Emergence of Drug-Resistant HIV-1 after Intrapartum Administration of Single-Dose Nevirapine Is Substantially Underestimated

Conventional sequence analysis detects human immunodeficiency virus (HIV)–1 drug resistance mutations in ∼40% of women shortly after they receive intrapartum single-dose nevirapine (SD-NVP). Using sensitive real-time polymerase chain reaction assays for the K103N and Y181C resistance mutations, we t...

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Veröffentlicht in:	The Journal of infectious diseases 2005-07, Vol.192 (1), p.16-23
Hauptverfasser:	Johnson, Jeffrey A., Li, Jin-fen, Morris, Lynn, Martinson, Neil, Gray, Glenda, McIntyre, James, Heneine, Walid
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacology Drug Administration Schedule Drug Resistance, Viral Female Genetic mutation Health care administration HIV HIV 1 HIV Infections - prevention & control HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV/AIDS Human immunodeficiency virus 1 Humans Infectious Disease Transmission, Vertical - prevention & control Mutation Nevirapine - administration & dosage Nevirapine - pharmacology Polymerase chain reaction Pregnancy Reactivity Sequence analysis Standardized tests Viral Proteins - genetics Viruses Women
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