Effects of imatinib mesylate (Glivec®) as a c-kit tyrosine kinase inhibitor in the guinea-pig urinary bladder

Aims In the gastrointestinal tract, slow wave activity in smooth muscle is generated by the interstitial cells of Cajal (ICC). Detrusor smooth muscle strips of most species show spontaneous contractions which are triggered by action potential bursts, however, the pacemaker mechanisms for the detruso...

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Veröffentlicht in:	Neurourology and urodynamics 2006, Vol.25 (3), p.205-210
Hauptverfasser:	Kubota, Yasue, Biers, Suzanne M., Kohri, Kenjiro, Brading, Alison F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides bladder c-kit Guinea Pigs Imatinib Mesylate imatinib mesylate (Glivec) In Vitro Techniques Male Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-kit Pyrimidines - pharmacology smooth muscle Urinary Bladder - drug effects
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