Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center
BACKGROUND: Living‐donor liver transplantation (LDLT) has been an important option in the treatment of patients with end‐stage liver disease. Massive intraoperative blood loss can occur during LDLT, necessitating blood transfusion. The purpose of this study was to present blood loss data from the re...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2005-06, Vol.45 (6), p.879-884 |
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| creator | Yuasa, Takeshi Niwa, Norimi Kimura, Shinya Tsuji, Hiroaki Yurugi, Kimiko Egawa, Hiroto Tanaka, Koichi Asano, Hiroaki Maekawa, Taira |
| description | BACKGROUND: Living‐donor liver transplantation (LDLT) has been an important option in the treatment of patients with end‐stage liver disease. Massive intraoperative blood loss can occur during LDLT, necessitating blood transfusion. The purpose of this study was to present blood loss data from the recipients of LDLT, to assess the effect of massive intraoperative blood loss on prognosis, and to assess the reliability of preoperative information in predicting intraoperative blood transfusion requirements in LDLT.
STUDY DESIGN AND METHODS: A total of 635 patients who underwent LDLTs between January 1995 and March 2002 at a university hospital were retro‐ spectively investigated. The volume of blood loss, prognosis, and preoperative variables were analyzed statistically.
RESULTS: Intraoperative blood loss ranged from 5.15 to 1980 mL per kg (mean, 136 mL/kg). Massive blood loss negatively affected survival not only immediately after operation (high blood loss [HBL]:low blood loss [LBL] ratio, 85.5%:93.9% at 1 month) but also over the long term (HBL:LBL, 61.4%:76.8% at 5 years). Preoperative risk factors for massive blood loss were determined to be recipient age (16.0 mg/dL), and blood urea nitrogen levels (>30.0 mg/dL).
CONCLUSIONS: The risk factors associated with massive intraoperative blood loss during LDLT were identified. This is the first analysis of blood loss during LDLT at a single center. Massive blood loss is a predictor of poor prognosis in LDLT patients. |
| doi_str_mv | 10.1111/j.1537-2995.2005.04330.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67903306</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67903306</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4360-59841224c10937d4721df431db11acf19152b6d4ec94a5923bff2f3f6d20cc113</originalsourceid><addsrcrecordid>eNqNkctu1DAUhi0EotPCKyBvYJfgaxKzQKIjplSqQKqKWFqOL8iDJw52Umbevk5n1G6xLB1f_vP7nM8AQIxqXMbHbY05bSsiBK8JQrxGjFJU71-A1dPFS7BCiOEKY0rOwHnOW4QQEQi_BmeYC8pEx1dgvh6mpOJok5r8vYV9iNHAEHOGZk5--A2Dv1-CiUNMy8YmWDKGPAY1TCUpDp-gGspU4ZB9htHBhnKYrPajt8OUoZqggrmYBAt1ObHpDXjlVMj27SlegJ-br3frb9XNj6vr9ZebSjPaoIqLjmFCmMZI0NawlmDjGMWmx1hphwXmpG8Ms1owxQWhvXPEUdcYgrQujV-AD0ffMcW_s82T3PmsbSil2zhn2bQCFXBNEXZHoU6l9WSdHJPfqXSQGMkFudzKhaxcyMoFuXxELvcl9d3pjbnfWfOceGJcBO9PApW1Cq7A0z4_65qufArqiu7zUffPB3v47wLk3e3mcVkMqqOBz5PdPxmo9Kc0Slsuf32_kmtGN7S9vJWCPgBvYKxM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67903306</pqid></control><display><type>article</type><title>Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yuasa, Takeshi ; Niwa, Norimi ; Kimura, Shinya ; Tsuji, Hiroaki ; Yurugi, Kimiko ; Egawa, Hiroto ; Tanaka, Koichi ; Asano, Hiroaki ; Maekawa, Taira</creator><creatorcontrib>Yuasa, Takeshi ; Niwa, Norimi ; Kimura, Shinya ; Tsuji, Hiroaki ; Yurugi, Kimiko ; Egawa, Hiroto ; Tanaka, Koichi ; Asano, Hiroaki ; Maekawa, Taira</creatorcontrib><description>BACKGROUND: Living‐donor liver transplantation (LDLT) has been an important option in the treatment of patients with end‐stage liver disease. Massive intraoperative blood loss can occur during LDLT, necessitating blood transfusion. The purpose of this study was to present blood loss data from the recipients of LDLT, to assess the effect of massive intraoperative blood loss on prognosis, and to assess the reliability of preoperative information in predicting intraoperative blood transfusion requirements in LDLT.
STUDY DESIGN AND METHODS: A total of 635 patients who underwent LDLTs between January 1995 and March 2002 at a university hospital were retro‐ spectively investigated. The volume of blood loss, prognosis, and preoperative variables were analyzed statistically.
