Direct Measurement of Nitric Oxide during Experimental Cardiopulmonary Bypass
We developed a system to measure nitric oxide (NO) concentration during cardiopulmonary bypass in anaesthetized pigs (n = 6). A T-shaped connector, attached to an NO sensor, was mounted in the extra-corporeal circuit at two measuring sites: proximal to the membrane oxygenator (venous side) and dista...
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| Veröffentlicht in: | Journal of international medical research 2005-05, Vol.33 (3), p.295-300 |
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| container_title | Journal of international medical research |
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| creator | Hamanaka, S Tanemoto, K Inagaki, E Yamasawa, T Yoshida, K Mochizuki, S Goto, M Miyasaka, T Kajiya, F Tanaka, N |
| description | We developed a system to measure nitric oxide (NO) concentration during cardiopulmonary bypass in anaesthetized pigs (n = 6). A T-shaped connector, attached to an NO sensor, was mounted in the extra-corporeal circuit at two measuring sites: proximal to the membrane oxygenator (venous side) and distal to the arterial line filter (arterial side). After performing a preliminary validation study, we measured plasma NO concentration before and during total cardiopulmonary bypass circulation (non-pulsatile flow 1.5 l/min) and without pulmonary ventilation. After establishing bypass, PaO2 was 318-393 mmHg; when PaO2 was decreased to 80-100 mmHg, plasma NO concentration in the arterial circuit fell by 39.2 ± 15.6 nM. There was no observable change in plasma NO concentration at the venous circuit. This new system could be useful in monitoring NO concentration during cardiac surgery with cardiopulmonary bypass, and for understanding the possible pathophysiological roles of hyper-nitric oxaemia in cardiopulmonary bypass-related cardiovascular complications. |
| doi_str_mv | 10.1177/147323000503300304 |
| format | Article |
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A T-shaped connector, attached to an NO sensor, was mounted in the extra-corporeal circuit at two measuring sites: proximal to the membrane oxygenator (venous side) and distal to the arterial line filter (arterial side). After performing a preliminary validation study, we measured plasma NO concentration before and during total cardiopulmonary bypass circulation (non-pulsatile flow 1.5 l/min) and without pulmonary ventilation. After establishing bypass, PaO2 was 318-393 mmHg; when PaO2 was decreased to 80-100 mmHg, plasma NO concentration in the arterial circuit fell by 39.2 ± 15.6 nM. There was no observable change in plasma NO concentration at the venous circuit. This new system could be useful in monitoring NO concentration during cardiac surgery with cardiopulmonary bypass, and for understanding the possible pathophysiological roles of hyper-nitric oxaemia in cardiopulmonary bypass-related cardiovascular complications.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/147323000503300304</identifier><identifier>PMID: 15938590</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Cardiac Surgical Procedures - methods ; Cardiopulmonary Bypass - methods ; Disease Models, Animal ; Extracorporeal Circulation ; Extracorporeal Membrane Oxygenation ; Nitric Oxide - analysis ; Nitric Oxide - chemistry ; Nitric Oxide - metabolism ; Oxygen - metabolism ; Oxygenators ; Swine ; Thromboembolism - surgery</subject><ispartof>Journal of international medical research, 2005-05, Vol.33 (3), p.295-300</ispartof><rights>2005 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c336t-cb20982ac5e92d8fd2597d2d668985d0e9ad9177c09e43163cad1e2f679c80b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/147323000503300304$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/147323000503300304$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/147323000503300304?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15938590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamanaka, S</creatorcontrib><creatorcontrib>Tanemoto, K</creatorcontrib><creatorcontrib>Inagaki, E</creatorcontrib><creatorcontrib>Yamasawa, T</creatorcontrib><creatorcontrib>Yoshida, K</creatorcontrib><creatorcontrib>Mochizuki, S</creatorcontrib><creatorcontrib>Goto, M</creatorcontrib><creatorcontrib>Miyasaka, T</creatorcontrib><creatorcontrib>Kajiya, F</creatorcontrib><creatorcontrib>Tanaka, N</creatorcontrib><title>Direct Measurement of Nitric Oxide during Experimental Cardiopulmonary Bypass</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>We developed a system to measure nitric oxide (NO) concentration during cardiopulmonary bypass in anaesthetized pigs (n = 6). A T-shaped connector, attached to an NO sensor, was mounted in the extra-corporeal circuit at two measuring sites: proximal to the membrane oxygenator (venous side) and distal to the arterial line filter (arterial side). After performing a preliminary validation study, we measured plasma NO concentration before and during total cardiopulmonary bypass circulation (non-pulsatile flow 1.5 l/min) and without pulmonary ventilation. After establishing bypass, PaO2 was 318-393 mmHg; when PaO2 was decreased to 80-100 mmHg, plasma NO concentration in the arterial circuit fell by 39.2 ± 15.6 nM. There was no observable change in plasma NO concentration at the venous circuit. This new system could be useful in monitoring NO concentration during cardiac surgery with cardiopulmonary bypass, and for understanding the possible pathophysiological roles of hyper-nitric oxaemia in cardiopulmonary bypass-related cardiovascular complications.