Ki-67 proliferative marker in lymph node aspirates of patients with non-Hodgkin's lymphoma
Proliferative activity of lymphoma cells was tested by immunocytochemical staining with Ki-67 monoclonal antibody in 63 aspirates of peripheral lymph nodes sampled from patients suffering from non-Hodgkin's lymphoma. Referring to the dominant cell population in nodal aspirates, a rising trend o...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2006, Vol.23 (1), p.83-90 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Mihaljevic, B. Nedeljkov-Jancic, R. Cemerikic-Martinovic, V. Babic, D. Colovic, M. |
| description | Proliferative activity of lymphoma cells was tested by immunocytochemical staining with Ki-67 monoclonal antibody in 63 aspirates of peripheral lymph nodes sampled from patients suffering from non-Hodgkin's lymphoma. Referring to the dominant cell population in nodal aspirates, a rising trend of Ki-67 proliferative marker was noted from the small cells (X = 13.20) and small cells with notched nucleus (X = 43.52) and large cells (X = 79.47) with histopathologic equivalents corresponding to aggressive lymphoma. Statistical testing of the difference in the Ki-67 proliferative marker against demographic and clinical-laboratory characteristics of the studied patients revealed the levels of significance for the performance status, bone marrow infiltration, and albumin serum value. Correlation of cytomorphological and immunocytochemical results was tested against International Prognostic Index (IPI). Statistically significant correlation of Ki-67 with cytomorphology and REAL-immunocytochemical classification of lymphoma was confirmed, but not with the IPI index. In order to determine the prognostic importance of Ki-67 marker, the patients were classified into those with low Ki-67 ( |
| doi_str_mv | 10.1385/MO:23:1:83 |
| format | Article |
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Referring to the dominant cell population in nodal aspirates, a rising trend of Ki-67 proliferative marker was noted from the small cells (X = 13.20) and small cells with notched nucleus (X = 43.52) and large cells (X = 79.47) with histopathologic equivalents corresponding to aggressive lymphoma. Statistical testing of the difference in the Ki-67 proliferative marker against demographic and clinical-laboratory characteristics of the studied patients revealed the levels of significance for the performance status, bone marrow infiltration, and albumin serum value. Correlation of cytomorphological and immunocytochemical results was tested against International Prognostic Index (IPI). Statistically significant correlation of Ki-67 with cytomorphology and REAL-immunocytochemical classification of lymphoma was confirmed, but not with the IPI index. In order to determine the prognostic importance of Ki-67 marker, the patients were classified into those with low Ki-67 (<20% of proliferating cells), mean proliferation index Ki-67 (range 20-59%), and high proliferative index Ki-67 (positive in over 60% of lymphoma cells). Testing Ki-67 with survival we have found that the low proliferative index was associated with the longest survival, median about 36 mo; for proliferative marker values ranging between 20 and 59%, the median survival was 30.4 mo; and survival of patients with the high proliferative index was only 12.9 mo.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1385/MO:23:1:83</identifier><identifier>PMID: 16645233</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Aged ; Biopsy, Needle ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Lymph Nodes - chemistry ; Lymphoma, Non-Hodgkin - mortality ; Lymphoma, Non-Hodgkin - pathology ; Male ; Middle Aged ; Oncology</subject><ispartof>Medical oncology (Northwood, London, England), 2006, Vol.23 (1), p.83-90</ispartof><rights>Humana Press Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-260a8c6d53876cec2d5c83ed49522579a963a8ce9bcb5009bbcc5d5775b73f373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16645233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mihaljevic, B.</creatorcontrib><creatorcontrib>Nedeljkov-Jancic, R.</creatorcontrib><creatorcontrib>Cemerikic-Martinovic, V.</creatorcontrib><creatorcontrib>Babic, D.</creatorcontrib><creatorcontrib>Colovic, M.</creatorcontrib><title>Ki-67 proliferative marker in lymph node aspirates of patients with non-Hodgkin's lymphoma</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><description>Proliferative activity of lymphoma cells was tested by immunocytochemical staining with Ki-67 monoclonal antibody in 63 aspirates of peripheral lymph nodes sampled from patients suffering from non-Hodgkin's lymphoma. Referring to the dominant cell population in nodal aspirates, a rising trend of Ki-67 proliferative marker was noted from the small cells (X = 13.20) and small cells with notched nucleus (X = 43.52) and large cells (X = 79.47) with histopathologic equivalents corresponding to aggressive lymphoma. Statistical testing of the difference in the Ki-67 proliferative marker against demographic and clinical-laboratory characteristics of the studied patients revealed the levels of significance for the performance status, bone marrow infiltration, and albumin serum value. Correlation of cytomorphological and immunocytochemical results was tested against International Prognostic Index (IPI). Statistically significant correlation of Ki-67 with cytomorphology and REAL-immunocytochemical classification of lymphoma was confirmed, but not with the IPI index. In order to determine the prognostic importance of Ki-67 marker, the patients were classified into those with low Ki-67 (<20% of proliferating cells), mean proliferation index Ki-67 (range 20-59%), and high proliferative index Ki-67 (positive in over 60% of lymphoma cells). Testing Ki-67 with survival we have found that the low proliferative index was associated with the longest survival, median about 36 mo; for proliferative marker values ranging between 20 and 59%, the median survival was 30.4 mo; and survival of patients with the high proliferative index was only 12.9 mo.