Functional characterization of hepatocyte nuclear factor‐4α dimerization interface mutants

Hepatocyte nuclear factor‐4 (HNF‐4α), a member of the nuclear receptor superfamily, binds DNA exclusively as a homodimer. Dimerization controls important aspects of receptor function, such as DNA binding, protein stability, ligand binding and interaction with coactivators. Crystallographic data of t...

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Veröffentlicht in:	The FEBS journal 2006-05, Vol.273 (9), p.1948-1958
Hauptverfasser:	Aggelidou, Eleni, Iordanidou, Panagiota, Demetriades, Constantinos, Piltsi, Olga, Hadzopoulou‐Cladaras, Margarita
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution - genetics Animals Chlorocebus aethiops coactivator COS Cells Dimerization DNA - metabolism Hepatocyte Nuclear Factor 4 - chemistry Hepatocyte Nuclear Factor 4 - genetics Hepatocyte Nuclear Factor 4 - metabolism Hepatocyte Nuclear Factor 4 - physiology HNF‐4 Humans Molecular Sequence Data Mutation nuclear receptor Protein Binding - genetics Rats transcription
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