Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation
Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region,...
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| Veröffentlicht in: | Transplantation 2006-04, Vol.81 (8), p.1153-1156 |
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| creator | FRISALDI, Elisa CONCA, Raffaele MAGISTRONI, Paola FASANO, Maria Edvige MAZZOLA, Gina PATANE, Francesco ZINGARELLI, Edoardo DALL'OMO, Anna M BRUSCO, Alfredo AMOROSO, Antonio |
| description | Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT)n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30 |
| doi_str_mv | 10.1097/01.tp.0000205181.31604.09 |
| format | Article |
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Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT)n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30<or=30 U/ml displayed a significantly better survival. In conclusion, sCD30 levels are predictive of HT outcome.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.tp.0000205181.31604.09</identifier><identifier>PMID: 16641601</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Heart Transplantation - mortality ; Humans ; Ki-1 Antigen - blood ; Ki-1 Antigen - genetics ; Male ; Medical sciences ; Microsatellite Repeats ; Middle Aged ; Polymorphism, Genetic ; Prognosis ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology</subject><ispartof>Transplantation, 2006-04, Vol.81 (8), p.1153-1156</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-3855aa65e40c09461ec90f92e40f55211d089bc474521d1beb0152c1925310773</citedby><cites>FETCH-LOGICAL-c427t-3855aa65e40c09461ec90f92e40f55211d089bc474521d1beb0152c1925310773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17775227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16641601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRISALDI, Elisa</creatorcontrib><creatorcontrib>CONCA, Raffaele</creatorcontrib><creatorcontrib>MAGISTRONI, Paola</creatorcontrib><creatorcontrib>FASANO, Maria Edvige</creatorcontrib><creatorcontrib>MAZZOLA, Gina</creatorcontrib><creatorcontrib>PATANE, Francesco</creatorcontrib><creatorcontrib>ZINGARELLI, Edoardo</creatorcontrib><creatorcontrib>DALL'OMO, Anna M</creatorcontrib><creatorcontrib>BRUSCO, Alfredo</creatorcontrib><creatorcontrib>AMOROSO, Antonio</creatorcontrib><title>Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT)n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30<or=30 U/ml displayed a significantly better survival. In conclusion, sCD30 levels are predictive of HT outcome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Heart Transplantation - mortality</subject><subject>Humans</subject><subject>Ki-1 Antigen - blood</subject><subject>Ki-1 Antigen - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Prognosis</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAQgC0E6m5p_wJyD_SWMBPbcXxE2xcSEhzaXi3H67CpkjjYDtL-e0x3pT0yl5mRvnnoI-QLQomg5A1gmeYSclQgsMGSYQ28BHVG1igYL2po4JysATgWyJhckY8x_su8YFJ-ICusa55HcE3-Pgb_NPmYektfzLC4SH1Hox-WdnB0840BNdP2UDy5ydHZD_vRh3nXxzHSfqI7Z0KiKZgpzoOZkkm9nz6Ri84M0X0-5kvy58f335tfxf3Dz7vN7X1heSVTwRohjKmF42BB8RqdVdCpKvedEBXiFhrVWi55brbYuhZQVBZVJRiClOySfD3snYN_zs8nPfbRuiE_4vwSdS0VyIard8G8UklEzKA6gDb4GIPr9Bz60YS9RtBv9jWgTrM-2df_7Wt4O3J1PLK0o9ueJo-6M3B9BEy0ZuiyNNvHEyelFFUl2SuiEYuz</recordid><startdate>20060427</startdate><enddate>20060427</enddate><creator>FRISALDI, Elisa</creator><creator>CONCA, Raffaele</creator><creator>MAGISTRONI, Paola</creator><creator>FASANO, Maria Edvige</creator><creator>MAZZOLA, Gina</creator><creator>PATANE, Francesco</creator><creator>ZINGARELLI, Edoardo</creator><creator>DALL'OMO, Anna M</creator><creator>BRUSCO, Alfredo</creator><creator>AMOROSO, Antonio</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060427</creationdate><title>Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation</title><author>FRISALDI, Elisa ; CONCA, Raffaele ; MAGISTRONI, Paola ; FASANO, Maria Edvige ; MAZZOLA, Gina ; PATANE, Francesco ; ZINGARELLI, Edoardo ; DALL'OMO, Anna M ; BRUSCO, Alfredo ; AMOROSO, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-3855aa65e40c09461ec90f92e40f55211d089bc474521d1beb0152c1925310773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Heart Transplantation - mortality</topic><topic>Humans</topic><topic>Ki-1 Antigen - blood</topic><topic>Ki-1 Antigen - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Prognosis</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRISALDI, Elisa</creatorcontrib><creatorcontrib>CONCA, Raffaele</creatorcontrib><creatorcontrib>MAGISTRONI, Paola</creatorcontrib><creatorcontrib>FASANO, Maria Edvige</creatorcontrib><creatorcontrib>MAZZOLA, Gina</creatorcontrib><creatorcontrib>PATANE, Francesco</creatorcontrib><creatorcontrib>ZINGARELLI, Edoardo</creatorcontrib><creatorcontrib>DALL'OMO, Anna M</creatorcontrib><creatorcontrib>BRUSCO, Alfredo</creatorcontrib><creatorcontrib>AMOROSO, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRISALDI, Elisa</au><au>CONCA, Raffaele</au><au>MAGISTRONI, Paola</au><au>FASANO, Maria Edvige</au><au>MAZZOLA, Gina</au><au>PATANE, Francesco</au><au>ZINGARELLI, Edoardo</au><au>DALL'OMO, Anna M</au><au>BRUSCO, Alfredo</au><au>AMOROSO, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2006-04-27</date><risdate>2006</risdate><volume>81</volume><issue>8</issue><spage>1153</spage><epage>1156</epage><pages>1153-1156</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT)n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30<or=30 U/ml displayed a significantly better survival. In conclusion, sCD30 levels are predictive of HT outcome.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>16641601</pmid><doi>10.1097/01.tp.0000205181.31604.09</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Heart Transplantation - mortality Humans Ki-1 Antigen - blood Ki-1 Antigen - genetics Male Medical sciences Microsatellite Repeats Middle Aged Polymorphism, Genetic Prognosis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology |
| title | Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation |
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