N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring
Objective: We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring. Design: Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabet...
Gespeichert in:
| Veröffentlicht in: | International Journal of Obesity 2006-05, Vol.30 (5), p.739-750 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 750 |
|---|---|
| container_issue | 5 |
| container_start_page | 739 |
| container_title | International Journal of Obesity |
| container_volume | 30 |
| creator | Yessoufou, A Soulaimann, N Merzouk, S A Moutairou, K Ahissou, H Prost, J Simonin, A M Merzouk, H Hichami, A Khan, N A |
| description | Objective:
We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring.
Design:
Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days.
Measurements:
Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitamin A, E and C concentrations, and (iii) antioxidant enzymes activities in erythrocytes. The plasma lipid concentrations and fatty acid composition were also determined.
Results:
Diabetes increased plasma triglyceride and cholesterol concentrations, whereas macrosomia was associated with enhanced plasma cholesterol and triglyceride levels, which diminished by feeding n-3 PUFA diet. N-3 PUFA diet also reduced increased plasma TBARS and corrected the decreased ORAC values in diabetic rats and their macrosomic offspring. EPAX diet increased the diminished vitamin A levels in diabetic mothers and vitamin C concentrations in macrosomic pups. Also, this diet improved the decreased erythrocyte superoxide dismutase and glutathione peroxidase activities in diabetic and macrosomic animals.
Conclusion:
Diabetes and macrosomia were associated with altered lipid metabolism, antioxidant enzyme activities and vitamin concentrations. N-3 PUFA diet improved hyperlipidemia and restored antioxidant status in diabetic dams and MAC offspring. |
| doi_str_mv | 10.1038/sj.ijo.0803211 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67904664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188437886</galeid><sourcerecordid>A188437886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-ec21de736f59d22425c1ee93cdd3d82bc233b3403a3d0c5b8041cfdd90641d3d3</originalsourceid><addsrcrecordid>eNp1kc9rFDEUx4Modq1ePUpQ7G22-TmTHEuxKhS96MlDyCSZbpaZSc3LgP3vzbIDq1LJ4UHyed-X9_0i9JqSLSVcXcJ-G_dpSxThjNInaENF1zZS6O4p2hBOuobIVp6hFwB7QoiUhD1HZ7QVVHVSb9CPLw3HN7aUB2xd9ICn5JfRloDtXGL6FX2tGIotC-A4Yx9tH0p0ONsClfG47ELMeLIuJ0hTfUnDAPc5zncv0bPBjhBerfUcfb_58O36U3P79ePn66vbxkmmShMcoz50vB2k9owJJh0NQXPnPfeK9Y5x3nNBuOWeONkrIqgbvNekblERfo4ujrr3Of1cAhQzRXBhHO0c0gKm7TQRbSsq-PYfcJ-WPNe_GUY101xoXaF3R-jOjsHEeUglW3dQNFdUKcE7pdpKbR-h6vGhepDmMMR6_1fDxR8Nu2DHsoM0LtXkGR5VPhgKOQymmjnZ_GAoMYfMDexNzdysmdeGN-tWSz8Ff8LXkCvwfgUsODsO2c4uwonrWs0oOQhdHrljfCGf7PnP6N-Kp8Kj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219293499</pqid></control><display><type>article</type><title>N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Journals Online</source><creator>Yessoufou, A ; Soulaimann, N ; Merzouk, S A ; Moutairou, K ; Ahissou, H ; Prost, J ; Simonin, A M ; Merzouk, H ; Hichami, A ; Khan, N A</creator><creatorcontrib>Yessoufou, A ; Soulaimann, N ; Merzouk, S A ; Moutairou, K ; Ahissou, H ; Prost, J ; Simonin, A M ; Merzouk, H ; Hichami, A ; Khan, N A</creatorcontrib><description>Objective:
We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring.
Design:
Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days.
Measurements:
Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitamin A, E and C concentrations, and (iii) antioxidant enzymes activities in erythrocytes. The plasma lipid concentrations and fatty acid composition were also determined.
