Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Hepcidin is a key regulator of systemic iron homeostasis. Hepcidin deficiency induces iron overload, whereas hepcidin excess induces anemia. Mutations in the gene encoding hemojuvelin ( HFE2 , also known as HJV ) cause severe iron overload and correlate with low hepcidin levels, suggesting that hemo...

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Veröffentlicht in:	Nature genetics 2006-05, Vol.38 (5), p.531-539
Hauptverfasser:	Babitt, Jodie L, Huang, Franklin W, Wrighting, Diedra M, Xia, Yin, Sidis, Yisrael, Samad, Tarek A, Campagna, Jason A, Chung, Raymond T, Schneyer, Alan L, Woolf, Clifford J, Andrews, Nancy C, Lin, Herbert Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Antimicrobial Cationic Peptides - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Bone Morphogenetic Protein 2 Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Cancer Research CHO Cells Complications and side effects Cricetinae Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - physiology Gene Function Gene mutations Genetic aspects Genetics of eukaryotes. Biological and molecular evolution GPI-Linked Proteins Hepcidins Human Genetics Humans Iron Liver - cytology Liver - metabolism Membrane Proteins - genetics Membrane Proteins - physiology Molecular Sequence Data Mutation Peptide hormones Polymerase Chain Reaction Proteins Signal transduction Signal Transduction - physiology Transforming Growth Factor beta - metabolism
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