which may suggest that the period between development of a small volume with circulating autoantibodies and overt hypothyroidism is relatively short.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2005.02284.x</identifier><identifier>PMID: 15943834</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - blood ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Iodide Peroxidase - immunology ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Thyroglobulin - immunology ; Thyroid Gland - pathology ; Thyroid Gland - physiopathology ; Thyroiditis, Autoimmune - immunology ; Thyroiditis, Autoimmune - pathology ; Thyroiditis, Autoimmune - physiopathology ; Thyrotropin - blood ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2005-06, Vol.62 (6), p.713-720</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jun 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4624-2b3e595e6d8e0164eba28486fa4118c1994005f4a4332ec5a4c8cdbfa5c5df423</citedby><cites>FETCH-LOGICAL-c4624-2b3e595e6d8e0164eba28486fa4118c1994005f4a4332ec5a4c8cdbfa5c5df423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2005.02284.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2005.02284.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16815826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15943834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bülow Pedersen, Inge</creatorcontrib><creatorcontrib>Laurberg, Peter</creatorcontrib><creatorcontrib>Knudsen, Nils</creatorcontrib><creatorcontrib>Jørgensen, Torben</creatorcontrib><creatorcontrib>Perrild, Hans</creatorcontrib><creatorcontrib>Ovesen, Lars</creatorcontrib><creatorcontrib>Rasmussen, Lone Banke</creatorcontrib><title>A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism.
Design A population study including 4649 randomly selected subjects.
Measurements Blood tests were used to analyse for thyroid peroxidase autoantibodies (TPO‐Ab), thyroglobulin autoantibodies (Tg‐Ab), TSH, fT3 and fT4.
Results Thyroid volume was categorized as small (< 6·6 ml) in 4·7%, normal (6·6–14·9 ml) in 60·4% and large (> 14·9 ml) in 34·9% of participants. Thyroid nodules were found in 29·7%. Serum TSH was low (< 0·4 mIU/l) in 4·7%, normal (0·4–3·6) in 91·0% and high (> 3·6) in 4·3%. The prevalence rate of subclinical goitrous Hashimoto's disease was 0·62% and of subclinical autoimmune atrophic thyroiditis 0·24%. There was a strong association between large volume and autoantibodies, but only in subjects with elevated TSH (P < 0·001). An association between thyroid nodules and TPO‐Ab in univariate analyses (P < 0·001) was due to confounding by sex and age (multivariate model, P = 0·23).
Conclusion We identified a subgroup of the population with subclinical goitrous Hashimoto's disease and a smaller subgroup with subclinical autoimmune atrophic thyroiditis. This relationship between small and large thyroid volume in subclinical disease is opposite to that in overt disease, which may suggest that the period between development of a small volume with circulating autoantibodies and overt hypothyroidism is relatively short.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Iodide Peroxidase - immunology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyroiditis, Autoimmune - pathology</subject><subject>Thyroiditis, Autoimmune - physiopathology</subject><subject>Thyrotropin - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokPhL6AICXYJfo-zYFENbUEaDSzKY2c5jiM8JPHghzqz5J_jNKGVWOGNLZ_vXN17DwAFghXK5-2-QoSzEmPOKgwhqyDGglbHR2B1LzwGK0ggLCHn9Aw8C2EPMyng-ik4Q6ymRBC6Ar8vioM7pF5F68YixNSeCtcV8YcpVAhO21loTLw1Zsz_J-9sW6gUnRqjbVxrTShsthqfhkKNWWtG5wfV27hIf01dGvVdtYkK0ScdkzfPwZNO9cG8WO5z8OXq8mbzodx-uv64udiWmnJMS9wQw2pmeCsMRJyaRuWRBe8URUhoVNc0j9dRRQnBRjNFtdBt0ymmWdtRTM7Bm7nuwbtfyYQoBxu06Xs1GpeC5Osa0RrBDL76B9y75Mfcm0S1EHn_rM6QmCHtXQjedPLg7aD8SSIop4zkXk5RyCkKOWUk7zKSx2x9udRPzWDaB-MSSgZeL4AKWvWdV6O24YHjAjGBeebezdyt7c3pvxuQm8vd9Mr-cvbbEM3x3q_8z7wMsmby2-5abr9fvf_6-WYnMfkDZbq-ag</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Bülow