Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations

Cryopreserved human hepatocytes have been used to predict hepatic in‐vivo clearance. Physiologically‐based direct scaling methods generally underestimate human in‐vivo hepatic clearance. Cryopreserved human hepatocytes were incubated in 100% serum and in serum‐free medium to predict the in‐vivo hepa...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2006-05, Vol.58 (5), p.633-641
Hauptverfasser:	Blanchard, Nadège, Hewitt, Nicola J., Silber, Paul, Jones, Hannah, Coassolo, Philippe, Lave, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipyrine - metabolism Cell Culture Techniques Cryopreservation Hepatocytes - metabolism Humans Kinetics Metabolic Clearance Rate Models, Biological Monte Carlo Method Oxazepam - metabolism Pharmaceutical Preparations - metabolism Protein Binding Reproducibility of Results Serum - metabolism Sulfonamides - metabolism
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