Results:
Diabetes increased plasma triglyceride and cholesterol concentrations, whereas macrosomia was associated with enhanced plasma cholesterol and triglyceride levels, which diminished by feeding n-3 PUFA diet. N-3 PUFA diet also reduced increased plasma TBARS and corrected the decreased ORAC values in diabetic rats and their macrosomic offspring. EPAX diet increased the diminished vitamin A levels in diabetic mothers and vitamin C concentrations in macrosomic pups. Also, this diet improved the decreased erythrocyte superoxide dismutase and glutathione peroxidase activities in diabetic and macrosomic animals.
Conclusion:
Diabetes and macrosomia were associated with altered lipid metabolism, antioxidant enzyme activities and vitamin concentrations. N-3 PUFA diet improved hyperlipidemia and restored antioxidant status in diabetic dams and MAC offspring.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803211</identifier><identifier>PMID: 16418759</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Animals, Newborn ; Antioxidants ; Antioxidants - metabolism ; Ascorbic Acid - blood ; Biological and medical sciences ; Biomarkers - blood ; Cholesterol ; Diabetes ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - embryology ; Diabetes Mellitus - metabolism ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - embryology ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - embryology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Diet ; Diseases of mother, fetus and pregnancy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymatic activity ; Enzymes ; Epidemiology ; Erythrocytes ; Erythrocytes - enzymology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Fatty Acids - blood ; Fatty Acids, Omega-3 - administration & dosage ; Female ; Fetal Macrosomia - metabolism ; Free Radical Scavengers - metabolism ; Glutathione Peroxidase - blood ; Gynecology. Andrology. Obstetrics ; Health Promotion and Disease Prevention ; Internal Medicine ; Lipid Peroxidation ; Lipids ; Lipids - blood ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Obesity ; Offspring ; original-article ; Oxidative stress ; Peroxidation ; Physiology ; Plasma ; Polyunsaturated fatty acids ; Pregnancy ; Pregnancy in Diabetics - drug therapy ; Pregnancy in Diabetics - metabolism ; Pregnancy. Fetus. Placenta ; Public Health ; Rats ; Rats, Wistar ; Superoxide Dismutase - blood ; Thiobarbituric Acid Reactive Substances - analysis ; Vegetable oils ; Vitamin A - blood ; Vitamin E - blood</subject><ispartof>International Journal of Obesity, 2006-05, Vol.30 (5), p.739-750</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-ec21de736f59d22425c1ee93cdd3d82bc233b3403a3d0c5b8041cfdd90641d3d3</citedby><cites>FETCH-LOGICAL-c528t-ec21de736f59d22425c1ee93cdd3d82bc233b3403a3d0c5b8041cfdd90641d3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0803211$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0803211$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17692101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16418759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yessoufou, A</creatorcontrib><creatorcontrib>Soulaimann, N</creatorcontrib><creatorcontrib>Merzouk, S A</creatorcontrib><creatorcontrib>Moutairou, K</creatorcontrib><creatorcontrib>Ahissou, H</creatorcontrib><creatorcontrib>Prost, J</creatorcontrib><creatorcontrib>Simonin, A M</creatorcontrib><creatorcontrib>Merzouk, H</creatorcontrib><creatorcontrib>Hichami, A</creatorcontrib><creatorcontrib>Khan, N A</creatorcontrib><title>N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective:
We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring.
Design:
Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days.
Measurements:
Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitamin A, E and C concentrations, and (iii) antioxidant enzymes activities in erythrocytes. The plasma lipid concentrations and fatty acid composition were also determined.
Results:
Diabetes increased plasma triglyceride and cholesterol concentrations, whereas macrosomia was associated with enhanced plasma cholesterol and triglyceride levels, which diminished by feeding n-3 PUFA diet. N-3 PUFA diet also reduced increased plasma TBARS and corrected the decreased ORAC values in diabetic rats and their macrosomic offspring. EPAX diet increased the diminished vitamin A levels in diabetic mothers and vitamin C concentrations in macrosomic pups. Also, this diet improved the decreased erythrocyte superoxide dismutase and glutathione peroxidase activities in diabetic and macrosomic animals.
