Targeting C-reactive protein for the treatment of cardiovascular disease

Aiming for the heart C-reactive protein (CRP) is a clinical marker for inflammatory disease and infection, but it also binds to damaged cells and activates complement, a host defence and pro-inflammatory system of serum proteins. Complement-mediated inflammation exacerbates tissue injury in heart at...

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Veröffentlicht in:	Nature 2006-04, Vol.440 (7088), p.1217-1221
Hauptverfasser:	Pepys, Mark B., Hirschfield, Gideon M., Tennent, Glenys A., Ruth Gallimore, J., Kahan, Melvyn C., Bellotti, Vittorio, Hawkins, Philip N., Myers, Rebecca M., Smith, Martin D., Polara, Alessandra, Cobb, Alexander J. A., Ley, Steven V., Andrew Aquilina, J., Robinson, Carol V., Sharif, Isam, Gray, Gillian A., Sabin, Caroline A., Jenvey, Michelle C., Kolstoe, Simon E., Thompson, Darren, Wood, Stephen P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences C-Reactive Protein - antagonists & inhibitors C-Reactive Protein - chemistry C-Reactive Protein - metabolism C-Reactive Protein - pharmacology Cardiology. Vascular system Cardiovascular diseases Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Cardiovascular system Complement System Proteins - immunology Coronary heart disease Developed countries Drug Design Gene therapy Heart Heart attacks Hexanes - administration & dosage Hexanes - chemistry Hexanes - pharmacology Hexanes - therapeutic use Humanities and Social Sciences Humans Inflammatory diseases Inhibitor drugs Injection letter Male Medical sciences Miscellaneous Models, Molecular Molecular Conformation Morbidity Mortality multidisciplinary Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Pharmacology. Drug treatments Phosphorylcholine - administration & dosage Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemistry Phosphorylcholine - pharmacology Phosphorylcholine - therapeutic use Proteins Rats Rats, Wistar Science Science (multidisciplinary) Stroke Tissues
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