Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow

Cells in vivo are constantly subjected to mechanical shear stresses that play important regulatory roles in various physiological and pathological processes. Cytoskeletal reorganizations that occur in response to shear flow have been studied extensively, but whether the cytoplasm of an adherent cell...

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Veröffentlicht in:	Journal of cell science 2006-05, Vol.119 (9), p.1760-1768
Hauptverfasser:	Lee, Jerry S. H, Panorchan, Porntula, Hale, Christopher M, Khatau, Shyam B, Kole, Thomas P, Tseng, Yiider, Wirtz, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Actins - metabolism Animals Cell Adhesion - physiology Cytoskeleton - metabolism Cytosol - chemistry Cytosol - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fluorescent Dyes - metabolism Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Lysophospholipids - metabolism Mice Microinjections - instrumentation Microinjections - methods Myosins - metabolism Nanoparticles Nanotechnology - instrumentation Nanotechnology - methods Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Rheology - instrumentation Rheology - methods rho-Associated Kinases Shear Strength Signal Transduction - physiology Stress, Mechanical
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