Conclusion:
Diabetes and macrosomia were associated with altered lipid metabolism, antioxidant enzyme activities and vitamin concentrations. N-3 PUFA diet improved hyperlipidemia and restored antioxidant status in diabetic dams and MAC offspring.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic Acid - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - embryology</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - embryology</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - embryology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzymatic activity</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Erythrocytes</subject><subject>Erythrocytes - enzymology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty acids</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Female</subject><subject>Fetal Macrosomia - metabolism</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Glutathione Peroxidase - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health Promotion and Disease Prevention</subject><subject>Internal Medicine</subject><subject>Lipid Peroxidation</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Offspring</subject><subject>original-article</subject><subject>Oxidative stress</subject><subject>Peroxidation</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Polyunsaturated fatty acids</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - drug therapy</subject><subject>Pregnancy in Diabetics - metabolism</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Public Health</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - blood</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Vegetable oils</subject><subject>Vitamin A - blood</subject><subject>Vitamin E - blood</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9rFDEUx4Modq1ePUpQ7G22-TmTHEuxKhS96MlDyCSZbpaZSc3LgP3vzbIDq1LJ4UHyed-X9_0i9JqSLSVcXcJ-G_dpSxThjNInaENF1zZS6O4p2hBOuobIVp6hFwB7QoiUhD1HZ7QVVHVSb9CPLw3HN7aUB2xd9ICn5JfRloDtXGL6FX2tGIotC-A4Yx9tH0p0ONsClfG47ELMeLIuJ0hTfUnDAPc5zncv0bPBjhBerfUcfb_58O36U3P79ePn66vbxkmmShMcoz50vB2k9owJJh0NQXPnPfeK9Y5x3nNBuOWeONkrIqgbvNekblERfo4ujrr3Of1cAhQzRXBhHO0c0gKm7TQRbSsq-PYfcJ-WPNe_GUY101xoXaF3R-jOjsHEeUglW3dQNFdUKcE7pdpKbR-h6vGhepDmMMR6_1fDxR8Nu2DHsoM0LtXkGR5VPhgKOQymmjnZ_GAoMYfMDexNzdysmdeGN-tWSz8Ff8LXkCvwfgUsODsO2c4uwonrWs0oOQhdHrljfCGf7PnP6N-Kp8Kj</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Yessoufou, A</creator><creator>Soulaimann, N</creator><creator>Merzouk, S A</creator><creator>Moutairou, K</creator><creator>Ahissou, H</creator><creator>Prost, J</creator><creator>Simonin, A M</creator><creator>Merzouk, H</creator><creator>Hichami, A</creator><creator>Khan, N A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring</title><author>Yessoufou, A ; Soulaimann, N ; Merzouk, S A ; Moutairou, K ; Ahissou, H ; Prost, J ; Simonin, A M ; Merzouk, H ; Hichami, A ; Khan, N A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-ec21de736f59d22425c1ee93cdd3d82bc233b3403a3d0c5b8041cfdd90641d3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Ascorbic Acid - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - embryology</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - embryology</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - embryology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzymatic activity</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Erythrocytes</topic><topic>Erythrocytes - enzymology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty acids</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Female</topic><topic>Fetal Macrosomia - metabolism</topic><topic>Free Radical Scavengers - metabolism</topic><topic>Glutathione Peroxidase - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health Promotion and Disease Prevention</topic><topic>Internal Medicine</topic><topic>Lipid Peroxidation</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Offspring</topic><topic>original-article</topic><topic>Oxidative stress</topic><topic>Peroxidation</topic><topic>Physiology</topic><topic>Plasma</topic><topic>Polyunsaturated fatty acids</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - drug therapy</topic><topic>Pregnancy in Diabetics - metabolism</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Public Health</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - blood</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>Vegetable oils</topic><topic>Vitamin A - blood</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yessoufou, A</creatorcontrib><creatorcontrib>Soulaimann, N</creatorcontrib><creatorcontrib>Merzouk, S A</creatorcontrib><creatorcontrib>Moutairou, K</creatorcontrib><creatorcontrib>Ahissou, H</creatorcontrib><creatorcontrib>Prost, J</creatorcontrib><creatorcontrib>Simonin, A M</creatorcontrib><creatorcontrib>Merzouk, H</creatorcontrib><creatorcontrib>Hichami, A</creatorcontrib><creatorcontrib>Khan, N A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yessoufou, A</au><au>Soulaimann, N</au><au>Merzouk, S A</au><au>Moutairou, K</au><au>Ahissou, H</au><au>Prost, J</au><au>Simonin, A M</au><au>Merzouk, H</au><au>Hichami, A</au><au>Khan, N A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>30</volume><issue>5</issue><spage>739</spage><epage>750</epage><pages>739-750</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Objective:
We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring.
