Lipopolysaccharide Improves Cardiomyocyte Survival and Function after Serum Deprivation

Toll-like receptor-4 (TLR4) and its signaling molecule interleukin-1 receptor-associated kinase (IRAK-1) play an important role in host defense and tissue inflammation. Intriguingly, systemic administration of lipopolysaccharide (LPS), the agonist for TLR4, confers a cardio-protective effect against...

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (23), p.21997-22005
Hauptverfasser:	Chao, Wei, Shen, Yan, Zhu, Xinsheng, Zhao, Huailong, Novikov, Mikhail, Schmidt, Ulrich, Rosenzweig, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Androstadienes - pharmacology Animals Animals, Newborn Apoptosis Blotting, Western Calcium - metabolism Caspase 3 Caspases - metabolism Cell Survival Culture Media, Serum-Free - pharmacology DNA - chemistry DNA Fragmentation Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Flavonoids - pharmacology Green Fluorescent Proteins - metabolism Histones - chemistry Hypoxia Immunoprecipitation Interleukin-1 Receptor-Associated Kinases Ischemia Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Myocytes, Cardiac - cytology Phosphatidylinositol 3-Kinases - metabolism Protein Kinases - metabolism Protein Kinases - physiology Rats Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology Recombinant Proteins - metabolism Signal Transduction Time Factors Toll-Like Receptor 4 Toll-Like Receptors Transgenes Wortmannin
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