Roles of Nitric Oxide Synthase Inhibition and Vascular Endothelial Growth Factor Receptor-2 Inhibition on Vascular Morphology and Function in an In vivo Model of Pancreatic Cancer

Purpose: Both nitric oxide (NO) and vascular endothelial growth factor (VEGF) mediate tumor vascular function. Because these molecules regulate one another's expression, we hypothesized that NO synthase (NOS) inhibition produces effects comparable to those of anti-VEGF therapy on human pancreat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2006-04, Vol.12 (8), p.2628-2633
Hauptverfasser:	RAMSAY CAMP, E, YANG, Anthony, WENBIAO LIU, FAN FAN, SOMCIO, Ray, HICKLIN, Daniel J, ELLIS, Lee M
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Blood Vessels - chemistry Blood Vessels - drug effects Blood Vessels - pathology Cell Line, Tumor Cell Proliferation - drug effects Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, Nude Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control nitric oxide Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitroarginine - pharmacology Nitroarginine - therapeutic use pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - pathology Pancreatic Neoplasms - prevention & control perfusion Pharmacology. Drug treatments Platelet Endothelial Cell Adhesion Molecule-1 - analysis Random Allocation Tumors vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - immunology Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!