Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells

The transmembrane chemokine CXCL16 is expressed by dendritic and vascular cells and mediates chemotaxis and adhesion of activated T cells via the chemokine receptor CXCR6/Bonzo. Here we describe the expression and shedding of this chemokine by glioma cells in situ and in vitro. By quantitative RT‐PC...

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Veröffentlicht in:	Journal of neurochemistry 2005-06, Vol.93 (5), p.1293-1303
Hauptverfasser:	Ludwig, Andreas, Schulte, Alexander, Schnack, Cathrin, Hundhausen, Christian, Reiss, Karina, Brodway, Neil, Held‐Feindt, Janka, Mentlein, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocytes Astrocytes - metabolism Biological and medical sciences Brain Cell culture Cell Line, Tumor Chemokine CXCL16 Chemokine CXCL6 chemokines Chemokines, CXC - chemistry Chemokines, CXC - genetics Chemokines, CXC - metabolism cytokines Fundamental and applied biological sciences. Psychology glioma Glioma - metabolism Glioma - pathology Humans Interferon-gamma - pharmacology Isolated neuron and nerve. Neuroglia Medical sciences Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Metalloproteases - metabolism metalloproteinases Mice Microglia - metabolism Neuroglia - metabolism Neurology Neurons Proteins Receptors, Immunologic - chemistry Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Scavenger Recombinant Proteins - pharmacology RNA, Messenger - metabolism shedding Solubility Tissue Culture Techniques Tumor Necrosis Factor-alpha - pharmacology Tumors of the nervous system. Phacomatoses Up-Regulation Vertebrates: nervous system and sense organs
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