Tamoxifen alters gating of the BK α subunit and mediates enhanced interactions with the avian β subunit

Mammalian BK channels are modulated by estrogen and non-steroidal estrogen-like compounds (i.e. xenoestrogens), but the effects are dependent on channel composition. (Xeno)estrogens preferentially activate BK channels through accessory β subunits, but reduce single-channel conductance by interaction...

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Veröffentlicht in:	Biochemical pharmacology 2005-07, Vol.70 (1), p.47-58
1. Verfasser:	Duncan, R.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Calcium-activated potassium channel Chicken Chickens Dose-Response Relationship, Drug Estrogen Hormone Humans Ion Channel Gating - drug effects Large-Conductance Calcium-Activated Potassium Channel alpha Subunits Large-Conductance Calcium-Activated Potassium Channel beta Subunits Large-Conductance Calcium-Activated Potassium Channels Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Potassium Channels, Calcium-Activated - chemistry Potassium Channels, Calcium-Activated - drug effects Potassium Channels, Calcium-Activated - physiology Protein Conformation Protein Subunits Tamoxifen - pharmacology Xenoestrogen
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