RESULTS: Intraoperative blood loss ranged from 5.15 to 1980 mL per kg (mean, 136 mL/kg). Massive blood loss negatively affected survival not only immediately after operation (high blood loss [HBL]:low blood loss [LBL] ratio, 85.5%:93.9% at 1 month) but also over the long term (HBL:LBL, 61.4%:76.8% at 5 years). Preoperative risk factors for massive blood loss were determined to be recipient age (<1 years), weight (<10 kg), C‐reactive protein (>2 mg/dL), hematocrit (<30%), total bilirubin (>20.0 mg/dL), direct bilirubin (>16.0 mg/dL), and blood urea nitrogen levels (>30.0 mg/dL).
CONCLUSIONS: The risk factors associated with massive intraoperative blood loss during LDLT were identified. This is the first analysis of blood loss during LDLT at a single center. Massive blood loss is a predictor of poor prognosis in LDLT patients.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2005.04330.x</identifier><identifier>PMID: 15934985</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Oxford, UK and Malden, USA: Blackwell Science Inc</publisher><subject>Age Distribution ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Loss, Surgical ; Blood Transfusion ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Female ; Follow-Up Studies ; Humans ; Japan ; Liver Transplantation - mortality ; Liver, biliary tract, pancreas, portal circulation, spleen ; Living Donors ; Male ; Medical sciences ; Retrospective Studies ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Survival Analysis ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Treatment Outcome</subject><ispartof>Transfusion (Philadelphia, Pa.), 2005-06, Vol.45 (6), p.879-884</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4360-59841224c10937d4721df431db11acf19152b6d4ec94a5923bff2f3f6d20cc113</citedby><cites>FETCH-LOGICAL-c4360-59841224c10937d4721df431db11acf19152b6d4ec94a5923bff2f3f6d20cc113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2005.04330.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2005.04330.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16890108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15934985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuasa, Takeshi</creatorcontrib><creatorcontrib>Niwa, Norimi</creatorcontrib><creatorcontrib>Kimura, Shinya</creatorcontrib><creatorcontrib>Tsuji, Hiroaki</creatorcontrib><creatorcontrib>Yurugi, Kimiko</creatorcontrib><creatorcontrib>Egawa, Hiroto</creatorcontrib><creatorcontrib>Tanaka, Koichi</creatorcontrib><creatorcontrib>Asano, Hiroaki</creatorcontrib><creatorcontrib>Maekawa, Taira</creatorcontrib><title>Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Living‐donor liver transplantation (LDLT) has been an important option in the treatment of patients with end‐stage liver disease. Massive intraoperative blood loss can occur during LDLT, necessitating blood transfusion. The purpose of this study was to present blood loss data from the recipients of LDLT, to assess the effect of massive intraoperative blood loss on prognosis, and to assess the reliability of preoperative information in predicting intraoperative blood transfusion requirements in LDLT.
STUDY DESIGN AND METHODS: A total of 635 patients who underwent LDLTs between January 1995 and March 2002 at a university hospital were retro‐ spectively investigated. The volume of blood loss, prognosis, and preoperative variables were analyzed statistically.
RESULTS: Intraoperative blood loss ranged from 5.15 to 1980 mL per kg (mean, 136 mL/kg). Massive blood loss negatively affected survival not only immediately after operation (high blood loss [HBL]:low blood loss [LBL] ratio, 85.5%:93.9% at 1 month) but also over the long term (HBL:LBL, 61.4%:76.8% at 5 years). Preoperative risk factors for massive blood loss were determined to be recipient age (<1 years), weight (<10 kg), C‐reactive protein (>2 mg/dL), hematocrit (<30%), total bilirubin (>20.0 mg/dL), direct bilirubin (>16.0 mg/dL), and blood urea nitrogen levels (>30.0 mg/dL).