Pedersen, Inge</creator><creator>Laurberg, Peter</creator><creator>Knudsen, Nils</creator><creator>Jørgensen, Torben</creator><creator>Perrild, Hans</creator><creator>Ovesen, Lars</creator><creator>Rasmussen, Lone Banke</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure</title><author>Bülow Pedersen, Inge ; Laurberg, Peter ; Knudsen, Nils ; Jørgensen, Torben ; Perrild, Hans ; Ovesen, Lars ; Rasmussen, Lone Banke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4624-2b3e595e6d8e0164eba28486fa4118c1994005f4a4332ec5a4c8cdbfa5c5df423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Iodide Peroxidase - immunology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyroiditis, Autoimmune - pathology</topic><topic>Thyroiditis, Autoimmune - physiopathology</topic><topic>Thyrotropin - blood</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bülow Pedersen, Inge</creatorcontrib><creatorcontrib>Laurberg, Peter</creatorcontrib><creatorcontrib>Knudsen, Nils</creatorcontrib><creatorcontrib>Jørgensen, Torben</creatorcontrib><creatorcontrib>Perrild, Hans</creatorcontrib><creatorcontrib>Ovesen, Lars</creatorcontrib><creatorcontrib>Rasmussen, Lone Banke</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bülow Pedersen, Inge</au><au>Laurberg, Peter</au><au>Knudsen, Nils</au><au>Jørgensen, Torben</au><au>Perrild, Hans</au><au>Ovesen, Lars</au><au>Rasmussen, Lone Banke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2005-06</date><risdate>2005</risdate><volume>62</volume><issue>6</issue><spage>713</spage><epage>720</epage><pages>713-720</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism.
Design A population study including 4649 randomly selected subjects.
Measurements Blood tests were used to analyse for thyroid peroxidase autoantibodies (TPO‐Ab), thyroglobulin autoantibodies (Tg‐Ab), TSH, fT3 and fT4.
Results Thyroid volume was categorized as small (< 6·6 ml) in 4·7%, normal (6·6–14·9 ml) in 60·4% and large (> 14·9 ml) in 34·9% of participants. Thyroid nodules were found in 29·7%. Serum TSH was low (< 0·4 mIU/l) in 4·7%, normal (0·4–3·6) in 91·0% and high (> 3·6) in 4·3%. The prevalence rate of subclinical goitrous Hashimoto's disease was 0·62% and of subclinical autoimmune atrophic thyroiditis 0·24%. There was a strong association between large volume and autoantibodies, but only in subjects with elevated TSH (P < 0·001). An association between thyroid nodules and TPO‐Ab in univariate analyses (P < 0·001) was due to confounding by sex and age (multivariate model, P = 0·23).
Conclusion We identified a subgroup of the population with subclinical goitrous Hashimoto's disease and a smaller subgroup with subclinical autoimmune atrophic thyroiditis. This relationship between small and large thyroid volume in subclinical disease is opposite to that in overt disease, which may suggest that the period between development of a small volume with circulating autoantibodies and overt hypothyroidism is relatively short.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15943834</pmid><doi>10.1111/j.1365-2265.2005.02284.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Autoantibodies - blood Biological and medical sciences Biomarkers - blood Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Iodide Peroxidase - immunology Logistic Models Male Medical sciences Middle Aged Thyroglobulin - immunology Thyroid Gland - pathology Thyroid Gland - physiopathology Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - pathology Thyroiditis, Autoimmune - physiopathology Thyrotropin - blood Vertebrates: endocrinology |
| title | A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure |
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