Epidemiology of severe sepsis in intensive care units in the Slovak Republic
We investigated the number, clinical characteristics, and outcomes of ICU patients, who met precise clinical and physiological criteria for severe sepsis (as defined in the PROWESS study) in Slovak intensive care units. We designed an observational cohort epidemiological study with retrospective ana...
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| Veröffentlicht in: | Infection 2005-06, Vol.33 (3), p.122-128 |
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| creator | Záhorec, R Firment, J Straková, J Mikula, J Malík, P Novák, I Zeman, J Chlebo, P |
| description | We investigated the number, clinical characteristics, and outcomes of ICU patients, who met precise clinical and physiological criteria for severe sepsis (as defined in the PROWESS study) in Slovak intensive care units. We designed an observational cohort epidemiological study with retrospective analysis of prospectively collected data. 12 adult general intensive care units participated in the Slovak Republic between July and December 2002.
Patients included 1,533 adult ICU admissions during the second half of 2002 in 12 adult ICUs. Descriptive statistical methods (independent sample T-test, chi(2) test, and linear Pearson coefficient of correlation) were used.
We found that 7.9% of hospitalized critically ill patients met severe sepsis criteria in the intensive care units. The most frequent primary sources of infection were lungs and abdomen. Hospital mortality of severe septic patients was 51.2% (62 pts/121 pts). Most patients (85.1%) were > 40 years of age. Mortality increased with age; mean average age of survivors (53 years) was significantly lower than in nonsurvivors (61 years, p = 0.01). Factors associated with mortality were age over 50 years, three or more dysfunctional organs, and elevated admission and maximum SOFA scores. Survivors had a significantly lower number of sites with organ system dysfunction (MODS 2.56) than nonsurvivors (MODS 3.98). SOFA score seems to be a valuable tool to differentiate survivors from nonsurvivors. All the septic patients had SOFA scores greater than 4 points. Survivors of severe sepsis were characterized with significantly lower admission and maximum SOFA scores (median 8.7 and 9.4 points, respectively) than septic nonsurvivors (median 11.6 and 14.0 points, respectively, p = 0.001).
We estimate 1,770 cases of severe sepsis hospitalized at Slovak adult intensive care units per year. Hospital mortality for severe sepsis remains very high (51.2%) and is associated with advanced age (over 50 years), number of failing organs and higher admission and maximum SOFA scores. |
| doi_str_mv | 10.1007/s15010-005-4019-2 |
| format | Article |
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Patients included 1,533 adult ICU admissions during the second half of 2002 in 12 adult ICUs. Descriptive statistical methods (independent sample T-test, chi(2) test, and linear Pearson coefficient of correlation) were used.
We found that 7.9% of hospitalized critically ill patients met severe sepsis criteria in the intensive care units. The most frequent primary sources of infection were lungs and abdomen. Hospital mortality of severe septic patients was 51.2% (62 pts/121 pts). Most patients (85.1%) were > 40 years of age. Mortality increased with age; mean average age of survivors (53 years) was significantly lower than in nonsurvivors (61 years, p = 0.01). Factors associated with mortality were age over 50 years, three or more dysfunctional organs, and elevated admission and maximum SOFA scores. Survivors had a significantly lower number of sites with organ system dysfunction (MODS 2.56) than nonsurvivors (MODS 3.98). SOFA score seems to be a valuable tool to differentiate survivors from nonsurvivors. All the septic patients had SOFA scores greater than 4 points. Survivors of severe sepsis were characterized with significantly lower admission and maximum SOFA scores (median 8.7 and 9.4 points, respectively) than septic nonsurvivors (median 11.6 and 14.0 points, respectively, p = 0.001).