CONCLUSIONS: The risk factors associated with massive intraoperative blood loss during LDLT were identified. This is the first analysis of blood loss during LDLT at a single center. Massive blood loss is a predictor of poor prognosis in LDLT patients.</description><subject>Age Distribution</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Loss, Surgical</subject><subject>Blood Transfusion</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Japan</subject><subject>Liver Transplantation - mortality</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Survival Analysis</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Treatment Outcome</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0EotPCKyBvYJfgaxKzQKIjplSqQKqKWFqOL8iDJw52Umbevk5n1G6xLB1f_vP7nM8AQIxqXMbHbY05bSsiBK8JQrxGjFJU71-A1dPFS7BCiOEKY0rOwHnOW4QQEQi_BmeYC8pEx1dgvh6mpOJok5r8vYV9iNHAEHOGZk5--A2Dv1-CiUNMy8YmWDKGPAY1TCUpDp-gGspU4ZB9htHBhnKYrPajt8OUoZqggrmYBAt1ObHpDXjlVMj27SlegJ-br3frb9XNj6vr9ZebSjPaoIqLjmFCmMZI0NawlmDjGMWmx1hphwXmpG8Ms1owxQWhvXPEUdcYgrQujV-AD0ffMcW_s82T3PmsbSil2zhn2bQCFXBNEXZHoU6l9WSdHJPfqXSQGMkFudzKhaxcyMoFuXxELvcl9d3pjbnfWfOceGJcBO9PApW1Cq7A0z4_65qufArqiu7zUffPB3v47wLk3e3mcVkMqqOBz5PdPxmo9Kc0Slsuf32_kmtGN7S9vJWCPgBvYKxM</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Yuasa, Takeshi</creator><creator>Niwa, Norimi</creator><creator>Kimura, Shinya</creator><creator>Tsuji, Hiroaki</creator><creator>Yurugi, Kimiko</creator><creator>Egawa, Hiroto</creator><creator>Tanaka, Koichi</creator><creator>Asano, Hiroaki</creator><creator>Maekawa, Taira</creator><general>Blackwell Science Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center</title><author>Yuasa, Takeshi ; Niwa, Norimi ; Kimura, Shinya ; Tsuji, Hiroaki ; Yurugi, Kimiko ; Egawa, Hiroto ; Tanaka, Koichi ; Asano, Hiroaki ; Maekawa, Taira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4360-59841224c10937d4721df431db11acf19152b6d4ec94a5923bff2f3f6d20cc113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age Distribution</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Loss, Surgical</topic><topic>Blood Transfusion</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Japan</topic><topic>Liver Transplantation - mortality</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Survival Analysis</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuasa, Takeshi</creatorcontrib><creatorcontrib>Niwa, Norimi</creatorcontrib><creatorcontrib>Kimura, Shinya</creatorcontrib><creatorcontrib>Tsuji, Hiroaki</creatorcontrib><creatorcontrib>Yurugi, Kimiko</creatorcontrib><creatorcontrib>Egawa, Hiroto</creatorcontrib><creatorcontrib>Tanaka, Koichi</creatorcontrib><creatorcontrib>Asano, Hiroaki</creatorcontrib><creatorcontrib>Maekawa, Taira</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuasa, Takeshi</au><au>Niwa, Norimi</au><au>Kimura, Shinya</au><au>Tsuji, Hiroaki</au><au>Yurugi, Kimiko</au><au>Egawa, Hiroto</au><au>Tanaka, Koichi</au><au>Asano, Hiroaki</au><au>Maekawa, Taira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2005-06</date><risdate>2005</risdate><volume>45</volume><issue>6</issue><spage>879</spage><epage>884</epage><pages>879-884</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Living‐donor liver transplantation (LDLT) has been an important option in the treatment of patients with end‐stage liver disease. Massive intraoperative blood loss can occur during LDLT, necessitating blood transfusion. The purpose of this study was to present blood loss data from the recipients of LDLT, to assess the effect of massive intraoperative blood loss on prognosis, and to assess the reliability of preoperative information in predicting intraoperative blood transfusion requirements in LDLT.
STUDY DESIGN AND METHODS: A total of 635 patients who underwent LDLTs between January 1995 and March 2002 at a university hospital were retro‐ spectively investigated. The volume of blood loss, prognosis, and preoperative variables were analyzed statistically.
RESULTS: Intraoperative blood loss ranged from 5.15 to 1980 mL per kg (mean, 136 mL/kg). Massive blood loss negatively affected survival not only immediately after operation (high blood loss [HBL]:low blood loss [LBL] ratio, 85.5%:93.9% at 1 month) but also over the long term (HBL:LBL, 61.4%:76.8% at 5 years). Preoperative risk factors for massive blood loss were determined to be recipient age (<1 years), weight (<10 kg), C‐reactive protein (>2 mg/dL), hematocrit (<30%), total bilirubin (>20.0 mg/dL), direct bilirubin (>16.0 mg/dL), and blood urea nitrogen levels (>30.0 mg/dL).
CONCLUSIONS: The risk factors associated with massive intraoperative blood loss during LDLT were identified. This is the first analysis of blood loss during LDLT at a single center. Massive blood loss is a predictor of poor prognosis in LDLT patients.</abstract><cop>Oxford, UK and Malden, USA</cop><pub>Blackwell Science Inc</pub><pmid>15934985</pmid><doi>10.1111/j.1537-2995.2005.04330.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Distribution Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Loss, Surgical Blood Transfusion Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Female Follow-Up Studies Humans Japan Liver Transplantation - mortality Liver, biliary tract, pancreas, portal circulation, spleen Living Donors Male Medical sciences Retrospective Studies Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival Analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Treatment Outcome |
| title | Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center |
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