</description><subject>Adult</subject><subject>Aged</subject><subject>Biopsy, Needle</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Lymph Nodes - chemistry</subject><subject>Lymphoma, Non-Hodgkin - mortality</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oncology</subject><issn>1357-0560</issn><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0M9LwzAUB_AgipvTi3-ABA8KQjU_mqTdTYa_cGMXvXgJaZpqtrapSafsvzdjA8XTC7xPHu99ATjF6BrTjN3M5mNCx3ic0T0wxJSJBDGO9v-8B-AohAVCBDOSH4IB5jxlhNIheHu2CRew8662lfGqt18GNsovjYe2hfW66T5g60oDVehs7JsAXQW7CE3bB_ht-02_TR5d-b607WXY_nGNOgYHlaqDOdnVEXi9v3uZPCbT-cPT5HaaaIpJnxCOVKZ5yWgmuDaalExn1JRpzghhIlc5pxGYvNAFQygvCq1ZyYRghaAVFXQELrZz4xGfKxN62digTV2r1rhVkFzkOGVoA8__wYVb-TbuJjPBGMdpiiO62iLtXQjeVLLzNgaylhjJTdxyNpeESiwzGvHZbuKqaEz5S3f50h8EpXn4</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Mihaljevic, B.</creator><creator>Nedeljkov-Jancic, R.</creator><creator>Cemerikic-Martinovic, V.</creator><creator>Babic, D.</creator><creator>Colovic, M.</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Ki-67 proliferative marker in lymph node aspirates of patients with non-Hodgkin's lymphoma</title><author>Mihaljevic, B. ; Nedeljkov-Jancic, R. ; Cemerikic-Martinovic, V. ; Babic, D. ; Colovic, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-260a8c6d53876cec2d5c83ed49522579a963a8ce9bcb5009bbcc5d5775b73f373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biopsy, Needle</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Lymph Nodes - chemistry</topic><topic>Lymphoma, Non-Hodgkin - mortality</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihaljevic, B.</creatorcontrib><creatorcontrib>Nedeljkov-Jancic, R.</creatorcontrib><creatorcontrib>Cemerikic-Martinovic, V.</creatorcontrib><creatorcontrib>Babic, D.</creatorcontrib><creatorcontrib>Colovic, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mihaljevic, B.</au><au>Nedeljkov-Jancic, R.</au><au>Cemerikic-Martinovic, V.</au><au>Babic, D.</au><au>Colovic, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ki-67 proliferative marker in lymph node aspirates of patients with non-Hodgkin's lymphoma</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><addtitle>Med Oncol</addtitle><date>2006</date><risdate>2006</risdate><volume>23</volume><issue>1</issue><spage>83</spage><epage>90</epage><pages>83-90</pages><issn>1357-0560</issn><eissn>1357-0560</eissn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>Proliferative activity of lymphoma cells was tested by immunocytochemical staining with Ki-67 monoclonal antibody in 63 aspirates of peripheral lymph nodes sampled from patients suffering from non-Hodgkin's lymphoma. Referring to the dominant cell population in nodal aspirates, a rising trend of Ki-67 proliferative marker was noted from the small cells (X = 13.20) and small cells with notched nucleus (X = 43.52) and large cells (X = 79.47) with histopathologic equivalents corresponding to aggressive lymphoma. Statistical testing of the difference in the Ki-67 proliferative marker against demographic and clinical-laboratory characteristics of the studied patients revealed the levels of significance for the performance status, bone marrow infiltration, and albumin serum value. Correlation of cytomorphological and immunocytochemical results was tested against International Prognostic Index (IPI). Statistically significant correlation of Ki-67 with cytomorphology and REAL-immunocytochemical classification of lymphoma was confirmed, but not with the IPI index. In order to determine the prognostic importance of Ki-67 marker, the patients were classified into those with low Ki-67 (<20% of proliferating cells), mean proliferation index Ki-67 (range 20-59%), and high proliferative index Ki-67 (positive in over 60% of lymphoma cells). Testing Ki-67 with survival we have found that the low proliferative index was associated with the longest survival, median about 36 mo; for proliferative marker values ranging between 20 and 59%, the median survival was 30.4 mo; and survival of patients with the high proliferative index was only 12.9 mo.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16645233</pmid><doi>10.1385/MO:23:1:83</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Biopsy, Needle Female Humans Immunohistochemistry Ki-67 Antigen - analysis Lymph Nodes - chemistry Lymphoma, Non-Hodgkin - mortality Lymphoma, Non-Hodgkin - pathology Male Middle Aged Oncology |
| title | Ki-67 proliferative marker in lymph node aspirates of patients with non-Hodgkin's lymphoma |
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