Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis
Plant cells have two defense systems that detect bacterial pathogens. One is a basal defense system that recognizes complex pathogen-associated molecular patterns (PAMPs). A second system uses disease-resistance (R) proteins to recognize type lll effector proteins that are delivered into the plant c...
Gespeichert in:
| Veröffentlicht in: | Cell 2005-06, Vol.121 (5), p.749-759 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 759 |
|---|---|
| container_issue | 5 |
| container_start_page | 749 |
| container_title | Cell |
| container_volume | 121 |
| creator | Kim, Min Gab da Cunha, Luis McFall, Aidan J. Belkhadir, Youssef DebRoy, Sruti Dangl, Jeffrey L. Mackey, David |
| description | Plant cells have two defense systems that detect bacterial pathogens. One is a basal defense system that recognizes complex pathogen-associated molecular patterns (PAMPs). A second system uses disease-resistance (R) proteins to recognize type lll effector proteins that are delivered into the plant cell by the pathogen’s type III secretion system. Here we show that these two pathways are linked. We find that two
Pseudomonas syringae type III effectors, AvrRpt2 and AvrRpm1, inhibit PAMP-induced signaling and thus compromise the host's basal defense system. RIN4 is an
Arabidopsis protein targeted by AvrRpt2 and AvrRpm1 for degradation and phosphorylation, respectively. We find that RIN4 is itself a regulator of PAMP signaling. The R proteins, RPS2 and RPM1, sense type III effector-induced perturbations of RIN4. Thus, R proteins guard the plant against type III effectors that inhibit PAMP signaling and provide a mechanistic link between the two plant defense systems. |
| doi_str_mv | 10.1016/j.cell.2005.03.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67902419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0092867405002977</els_id><sourcerecordid>67902419</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4105-63e59a6988b1c5c812d4784b6dae64320cd2ff71c807a5629e97a587d3efb2273</originalsourceid><addsrcrecordid>eNqFkM1u1DAURi0EotPCC7BAXrFLuHbiP4lNKaVEqgBVw9py7JviUSYe7EnRvD0ZzUjsYPVtzncWh5A3DGoGTL7f1B7HseYAooamBi6ekRUDo6qWKf6crAAMr7RU7QW5LGUDAFoI8ZJcMGEaoSRbEbv-nej3gnNI2zS5Qsshx-nRIV0fdki7rqO3w4B-n3Kh3fQz9nFPH7qvbfWAj_Po9hjoR1fcSD_hgFNBGid6nV0fQ9qVWF6RF4MbC74-7xX58fl2ffOluv92191c31e-ZSAq2aAwThqte-aF14yHVum2l8GhbBsOPvBhUMxrUE5IbtAsq1VocOg5V80VeXfy7nL6NWPZ220sxzxuwjQXK5UB3jLzX5CpRmkFegH5CfQ5lZJxsLscty4fLAN77G839vizx_4WGrv0X05vz_a532L4ezkHX4APJwCXGE8Rsy0-4uQxxLxUtiHFf_n_AMhGlU4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17378708</pqid></control><display><type>article</type><title>Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Kim, Min Gab ; da Cunha, Luis ; McFall, Aidan J. ; Belkhadir, Youssef ; DebRoy, Sruti ; Dangl, Jeffrey L. ; Mackey, David</creator><creatorcontrib>Kim, Min Gab ; da Cunha, Luis ; McFall, Aidan J. ; Belkhadir, Youssef ; DebRoy, Sruti ; Dangl, Jeffrey L. ; Mackey, David</creatorcontrib><description>Plant cells have two defense systems that detect bacterial pathogens. One is a basal defense system that recognizes complex pathogen-associated molecular patterns (PAMPs). A second system uses disease-resistance (R) proteins to recognize type lll effector proteins that are delivered into the plant cell by the pathogen’s type III secretion system. Here we show that these two pathways are linked. We find that two
Pseudomonas syringae type III effectors, AvrRpt2 and AvrRpm1, inhibit PAMP-induced signaling and thus compromise the host's basal defense system. RIN4 is an
