Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer

Purpose: ARHI expression is lost or markedly down-regulated in the majority of ovarian cancers. The mechanism by which ARHI is down-regulated in ovarian cancers is still not clear. Our previous reports indicated that ARHI promoter activity was reduced in ovarian cancer cells, due in part to the effe...

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Veröffentlicht in:	Clinical cancer research 2006-04, Vol.12 (8), p.2404-2413
Hauptverfasser:	ZHEN LU, LUO, Robert Z, YINHUA YU, BAST, Robert C, HONGQI PENG, ROSEN, Daniel G, NEELY ATKINSON, E, WARNEKE, Carla, MAOSHENG HUANG, NISHMOTO, Arata, JINSONG LIU, LIAR, Warren S-L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents ARHI Base Sequence Binding Sites - genetics Biological and medical sciences Cell Line, Tumor Cells, Cultured Down-Regulation - genetics E2F Transcription Factors - genetics E2F Transcription Factors - metabolism Electrophoretic Mobility Shift Assay Female Female genital diseases Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Genomic Imprinting Gynecology. Andrology. Obstetrics Humans Luciferases - genetics Luciferases - metabolism Medical sciences ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Pharmacology. Drug treatments Promoter Regions, Genetic - genetics Protein Binding Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction rho GTP-Binding Proteins - genetics RNA instability RNA Processing, Post-Transcriptional - genetics RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic - genetics transcriptional regulation tumor suppressor gene Tumors
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