Identification and characterization of the human SCAN domain zinc-finger gene ZNF449
Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching...
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| Veröffentlicht in: | Molecular biology reports 2006-03, Vol.33 (1), p.51-57 |
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| creator | Luo, Kuntian Li, Jie Cui, Yanhui Xu, Meng Yuan, Jian Tang, Wenwen Wan, Bo Yu, Long |
| description | Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C(2)H(2) (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor. |
| doi_str_mv | 10.1007/s11033-005-3966-0 |
| format | Article |
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In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C(2)H(2) (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-005-3966-0</identifier><identifier>PMID: 16636917</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Animals ; Apoptosis ; C-Terminus ; Cell differentiation ; Cell proliferation ; DNA, Complementary - genetics ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Gene Expression ; HeLa Cells ; Humans ; Molecular Sequence Data ; N-Terminus ; Nucleotides ; Phylogeny ; Protein Structure, Tertiary ; Proteins ; Sequence Alignment ; Sequence Homology, Amino Acid ; Zinc finger proteins ; Zinc Fingers</subject><ispartof>Molecular biology reports, 2006-03, Vol.33 (1), p.51-57</ispartof><rights>Springer 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-8028be53f0f4a47401d60a1630e175cb4ca697cfbb884cb2b850cde0390abbf63</citedby><cites>FETCH-LOGICAL-c451t-8028be53f0f4a47401d60a1630e175cb4ca697cfbb884cb2b850cde0390abbf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16636917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Kuntian</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Cui, Yanhui</creatorcontrib><creatorcontrib>Xu, Meng</creatorcontrib><creatorcontrib>Yuan, Jian</creatorcontrib><creatorcontrib>Tang, Wenwen</creatorcontrib><creatorcontrib>Wan, Bo</creatorcontrib><creatorcontrib>Yu, Long</creatorcontrib><title>Identification and characterization of the human SCAN domain zinc-finger gene ZNF449</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><description>Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. 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In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C(2)H(2) (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>16636917</pmid><doi>10.1007/s11033-005-3966-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Apoptosis C-Terminus Cell differentiation Cell proliferation DNA, Complementary - genetics DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression HeLa Cells Humans Molecular Sequence Data N-Terminus Nucleotides Phylogeny Protein Structure, Tertiary Proteins Sequence Alignment Sequence Homology, Amino Acid Zinc finger proteins Zinc Fingers |
| title | Identification and characterization of the human SCAN domain zinc-finger gene ZNF449 |
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