We estimate 1,770 cases of severe sepsis hospitalized at Slovak adult intensive care units per year. Hospital mortality for severe sepsis remains very high (51.2%) and is associated with advanced age (over 50 years), number of failing organs and higher admission and maximum SOFA scores.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-005-4019-2</identifier><identifier>PMID: 15940412</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Community-Acquired Infections - epidemiology ; Cross Infection - epidemiology ; Epidemiology ; Female ; Hospitals ; Humans ; Intensive Care Units - standards ; Longitudinal Studies ; Male ; Middle Aged ; Mortality ; Prospective Studies ; Sepsis - epidemiology ; Shock, Septic - epidemiology ; Slovakia - epidemiology ; Statistical methods</subject><ispartof>Infection, 2005-06, Vol.33 (3), p.122-128</ispartof><rights>Urban & Vogel Medien und Medizin Verlagsgesellschaft 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-a9cf7f6daa0dd01dbfec79d09641152de6d0880463565cac7031ea18111b21b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15940412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Záhorec, R</creatorcontrib><creatorcontrib>Firment, J</creatorcontrib><creatorcontrib>Straková, J</creatorcontrib><creatorcontrib>Mikula, J</creatorcontrib><creatorcontrib>Malík, P</creatorcontrib><creatorcontrib>Novák, I</creatorcontrib><creatorcontrib>Zeman, J</creatorcontrib><creatorcontrib>Chlebo, P</creatorcontrib><title>Epidemiology of severe sepsis in intensive care units in the Slovak Republic</title><title>Infection</title><addtitle>Infection</addtitle><description>We investigated the number, clinical characteristics, and outcomes of ICU patients, who met precise clinical and physiological criteria for severe sepsis (as defined in the PROWESS study) in Slovak intensive care units. We designed an observational cohort epidemiological study with retrospective analysis of prospectively collected data. 12 adult general intensive care units participated in the Slovak Republic between July and December 2002.
Patients included 1,533 adult ICU admissions during the second half of 2002 in 12 adult ICUs. Descriptive statistical methods (independent sample T-test, chi(2) test, and linear Pearson coefficient of correlation) were used.
We found that 7.9% of hospitalized critically ill patients met severe sepsis criteria in the intensive care units. The most frequent primary sources of infection were lungs and abdomen. Hospital mortality of severe septic patients was 51.2% (62 pts/121 pts). Most patients (85.1%) were > 40 years of age. Mortality increased with age; mean average age of survivors (53 years) was significantly lower than in nonsurvivors (61 years, p = 0.01). Factors associated with mortality were age over 50 years, three or more dysfunctional organs, and elevated admission and maximum SOFA scores. Survivors had a significantly lower number of sites with organ system dysfunction (MODS 2.56) than nonsurvivors (MODS 3.98). SOFA score seems to be a valuable tool to differentiate survivors from nonsurvivors. All the septic patients had SOFA scores greater than 4 points. Survivors of severe sepsis were characterized with significantly lower admission and maximum SOFA scores (median 8.7 and 9.4 points, respectively) than septic nonsurvivors (median 11.6 and 14.0 points, respectively, p = 0.001).
We estimate 1,770 cases of severe sepsis hospitalized at Slovak adult intensive care units per year. Hospital mortality for severe sepsis remains very high (51.2%) and is associated with advanced age (over 50 years), number of failing organs and higher admission and maximum SOFA scores.</description><subject>Adult</subject><subject>Aged</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Cross Infection - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive Care Units - standards</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Prospective Studies</subject><subject>Sepsis - epidemiology</subject><subject>Shock, Septic - epidemiology</subject><subject>Slovakia - epidemiology</subject><subject>Statistical methods</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkdFL5DAQxoN46Lp3f4AvUnzwrXczTZM0jyJ6JywIuu8hTaYa7ba1aRf8743uguDLwcAHM79vYOZj7BThNwKoPxEFIOQAIi8BdV4csAWWXOegFT9kC-AAeYWFPGYnMT5DAnWpjtgxJoUSiwVbXQ_B0yb0bf_4lvVNFmlLIyUZYohZ6FJN1MWwpczZNJi7MH32pyfKHtp-a1-yexrmug3uJ_vR2DbSr70u2frmen31L1_d_b29ulzljgs15Va7RjXSWwveA_q6Iae0By1LRFF4kh6qCkrJhRTOOgUcyWKFiHWBNV-yi93aYexfZ4qT2YToqG1tR_0cjVQaZIXivyAqAVpwmcDzb-BzP49dusEUKCRWVVEmCHeQG_sYR2rMMIaNHd8MgvnIw-zyMOnN5iMPUyTP2X7xXG_Ifzn2AfB3cGWExg</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Záhorec, R</creator><creator>Firment, J</creator><creator>Straková, J</creator><creator>Mikula, J</creator><creator>Malík, P</creator><creator>Novák, I</creator><creator>Zeman, J</creator><creator>Chlebo, P</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Epidemiology