</description><subject>Animals</subject><subject>Cardiac Surgical Procedures - methods</subject><subject>Cardiopulmonary Bypass - methods</subject><subject>Disease Models, Animal</subject><subject>Extracorporeal Circulation</subject><subject>Extracorporeal Membrane Oxygenation</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - chemistry</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Oxygenators</subject><subject>Swine</subject><subject>Thromboembolism - surgery</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EoqXwAhyQT9xC13acxEco5Udq6QXOkWtvqlRpEuxEat8eR63EAYnTSqNvRjtDyC2DB8bSdMriVHABABJEOALiMzIexGhQz8k4SBBBAnJErrzfAsQ8kfySjJhUIpMKxmT5XDo0HV2i9r3DHdYdbQr6UXauNHS1Ly1S27uy3tD5vkVXDoSu6Ew7WzZtX-2aWrsDfTq02vtrclHoyuPN6U7I18v8c_YWLVav77PHRWSESLrIrDmojGsjUXGbFZZLlVpukyRTmbSASlsVGhpQGAuWCKMtQ14kqTIZrKWYkPtjbuua7x59l-9Kb7CqdI1N7_MAhq4cAsiPoHGN9w6LvA0VwsM5g3wYMf87YjDdndL79Q7tr-W0WgCmR8DrDebbpnd1aPtf5A_WlXl_</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Hamanaka, S</creator><creator>Tanemoto, K</creator><creator>Inagaki, E</creator><creator>Yamasawa, T</creator><creator>Yoshida, K</creator><creator>Mochizuki, S</creator><creator>Goto, M</creator><creator>Miyasaka, T</creator><creator>Kajiya, F</creator><creator>Tanaka, N</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Direct Measurement of Nitric Oxide during Experimental Cardiopulmonary Bypass</title><author>Hamanaka, S ; Tanemoto, K ; Inagaki, E ; Yamasawa, T ; Yoshida, K ; Mochizuki, S ; Goto, M ; Miyasaka, T ; Kajiya, F ; Tanaka, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-cb20982ac5e92d8fd2597d2d668985d0e9ad9177c09e43163cad1e2f679c80b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Cardiac Surgical Procedures - methods</topic><topic>Cardiopulmonary Bypass - methods</topic><topic>Disease Models, Animal</topic><topic>Extracorporeal Circulation</topic><topic>Extracorporeal Membrane Oxygenation</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - chemistry</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Oxygenators</topic><topic>Swine</topic><topic>Thromboembolism - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamanaka, S</creatorcontrib><creatorcontrib>Tanemoto, K</creatorcontrib><creatorcontrib>Inagaki, E</creatorcontrib><creatorcontrib>Yamasawa, T</creatorcontrib><creatorcontrib>Yoshida, K</creatorcontrib><creatorcontrib>Mochizuki, S</creatorcontrib><creatorcontrib>Goto, M</creatorcontrib><creatorcontrib>Miyasaka, T</creatorcontrib><creatorcontrib>Kajiya, F</creatorcontrib><creatorcontrib>Tanaka, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hamanaka, S</au><au>Tanemoto, K</au><au>Inagaki, E</au><au>Yamasawa, T</au><au>Yoshida, K</au><au>Mochizuki, S</au><au>Goto, M</au><au>Miyasaka, T</au><au>Kajiya, F</au><au>Tanaka, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct Measurement of Nitric Oxide during Experimental Cardiopulmonary Bypass</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>33</volume><issue>3</issue><spage>295</spage><epage>300</epage><pages>295-300</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>We developed a system to measure nitric oxide (NO) concentration during cardiopulmonary bypass in anaesthetized pigs (n = 6). A T-shaped connector, attached to an NO sensor, was mounted in the extra-corporeal circuit at two measuring sites: proximal to the membrane oxygenator (venous side) and distal to the arterial line filter (arterial side). After performing a preliminary validation study, we measured plasma NO concentration before and during total cardiopulmonary bypass circulation (non-pulsatile flow 1.5 l/min) and without pulmonary ventilation. After establishing bypass, PaO2 was 318-393 mmHg; when PaO2 was decreased to 80-100 mmHg, plasma NO concentration in the arterial circuit fell by 39.2 ± 15.6 nM. There was no observable change in plasma NO concentration at the venous circuit. This new system could be useful in monitoring NO concentration during cardiac surgery with cardiopulmonary bypass, and for understanding the possible pathophysiological roles of hyper-nitric oxaemia in cardiopulmonary bypass-related cardiovascular complications.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>15938590</pmid><doi>10.1177/147323000503300304</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cardiac Surgical Procedures - methods Cardiopulmonary Bypass - methods Disease Models, Animal Extracorporeal Circulation Extracorporeal Membrane Oxygenation Nitric Oxide - analysis Nitric Oxide - chemistry Nitric Oxide - metabolism Oxygen - metabolism Oxygenators Swine Thromboembolism - surgery |
| title | Direct Measurement of Nitric Oxide during Experimental Cardiopulmonary Bypass |
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