Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband’s mononuclear cells
To elucidate the possible mechanisms of immunotherapy for unexplained recurrent aborters using their husband’s mononuclear cells. Prospective clinical study. Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital. Fifty-two unexplained recurrent aborters...
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| Veröffentlicht in: | Fertility and sterility 2006-05, Vol.85 (5), p.1452-1458 |
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| container_title | Fertility and sterility |
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| creator | Yokoo, Tomokazu Takakuwa, Koichi Ooki, Izumi Kikuchi, Akira Tamura, Masaki Tanaka, Kenichi |
| description | To elucidate the possible mechanisms of immunotherapy for unexplained recurrent aborters using their husband’s mononuclear cells.
Prospective clinical study.
Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital.
Fifty-two unexplained recurrent aborters were chosen as an experimental group.
Each patient was injected with her husband’s mononuclear cells as immunotherapy. Peripheral blood was obtained from the patients.
The percentage of CD4-positive cells, TH1 cells, TH2 cells, and the TH1/TH2 ratio were analyzed in the patients before and after immunotherapy. The same analyses were performed in the successful and the unsuccessful group.
To date, 42 of the 52 patients have become newly pregnant. Of the 42, 34 patients have already delivered (successful group) and 3 are now pregnant, while the remaining 8 cases experienced repeated abortion (unsuccessful group). The percentage of TH2 cells significantly increased in the total patient population, while the TH1/TH2 ratio significantly decreased in the total patient population and in the successful group.
These findings suggest that immunotherapy with the husband’s mononuclear cells for unexplained recurrent abortion induces a dominant state of TH2 cells in the patients. |
| doi_str_mv | 10.1016/j.fertnstert.2005.10.058 |
| format | Article |
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Prospective clinical study.
Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital.
Fifty-two unexplained recurrent aborters were chosen as an experimental group.
Each patient was injected with her husband’s mononuclear cells as immunotherapy. Peripheral blood was obtained from the patients.
The percentage of CD4-positive cells, TH1 cells, TH2 cells, and the TH1/TH2 ratio were analyzed in the patients before and after immunotherapy. The same analyses were performed in the successful and the unsuccessful group.
To date, 42 of the 52 patients have become newly pregnant. Of the 42, 34 patients have already delivered (successful group) and 3 are now pregnant, while the remaining 8 cases experienced repeated abortion (unsuccessful group). The percentage of TH2 cells significantly increased in the total patient population, while the TH1/TH2 ratio significantly decreased in the total patient population and in the successful group.
These findings suggest that immunotherapy with the husband’s mononuclear cells for unexplained recurrent abortion induces a dominant state of TH2 cells in the patients.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2005.10.058</identifier><identifier>PMID: 16647376</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abortion, Habitual - immunology ; Abortion, Habitual - therapy ; Biological and medical sciences ; Cytokines - immunology ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; immunotherapy ; Immunotherapy - methods ; Lymphocyte Transfusion - methods ; Lymphocytes - immunology ; Male ; mechanisms ; Medical sciences ; Pregnancy. Fetus. Placenta ; Spouses ; TH1 ; Th1 Cells - immunology ; TH2 ; Th2 Cells - immunology ; Treatment Outcome ; Unexplained recurrent abortion</subject><ispartof>Fertility and sterility, 2006-05, Vol.85 (5), p.1452-1458</ispartof><rights>2006 American Society for Reproductive Medicine</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-f73d1eff8d04cacec02bad66ee098b1d4df9d79326bffd373184c66dfd2c2cd93</citedby><cites>FETCH-LOGICAL-c452t-f73d1eff8d04cacec02bad66ee098b1d4df9d79326bffd373184c66dfd2c2cd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2005.10.058$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17758747$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16647376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokoo, Tomokazu</creatorcontrib><creatorcontrib>Takakuwa, Koichi</creatorcontrib><creatorcontrib>Ooki, Izumi</creatorcontrib><creatorcontrib>Kikuchi, Akira</creatorcontrib><creatorcontrib>Tamura, Masaki</creatorcontrib><creatorcontrib>Tanaka, Kenichi</creatorcontrib><title>Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband’s mononuclear cells</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To elucidate the possible mechanisms of immunotherapy for unexplained recurrent aborters using their husband’s mononuclear cells.
Prospective clinical study.
Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital.
Fifty-two unexplained recurrent aborters were chosen as an experimental group.
Each patient was injected with her husband’s mononuclear cells as immunotherapy. Peripheral blood was obtained from the patients.
The percentage of CD4-positive cells, TH1 cells, TH2 cells, and the TH1/TH2 ratio were analyzed in the patients before and after immunotherapy. The same analyses were performed in the successful and the unsuccessful group.
To date, 42 of the 52 patients have become newly pregnant. Of the 42, 34 patients have already delivered (successful group) and 3 are now pregnant, while the remaining 8 cases experienced repeated abortion (unsuccessful group). The percentage of TH2 cells significantly increased in the total patient population, while the TH1/TH2 ratio significantly decreased in the total patient population and in the successful group.