Arabidopsis protein targeted by AvrRpt2 and AvrRpm1 for degradation and phosphorylation, respectively. We find that RIN4 is itself a regulator of PAMP signaling. The R proteins, RPS2 and RPM1, sense type III effector-induced perturbations of RIN4. Thus, R proteins guard the plant against type III effectors that inhibit PAMP signaling and provide a mechanistic link between the two plant defense systems.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2005.03.025</identifier><identifier>PMID: 15935761</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arabidopsis - metabolism ; Arabidopsis - microbiology ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Bacterial Outer Membrane Proteins - metabolism ; Bacterial Proteins - metabolism ; Carrier Proteins - metabolism ; Glucans - metabolism ; Glucosyltransferases - metabolism ; Protein Kinases - metabolism ; Pseudomonas syringae ; Pseudomonas syringae - pathogenicity</subject><ispartof>Cell, 2005-06, Vol.121 (5), p.749-759</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4105-63e59a6988b1c5c812d4784b6dae64320cd2ff71c807a5629e97a587d3efb2273</citedby><cites>FETCH-LOGICAL-c4105-63e59a6988b1c5c812d4784b6dae64320cd2ff71c807a5629e97a587d3efb2273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cell.2005.03.025$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15935761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Min Gab</creatorcontrib><creatorcontrib>da Cunha, Luis</creatorcontrib><creatorcontrib>McFall, Aidan J.</creatorcontrib><creatorcontrib>Belkhadir, Youssef</creatorcontrib><creatorcontrib>DebRoy, Sruti</creatorcontrib><creatorcontrib>Dangl, Jeffrey L.</creatorcontrib><creatorcontrib>Mackey, David</creatorcontrib><title>Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis</title><title>Cell</title><addtitle>Cell</addtitle><description>Plant cells have two defense systems that detect bacterial pathogens. One is a basal defense system that recognizes complex pathogen-associated molecular patterns (PAMPs). A second system uses disease-resistance (R) proteins to recognize type lll effector proteins that are delivered into the plant cell by the pathogen’s type III secretion system. Here we show that these two pathways are linked. We find that two
Pseudomonas syringae type III effectors, AvrRpt2 and AvrRpm1, inhibit PAMP-induced signaling and thus compromise the host's basal defense system. RIN4 is an
Arabidopsis protein targeted by AvrRpt2 and AvrRpm1 for degradation and phosphorylation, respectively. We find that RIN4 is itself a regulator of PAMP signaling. The R proteins, RPS2 and RPM1, sense type III effector-induced perturbations of RIN4. Thus, R proteins guard the plant against type III effectors that inhibit PAMP signaling and provide a mechanistic link between the two plant defense systems.</description><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis - microbiology</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Bacterial Outer Membrane Proteins - metabolism</subject><subject>Bacterial Proteins - metabolism</subject><subject>Carrier Proteins - metabolism</subject><subject>Glucans - metabolism</subject><subject>Glucosyltransferases - metabolism</subject><subject>Protein Kinases - metabolism</subject><subject>Pseudomonas syringae</subject><subject>Pseudomonas syringae - pathogenicity</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1u1DAURi0EotPCC7BAXrFLuHbiP4lNKaVEqgBVw9py7JviUSYe7EnRvD0ZzUjsYPVtzncWh5A3DGoGTL7f1B7HseYAooamBi6ekRUDo6qWKf6crAAMr7RU7QW5LGUDAFoI8ZJcMGEaoSRbEbv-nej3gnNI2zS5Qsshx-nRIV0fdki7rqO3w4B-n3Kh3fQz9nFPH7qvbfWAj_Po9hjoR1fcSD_hgFNBGid6nV0fQ9qVWF6RF4MbC74-7xX58fl2ffOluv92191c31e-ZSAq2aAwThqte-aF14yHVum2l8GhbBsOPvBhUMxrUE5IbtAsq1VocOg5V80VeXfy7nL6NWPZ220sxzxuwjQXK5UB3jLzX5CpRmkFegH5CfQ5lZJxsLscty4fLAN77G839vizx_4WGrv0X05vz_a532L4ezkHX4APJwCXGE8Rsy0-4uQxxLxUtiHFf_n_AMhGlU4</recordid><startdate>20050603</startdate><enddate>20050603</enddate><creator>Kim, Min Gab</creator><creator>da Cunha, Luis</creator><creator>McFall, Aidan J.</creator><creator>Belkhadir, Youssef</creator><creator>DebRoy, Sruti</creator><creator>Dangl, Jeffrey L.