of severe sepsis in intensive care units in the Slovak Republic</title><author>Záhorec, R ; Firment, J ; Straková, J ; Mikula, J ; Malík, P ; Novák, I ; Zeman, J ; Chlebo, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-a9cf7f6daa0dd01dbfec79d09641152de6d0880463565cac7031ea18111b21b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Cross Infection - epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intensive Care Units - standards</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Prospective Studies</topic><topic>Sepsis - epidemiology</topic><topic>Shock, Septic - epidemiology</topic><topic>Slovakia - epidemiology</topic><topic>Statistical methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Záhorec, R</creatorcontrib><creatorcontrib>Firment, J</creatorcontrib><creatorcontrib>Straková, J</creatorcontrib><creatorcontrib>Mikula, J</creatorcontrib><creatorcontrib>Malík, P</creatorcontrib><creatorcontrib>Novák, I</creatorcontrib><creatorcontrib>Zeman, J</creatorcontrib><creatorcontrib>Chlebo, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Záhorec, R</au><au>Firment, J</au><au>Straková, J</au><au>Mikula, J</au><au>Malík, P</au><au>Novák, I</au><au>Zeman, J</au><au>Chlebo, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of severe sepsis in intensive care units in the Slovak Republic</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>2005-06</date><risdate>2005</risdate><volume>33</volume><issue>3</issue><spage>122</spage><epage>128</epage><pages>122-128</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>We investigated the number, clinical characteristics, and outcomes of ICU patients, who met precise clinical and physiological criteria for severe sepsis (as defined in the PROWESS study) in Slovak intensive care units. We designed an observational cohort epidemiological study with retrospective analysis of prospectively collected data. 12 adult general intensive care units participated in the Slovak Republic between July and December 2002.
Patients included 1,533 adult ICU admissions during the second half of 2002 in 12 adult ICUs. Descriptive statistical methods (independent sample T-test, chi(2) test, and linear Pearson coefficient of correlation) were used.
We found that 7.9% of hospitalized critically ill patients met severe sepsis criteria in the intensive care units. The most frequent primary sources of infection were lungs and abdomen. Hospital mortality of severe septic patients was 51.2% (62 pts/121 pts). Most patients (85.1%) were > 40 years of age. Mortality increased with age; mean average age of survivors (53 years) was significantly lower than in nonsurvivors (61 years, p = 0.01). Factors associated with mortality were age over 50 years, three or more dysfunctional organs, and elevated admission and maximum SOFA scores. Survivors had a significantly lower number of sites with organ system dysfunction (MODS 2.56) than nonsurvivors (MODS 3.98). SOFA score seems to be a valuable tool to differentiate survivors from nonsurvivors. All the septic patients had SOFA scores greater than 4 points. Survivors of severe sepsis were characterized with significantly lower admission and maximum SOFA scores (median 8.7 and 9.4 points, respectively) than septic nonsurvivors (median 11.6 and 14.0 points, respectively, p = 0.001).
We estimate 1,770 cases of severe sepsis hospitalized at Slovak adult intensive care units per year. Hospital mortality for severe sepsis remains very high (51.2%) and is associated with advanced age (over 50 years), number of failing organs and higher admission and maximum SOFA scores.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15940412</pmid><doi>10.1007/s15010-005-4019-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Community-Acquired Infections - epidemiology Cross Infection - epidemiology Epidemiology Female Hospitals Humans Intensive Care Units - standards Longitudinal Studies Male Middle Aged Mortality Prospective Studies Sepsis - epidemiology Shock, Septic - epidemiology Slovakia - epidemiology Statistical methods |
| title | Epidemiology of severe sepsis in intensive care units in the Slovak Republic |
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