These findings suggest that immunotherapy with the husband’s mononuclear cells for unexplained recurrent abortion induces a dominant state of TH2 cells in the patients.</description><subject>Abortion, Habitual - immunology</subject><subject>Abortion, Habitual - therapy</subject><subject>Biological and medical sciences</subject><subject>Cytokines - immunology</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Lymphocyte Transfusion - methods</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>mechanisms</subject><subject>Medical sciences</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Spouses</subject><subject>TH1</subject><subject>Th1 Cells - immunology</subject><subject>TH2</subject><subject>Th2 Cells - immunology</subject><subject>Treatment Outcome</subject><subject>Unexplained recurrent abortion</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGOFCEQhonRuOPoKxgueusR6G7oOa4b3TXZxMt6JjQUGcZuaIHWnZuv4aPs6_gk0jOTzNELlaK-qvrhRwhTsqGE8g_7jYWYfcrl3DBC2nK9IW33DK1o2_Kq5W39HK0IoW1FWMeu0KuU9oQQTgV7ia4o542oBV-hp-uhDFHZBY-DxQ93FCtvSmRYwzAk3B-w8zmqJZsHFbE-5PDdecAGMuhjo_N4KiPA54R_ubzDs4fHaVCFMjiCnmMsNaz6EI98DzZEOC5StqzHbhxnH_KuKJkOpxElwbs59QX6-_tPwmPwwc96gEXCouw1emHVkODNOa7Rt8-fHm7uqvuvt19uru8r3bQsV1bUhoK1nSGNLq_QhPXKcA5Atl1PTWPs1ohtzXhvralFTbtGc26sYZpps63X6P1p7hTDjxlSlqNLiwLlIcxJcrGltCFNAbsTqGNIKYKVU3SjigdJiVxsk3t5sU0uti2VYltpfXveMfcjmEvj2acCvDsDKmk12Ki8dunCCdF2oqBr9PHEQfmRnw6iTLr4osG44kOWJrj_q_kHVJ_DZw</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Yokoo, Tomokazu</creator><creator>Takakuwa, Koichi</creator><creator>Ooki, Izumi</creator><creator>Kikuchi, Akira</creator><creator>Tamura, Masaki</creator><creator>Tanaka, Kenichi</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband’s mononuclear cells</title><author>Yokoo, Tomokazu ; Takakuwa, Koichi ; Ooki, Izumi ; Kikuchi, Akira ; Tamura, Masaki ; Tanaka, Kenichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-f73d1eff8d04cacec02bad66ee098b1d4df9d79326bffd373184c66dfd2c2cd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Abortion, Habitual - immunology</topic><topic>Abortion, Habitual - therapy</topic><topic>Biological and medical sciences</topic><topic>Cytokines - immunology</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Lymphocyte Transfusion - methods</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>mechanisms</topic><topic>Medical sciences</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Spouses</topic><topic>TH1</topic><topic>Th1 Cells - immunology</topic><topic>TH2</topic><topic>Th2 Cells - immunology</topic><topic>Treatment Outcome</topic><topic>Unexplained recurrent abortion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokoo, Tomokazu</creatorcontrib><creatorcontrib>Takakuwa, Koichi</creatorcontrib><creatorcontrib>Ooki, Izumi</creatorcontrib><creatorcontrib>Kikuchi, Akira</creatorcontrib><creatorcontrib>Tamura, Masaki</creatorcontrib><creatorcontrib>Tanaka, Kenichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokoo, Tomokazu</au><au>Takakuwa, Koichi</au><au>Ooki, Izumi</au><au>Kikuchi, Akira</au><au>Tamura, Masaki</au><au>Tanaka, Kenichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband’s mononuclear cells</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>85</volume><issue>5</issue><spage>1452</spage><epage>1458</epage><pages>1452-1458</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To elucidate the possible mechanisms of immunotherapy for unexplained recurrent aborters using their husband’s mononuclear cells.
Prospective clinical study.
Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital.
Fifty-two unexplained recurrent aborters were chosen as an experimental group.
Each patient was injected with her husband’s mononuclear cells as immunotherapy. Peripheral blood was obtained from the patients.
The percentage of CD4-positive cells, TH1 cells, TH2 cells, and the TH1/TH2 ratio were analyzed in the patients before and after immunotherapy. The same analyses were performed in the successful and the unsuccessful group.
To date, 42 of the 52 patients have become newly pregnant. Of the 42, 34 patients have already delivered (successful group) and 3 are now pregnant, while the remaining 8 cases experienced repeated abortion (unsuccessful group). The percentage of TH2 cells significantly increased in the total patient population, while the TH1/TH2 ratio significantly decreased in the total patient population and in the successful group.
These findings suggest that immunotherapy with the husband’s mononuclear cells for unexplained recurrent abortion induces a dominant state of TH2 cells in the patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16647376</pmid><doi>10.1016/j.fertnstert.2005.10.058</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Abortion, Habitual - immunology Abortion, Habitual - therapy Biological and medical sciences Cytokines - immunology Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans immunotherapy Immunotherapy - methods Lymphocyte Transfusion - methods Lymphocytes - immunology Male mechanisms Medical sciences Pregnancy. Fetus. Placenta Spouses TH1 Th1 Cells - immunology TH2 Th2 Cells - immunology Treatment Outcome Unexplained recurrent abortion |
| title | Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband’s mononuclear cells |
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