Modulation of antigen-specific T cell response by a non-mitogenic anti-CD3 antibody

Suppression of T cell response is the key to enhance graft survival and control autoimmune diseases. A mitogenic anti-CD3 monoclonal antibody (mAb), OKT3, has been used for decades to control acute rejection in organ transplantation. Although effective, the clinical use was limited by its side effec...

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Veröffentlicht in:	International immunopharmacology 2006-06, Vol.6 (6), p.880-891
Hauptverfasser:	Li, Jian, Davis, Janet, Bracht, Michelle, Carton, Jill, Armstrong, Jennifer, Gao, Wei, Scallon, Bernie, Fung, Ramie, Emmell, Eva, Zimmerman, Mark, Griswold, Don E., Li, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-CD3 antibody Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Apoptosis - drug effects Apoptosis - immunology Biological and medical sciences CD3 Complex - immunology Cell Proliferation - drug effects Cytokines Cytokines - blood Cytokines - metabolism Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - surgery Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance fas Receptor - metabolism Graft Survival - drug effects Graft Survival - immunology Humans Immune suppression Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Immunosuppressive Agents - pharmacology Islet transplantation Islets of Langerhans Transplantation - immunology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lymphocyte Activation - drug effects Lymphocyte Count Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Muromonab-CD3 - pharmacology Pharmacology. Drug treatments Protein Binding Receptors, Fc - metabolism T cells T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology U937 Cells
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