Protective Effect of the HLA-Bw4I80 Epitope and the Killer Cell Immunoglobulin-Like Receptor 3DS1 Gene against the Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection
The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer...
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| Veröffentlicht in: | The Journal of infectious diseases 2005-07, Vol.192 (1), p.162-165 |
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| creator | López-Vázquez, Antonio Rodrigo, Luis Martínez-Borra, Jesús Pérez, Ramón Rodríguez, Manuel Fdez-Morera, Juan L. Fuentes, Dolores Rodríguez-Rodero, Sandra González, Segundo López-Larrea, Carlos |
| description | The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen–Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other—the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22) |
| doi_str_mv | 10.1086/430351 |
| format | Article |
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Moreover, these associations were not independent of each other—the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22)</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/430351</identifier><identifier>PMID: 15942906</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Aged ; Alleles ; Biological and medical sciences ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - immunology ; Disease Progression ; Epitopes ; Epitopes - genetics ; Female ; Fundamental and applied biological sciences. 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Psychology</subject><subject>Genotype</subject><subject>Hepacivirus</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C virus</subject><subject>Hepatocellular carcinoma</subject><subject>HLA-B Antigens - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Killer Cells, Natural - immunology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Molecules</subject><subject>Natural killer cells</subject><subject>Receptors</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, KIR</subject><subject>Receptors, KIR3DS1</subject><subject>T lymphocytes</subject><subject>Tumors</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9u0zAUxiMEYmPAG4A8JLgL-E8S25ejLWtFBdMGaOImctKTzV1iB9vZ4Al5LdymWiUkxJUtfb_znWN_J0meE_yWYFG8yxhmOXmQHJKc8bQoCHuYHGJMaUqElAfJE-_XGOOMFfxxckBymVGJi8Pk95mzAeqgbwHNmibekG1QuAY0X56k7--yhcBo1utge0DKrLbSR9224NAE2hYtum4w9qq11dBqky71DaBzqKEP1iE2vSDoFEwsvVLa-LAtn8IttLbvwGybzaFXwdbRbGhVdFWu1sZ2CmmDzlTQEfPoTofrkdRBezRB37QbPFqYzcjamqfJo0a1Hp7tzqPk64fZl8k8XX4-XUxOlmmd5SSkvMB51eRNk4ma4lyxpqiBUEVZTYkAJSglwCUjfCWbLJdVlXFGIlKBwpIqdpS8GX17Z38M4EPZab-ZXRmwgy8LLkmMQPwXJFwUgkoewVd_gWs7OBMfUVLKJBaE4r1b7az3Dpqyd7pT7ldJcLlZgHJcgAi-3LkNVQerPbZLPAKvd4DytWobp0yt_Z7jcUsKlkXueOTs0P-72YuRWfuY9j3FMBYcSxn1dNS1D_DzXlfuJv4T43k5v_xeUnnxSRTT8_KS_QFgsdo5</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>López-Vázquez, Antonio</creator><creator>Rodrigo, Luis</creator><creator>Martínez-Borra, Jesús</creator><creator>Pérez, Ramón</creator><creator>Rodríguez, Manuel</creator><creator>Fdez-Morera, Juan L.</creator><creator>Fuentes, Dolores</creator><creator>Rodríguez-Rodero, Sandra</creator><creator>González, Segundo</creator><creator>López-Larrea, Carlos</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Protective Effect of the HLA-Bw4I80 Epitope and the Killer Cell Immunoglobulin-Like Receptor 3DS1 Gene against the Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection</title><author>López-Vázquez, Antonio ; Rodrigo, Luis ; Martínez-Borra, Jesús ; Pérez, Ramón ; Rodríguez, Manuel ; Fdez-Morera, Juan L. ; Fuentes, Dolores ; Rodríguez-Rodero, Sandra ; González, Segundo ; López-Larrea, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-7605bf5ff48c205a3f6ce12a23c218ea8221e79317d9f459bb4731ce1bea092a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - immunology</topic><topic>Disease Progression</topic><topic>Epitopes</topic><topic>Epitopes - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Hepacivirus</topic><topic>Hepatitis C - genetics</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C virus</topic><topic>Hepatocellular carcinoma</topic><topic>HLA-B Antigens - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Killer Cells, Natural - immunology</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Molecules</topic><topic>Natural killer cells</topic><topic>Receptors</topic><topic>Receptors, Immunologic - genetics</topic><topic>Receptors, KIR</topic><topic>Receptors, KIR3DS1</topic><topic>T lymphocytes</topic><topic>Tumors</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Vázquez, Antonio</creatorcontrib><creatorcontrib>Rodrigo, Luis</creatorcontrib><creatorcontrib>Martínez-Borra, Jesús</creatorcontrib><creatorcontrib>Pérez, Ramón</creatorcontrib><creatorcontrib>Rodríguez, Manuel</creatorcontrib><creatorcontrib>Fdez-Morera, Juan L.</creatorcontrib><creatorcontrib>Fuentes, Dolores</creatorcontrib><creatorcontrib>Rodríguez-Rodero, Sandra</creatorcontrib><creatorcontrib>González, Segundo</creatorcontrib><creatorcontrib>López-Larrea, Carlos</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Vázquez, Antonio</au><au>Rodrigo, Luis</au><au>Martínez-Borra, Jesús</au><au>Pérez, Ramón</au><au>Rodríguez, Manuel</au><au>Fdez-Morera, Juan L.</au><au>Fuentes, Dolores</au><au>Rodríguez-Rodero, Sandra</au><au>González, Segundo</au><au>López-Larrea, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of the HLA-Bw4I80 Epitope and the Killer Cell Immunoglobulin-Like Receptor 3DS1 Gene against the Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>192</volume><issue>1</issue><spage>162</spage><epage>165</epage><pages>162-165</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen–Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other—the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22)</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15942906</pmid><doi>10.1086/430351</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2005-07, Vol.192 (1), p.162-165 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Alleles Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - immunology Disease Progression Epitopes Epitopes - genetics Female Fundamental and applied biological sciences. Psychology Genotype Hepacivirus Hepatitis C - genetics Hepatitis C - immunology Hepatitis C virus Hepatocellular carcinoma HLA-B Antigens - genetics Human viral diseases Humans Infections Infectious diseases Killer Cells, Natural - immunology Liver cirrhosis Liver Cirrhosis - immunology Male Medical sciences Microbiology Middle Aged Molecules Natural killer cells Receptors Receptors, Immunologic - genetics Receptors, KIR Receptors, KIR3DS1 T lymphocytes Tumors Viral diseases Viral hepatitis Viruses |
| title | Protective Effect of the HLA-Bw4I80 Epitope and the Killer Cell Immunoglobulin-Like Receptor 3DS1 Gene against the Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection |
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