Rotavirus double-stranded RNA induces apoptosis and diminishes wound repair in rat intestinal epithelial cells

Background: Recent studies have shown that toll‐like receptor 3 (TLR3) recognizes double‐stranded RNA (dsRNA). Rotaviruses, having a dsRNA genome, infect intestinal epithelial cells (IEC) and cause acute gastroenteritis in young children. The aim of the present study was to clarify the pathophysiol...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2006-03, Vol.21 (3), p.521-530
Hauptverfasser:	SATO, AKIKO, IIZUKA, MASAHIRO, NAKAGOMI, OSAMU, SUZUKI, MANABU, HORIE, YASUO, KONNO, SHIHO, HIRASAWA, FUJIKO, SASAKI, KENJI, SHINDO, KENICHI, WATANABE, SUMIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Blotting, Western Cell Line Cell Movement - drug effects Chi-Square Distribution dsRNA Epithelial Cells - cytology Epithelial Cells - drug effects Gastroenterology. Liver. Pancreas. Abdomen Immunohistochemistry Interferon-gamma - pharmacology intestinal epithelial cells Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Medical sciences Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Double-Stranded - physiology Rotavirus Statistics, Nonparametric TLR3 toll-like receptor Toll-Like Receptor 3 - physiology Up-Regulation Wound Healing - drug effects Wound Healing - physiology
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