</creator><creator>Mackey, David</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050603</creationdate><title>Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis</title><author>Kim, Min Gab ; da Cunha, Luis ; McFall, Aidan J. ; Belkhadir, Youssef ; DebRoy, Sruti ; Dangl, Jeffrey L. ; Mackey, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4105-63e59a6988b1c5c812d4784b6dae64320cd2ff71c807a5629e97a587d3efb2273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis - microbiology</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Arabidopsis thaliana</topic><topic>Bacterial Outer Membrane Proteins - metabolism</topic><topic>Bacterial Proteins - metabolism</topic><topic>Carrier Proteins - metabolism</topic><topic>Glucans - metabolism</topic><topic>Glucosyltransferases - metabolism</topic><topic>Protein Kinases - metabolism</topic><topic>Pseudomonas syringae</topic><topic>Pseudomonas syringae - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Min Gab</creatorcontrib><creatorcontrib>da Cunha, Luis</creatorcontrib><creatorcontrib>McFall, Aidan J.</creatorcontrib><creatorcontrib>Belkhadir, Youssef</creatorcontrib><creatorcontrib>DebRoy, Sruti</creatorcontrib><creatorcontrib>Dangl, Jeffrey L.</creatorcontrib><creatorcontrib>Mackey, David</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Min Gab</au><au>da Cunha, Luis</au><au>McFall, Aidan J.</au><au>Belkhadir, Youssef</au><au>DebRoy, Sruti</au><au>Dangl, Jeffrey L.</au><au>Mackey, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2005-06-03</date><risdate>2005</risdate><volume>121</volume><issue>5</issue><spage>749</spage><epage>759</epage><pages>749-759</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Plant cells have two defense systems that detect bacterial pathogens. One is a basal defense system that recognizes complex pathogen-associated molecular patterns (PAMPs). A second system uses disease-resistance (R) proteins to recognize type lll effector proteins that are delivered into the plant cell by the pathogen’s type III secretion system. Here we show that these two pathways are linked. We find that two
Pseudomonas syringae type III effectors, AvrRpt2 and AvrRpm1, inhibit PAMP-induced signaling and thus compromise the host's basal defense system. RIN4 is an
Arabidopsis protein targeted by AvrRpt2 and AvrRpm1 for degradation and phosphorylation, respectively. We find that RIN4 is itself a regulator of PAMP signaling. The R proteins, RPS2 and RPM1, sense type III effector-induced perturbations of RIN4. Thus, R proteins guard the plant against type III effectors that inhibit PAMP signaling and provide a mechanistic link between the two plant defense systems.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15935761</pmid><doi>10.1016/j.cell.2005.03.025</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 2005-06, Vol.121 (5), p.749-759 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67902419 |
| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Arabidopsis - metabolism Arabidopsis - microbiology Arabidopsis Proteins - metabolism Arabidopsis thaliana Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - metabolism Carrier Proteins - metabolism Glucans - metabolism Glucosyltransferases - metabolism Protein Kinases - metabolism Pseudomonas syringae Pseudomonas syringae - pathogenicity |
| title | Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T03%3A07%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20Pseudomonas%20syringae%20Type%20III%20Effectors%20Inhibit%20RIN4-Regulated%20Basal%20Defense%20in%20Arabidopsis&rft.jtitle=Cell&rft.au=Kim,%20Min%20Gab&rft.date=2005-06-03&rft.volume=121&rft.issue=5&rft.spage=749&rft.epage=759&rft.pages=749-759&rft.issn=0092-8674&rft.eissn=1097-4172&rft_id=info:doi/10.1016/j.cell.2005.03.025&rft_dat=%3Cproquest_cross%3E67902419%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17378708&rft_id=info:pmid/15935761&rft_els_id=S0092867405002977&rfr_iscdi=true |