Bis(trimethoxysilylpropyl)amine and tetraethoxysilane derived gels as effective controlled release carriers for water-soluble drugs of small molecules
The controlled release of sodium salicylate (SS) from the gels derived from bis(trimethoxysilylpropyl)amine (TSPA) or the mixture of TSPA with tetraethoxysilane (TEOS) was investigated. The experimental results suggest that the release of SS can be easily controlled by adjusting the ratio between TS...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2006-04, Vol.49 (1), p.55-59 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Jiang, Yan Wu, Zhijian You, Laijiang Xiang, Hong |
| description | The controlled release of sodium salicylate (SS) from the gels derived from bis(trimethoxysilylpropyl)amine (TSPA) or the mixture of TSPA with tetraethoxysilane (TEOS) was investigated. The experimental results suggest that the release of SS can be easily controlled by adjusting the ratio between TSPA and TEOS. Increasing the ratio between TSPA and TEOS lowers the surface area and pore volume of the gels, while enhances the interactions between the drug and the gel matrix. Therefore, reduces the release rate of the drug effectively. The overall release process is found to be diffusion controlled, and the release behavior can be well explained by considering the effects of the textual properties of the gels and the interactions between the drug and the gel matrix. TSPA is found to be a very convenient and effective precursor for the preparation of gels for controlled release of both hydrophilic and hydrophobic drugs, especially water-soluble drugs of small molecules. |
| doi_str_mv | 10.1016/j.colsurfb.2006.02.012 |
| format | Article |
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The experimental results suggest that the release of SS can be easily controlled by adjusting the ratio between TSPA and TEOS. Increasing the ratio between TSPA and TEOS lowers the surface area and pore volume of the gels, while enhances the interactions between the drug and the gel matrix. Therefore, reduces the release rate of the drug effectively. The overall release process is found to be diffusion controlled, and the release behavior can be well explained by considering the effects of the textual properties of the gels and the interactions between the drug and the gel matrix. 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The experimental results suggest that the release of SS can be easily controlled by adjusting the ratio between TSPA and TEOS. Increasing the ratio between TSPA and TEOS lowers the surface area and pore volume of the gels, while enhances the interactions between the drug and the gel matrix. Therefore, reduces the release rate of the drug effectively. The overall release process is found to be diffusion controlled, and the release behavior can be well explained by considering the effects of the textual properties of the gels and the interactions between the drug and the gel matrix. TSPA is found to be a very convenient and effective precursor for the preparation of gels for controlled release of both hydrophilic and hydrophobic drugs, especially water-soluble drugs of small molecules.</description><subject>Bis(trimethoxysilylpropyl)amine</subject><subject>Drug Carriers - chemistry</subject><subject>Electrostatic attraction</subject><subject>Gel</subject><subject>Gels - chemistry</subject><subject>Hydrophobic attraction</subject><subject>Molecular Structure</subject><subject>Molecular Weight</subject><subject>Organosilicon Compounds - chemistry</subject><subject>Propylamines - chemistry</subject><subject>Silanes - chemistry</subject><subject>Sodium salicylate</subject><subject>Sodium Salicylate - chemistry</subject><subject>Solubility</subject><subject>Surface Properties</subject><subject>Tetraethoxysilane</subject><subject>Textural property</subject><subject>Time Factors</subject><subject>Water - chemistry</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRS0EYpqBXxh5hWCR4EcSOzuYES9pJDawthy7PLjltBtXMtA_wvfiVjewnFVJt05Vqe4l5IqzljM-vNm2LidcS5hawdjQMtEyLh6RDddKNp0c1GOyYaNQjVJDf0GeIW4ZY6Lj6im54EOvO63Ehvy-jvhqKXGG5Xv-dcCYDmlf8v6QXts57oDanacLLMX-A2xVPZR4D57eQUJqkUII4JYqUZd3S8kp1WaBBBarZEuJUJCGXOhPu0BpMKd1SnVPWe-Q5kBxtinROSdwawJ8Tp4EmxBenOsl-fbh_debT83tl4-fb97dNk6OamnkNHEdJu20H6x0Y89Hq-0wBeWs1b7T2vlRT33QoIWV48il74WYpLZdZ6GXl-TlaW_9-ccKuJg5ooN0fDKvaAY1ci6EeBDkYyd72akKDifQlYxYIJh9ddeWg-HMHKMzW_M3OnOMzjBhanR18Op8YZ1m8P_HzllV4O0JqJ7DfTXUoIuwc-BjqeYbn-NDN_4AQfmzqw</recordid><startdate>20060415</startdate><enddate>20060415</enddate><creator>Jiang, Yan</creator><creator>Wu, Zhijian</creator><creator>You, Laijiang</creator><creator>Xiang, Hong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060415</creationdate><title>Bis(trimethoxysilylpropyl)amine and tetraethoxysilane derived gels as effective controlled release carriers for water-soluble drugs of small molecules</title><author>Jiang, Yan ; Wu, Zhijian ; You, Laijiang ; Xiang, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-3bb18fb8c8d6a3c9519a8a6bf7caa8d488cd98b5f8e82a39913d522b38a44ae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Bis(trimethoxysilylpropyl)amine</topic><topic>Drug Carriers - chemistry</topic><topic>Electrostatic attraction</topic><topic>Gel</topic><topic>Gels - chemistry</topic><topic>Hydrophobic attraction</topic><topic>Molecular Structure</topic><topic>Molecular Weight</topic><topic>Organosilicon Compounds - chemistry</topic><topic>Propylamines - chemistry</topic><topic>Silanes - chemistry</topic><topic>Sodium salicylate</topic><topic>Sodium Salicylate - chemistry</topic><topic>Solubility</topic><topic>Surface Properties</topic><topic>Tetraethoxysilane</topic><topic>Textural property</topic><topic>Time Factors</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yan</creatorcontrib><creatorcontrib>Wu, Zhijian</creatorcontrib><creatorcontrib>You, Laijiang</creatorcontrib><creatorcontrib>Xiang, Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yan</au><au>Wu, Zhijian</au><au>You, Laijiang</au><au>Xiang, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bis(trimethoxysilylpropyl)amine and tetraethoxysilane derived gels as effective controlled release carriers for water-soluble drugs of small molecules</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2006-04-15</date><risdate>2006</risdate><volume>49</volume><issue>1</issue><spage>55</spage><epage>59</epage><pages>55-59</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>The controlled release of sodium salicylate (SS) from the gels derived from bis(trimethoxysilylpropyl)amine (TSPA) or the mixture of TSPA with tetraethoxysilane (TEOS) was investigated. The experimental results suggest that the release of SS can be easily controlled by adjusting the ratio between TSPA and TEOS. Increasing the ratio between TSPA and TEOS lowers the surface area and pore volume of the gels, while enhances the interactions between the drug and the gel matrix. Therefore, reduces the release rate of the drug effectively. The overall release process is found to be diffusion controlled, and the release behavior can be well explained by considering the effects of the textual properties of the gels and the interactions between the drug and the gel matrix. TSPA is found to be a very convenient and effective precursor for the preparation of gels for controlled release of both hydrophilic and hydrophobic drugs, especially water-soluble drugs of small molecules.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16584872</pmid><doi>10.1016/j.colsurfb.2006.02.012</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0927-7765 |
| ispartof | Colloids and surfaces, B, Biointerfaces, 2006-04, Vol.49 (1), p.55-59 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Bis(trimethoxysilylpropyl)amine Drug Carriers - chemistry Electrostatic attraction Gel Gels - chemistry Hydrophobic attraction Molecular Structure Molecular Weight Organosilicon Compounds - chemistry Propylamines - chemistry Silanes - chemistry Sodium salicylate Sodium Salicylate - chemistry Solubility Surface Properties Tetraethoxysilane Textural property Time Factors Water - chemistry |
| title | Bis(trimethoxysilylpropyl)amine and tetraethoxysilane derived gels as effective controlled release carriers for water-soluble drugs of small molecules |
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