Design:
Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days.
Measurements:
Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitamin A, E and C concentrations, and (iii) antioxidant enzymes activities in erythrocytes. The plasma lipid concentrations and fatty acid composition were also determined.
Results:
Diabetes increased plasma triglyceride and cholesterol concentrations, whereas macrosomia was associated with enhanced plasma cholesterol and triglyceride levels, which diminished by feeding n-3 PUFA diet. N-3 PUFA diet also reduced increased plasma TBARS and corrected the decreased ORAC values in diabetic rats and their macrosomic offspring. EPAX diet increased the diminished vitamin A levels in diabetic mothers and vitamin C concentrations in macrosomic pups. Also, this diet improved the decreased erythrocyte superoxide dismutase and glutathione peroxidase activities in diabetic and macrosomic animals.
Conclusion:
Diabetes and macrosomia were associated with altered lipid metabolism, antioxidant enzyme activities and vitamin concentrations. N-3 PUFA diet improved hyperlipidemia and restored antioxidant status in diabetic dams and MAC offspring.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16418759</pmid><doi>10.1038/sj.ijo.0803211</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2006-05, Vol.30 (5), p.739-750 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67904664 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online |
| subjects | Animals Animals, Newborn Antioxidants Antioxidants - metabolism Ascorbic Acid - blood Biological and medical sciences Biomarkers - blood Cholesterol Diabetes Diabetes Mellitus - drug therapy Diabetes Mellitus - embryology Diabetes Mellitus - metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - embryology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - embryology Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diet Diseases of mother, fetus and pregnancy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymatic activity Enzymes Epidemiology Erythrocytes Erythrocytes - enzymology Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty Acids - blood Fatty Acids, Omega-3 - administration & dosage Female Fetal Macrosomia - metabolism Free Radical Scavengers - metabolism Glutathione Peroxidase - blood Gynecology. Andrology. Obstetrics Health Promotion and Disease Prevention Internal Medicine Lipid Peroxidation Lipids Lipids - blood Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Obesity Offspring original-article Oxidative stress Peroxidation Physiology Plasma Polyunsaturated fatty acids Pregnancy Pregnancy in Diabetics - drug therapy Pregnancy in Diabetics - metabolism Pregnancy. Fetus. Placenta Public Health Rats Rats, Wistar Superoxide Dismutase - blood Thiobarbituric Acid Reactive Substances - analysis Vegetable oils Vitamin A - blood Vitamin E - blood |
| title | N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T11%3A47%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=N-3%20Fatty%20acids%20modulate%20antioxidant%20status%20in%20diabetic%20rats%20and%20their%20macrosomic%20offspring&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Yessoufou,%20A&rft.date=2006-05-01&rft.volume=30&rft.issue=5&rft.spage=739&rft.epage=750&rft.pages=739-750&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/sj.ijo.0803211&rft_dat=%3Cgale_proqu%3EA188437886%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219293499&rft_id=info:pmid/16418759&rft_galeid=A188437886&rfr_iscdi=true |