Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399Ile are hypo-responsive to Porphyromonas gingivalis

The Toll-like receptor (TLR)4 is the major sensor for bacterial lipopolysaccharide and its two common co-segregating polymorphisms, Asp299Gly and Thr399Ile, which occur at a frequency of between 6 and 10%, have been associated with infectious diseases, LPS hypo-responsiveness and cardiovascular dise...

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Veröffentlicht in:	Genes and immunity 2006-04, Vol.7 (3), p.190-200
Hauptverfasser:	Kinane, D F, Shiba, H, Stathopoulou, P G, Zhao, H, Lappin, D F, Singh, A, Eskan, M A, Beckers, S, Waigel, S, Alpert, B, Knudsen, T B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Aspartic Acid - chemistry Aspartic Acid - genetics Bacteria Biomedical and Life Sciences Biomedicine Cancer Research Cardiovascular diseases Care and treatment Cell culture Cell receptors Cells, Cultured Chemokines Cytokines Dentistry DNA microarrays Epithelial cells Gene Expression Gene Expression Profiling Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotype & phenotype Gingiva Gingiva - immunology Glycine - chemistry Glycine - genetics Gram-negative bacteria Gum disease Heterozygote Human Genetics Humans Immunology Infectious diseases Inflammation Isoleucine - chemistry Isoleucine - genetics Lipopolysaccharides original-article Periodontal disease Periodontitis Phenotypes Physiological aspects Polymorphism Polymorphism, Genetic Porphyromonas gingivalis Porphyromonas gingivalis - immunology Proteins Risk factors Threonine - chemistry Threonine - genetics TLR2 protein TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Toll-Like Receptors - genetics Transcriptomes Tumor necrosis factor-α
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