Bone mineral density in malnourished children without rachitic manifestations
Background: The purpose of this study was to determine bone mineral density (BMD) of lumbar spine in malnourished children without rachitic manifestations, before and after dietary treatment and vitamin D supplementation, and to compare with healthy children of the same community. Methods: The subje...
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| Veröffentlicht in: | Pediatrics international 2006-04, Vol.48 (2), p.128-131 |
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| creator | ALP, HANDAN ORBAK, ZERRIN KERMEN, TAHIR USLU, HATICE |
| description | Background: The purpose of this study was to determine bone mineral density (BMD) of lumbar spine in malnourished children without rachitic manifestations, before and after dietary treatment and vitamin D supplementation, and to compare with healthy children of the same community.
Methods: The subjects were 41 children with malnutrition and 21 healthy controls. None of the children had clinical, biochemical and/or radiological rickets features. The patients had moderate 15 and severe 26 malnutrition according to Gomez's criteria. Using the Wellcome Classification, marasmus was diagnosed in 16 children, kwashiorkor in 10 children. The children with malnutrition were given vitamin D supplementation.
Results: BMD was lower in children with malnutrition than in controls (P |
| doi_str_mv | 10.1111/j.1442-200X.2006.02184.x |
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Methods: The subjects were 41 children with malnutrition and 21 healthy controls. None of the children had clinical, biochemical and/or radiological rickets features. The patients had moderate 15 and severe 26 malnutrition according to Gomez's criteria. Using the Wellcome Classification, marasmus was diagnosed in 16 children, kwashiorkor in 10 children. The children with malnutrition were given vitamin D supplementation.
Results: BMD was lower in children with malnutrition than in controls (P < 0.01). Mineralization significantly effected the severity of malnutrition (P < 0.01). BMD in kwashiorkor was similar to that of marasmus. The mean BMD level of infants receiving 400 IU of vitamin D daily was similar to that of infants receiving 800 IU of vitamin D daily at the beginning of treatment. In two suplementation groups, the BMD gradually increased during the first 3 months of treatment, but this increase in the infants receiving 800 IU of vitamin D daily was significantly higher than that in the infants receiving 400 IU of vitamin D daily.
Conclusion: Measurements of BMD in children with malnutrition, especially severe malnutrition, are to be recommended in the initial assessment of the severity of osteopenia and in the follow up to monitor the response to therapy. Children with malnutrition should be given 800 IU of vitamin D daily. The loss of BMD must be accepted as a complication of malnutrition.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/j.1442-200X.2006.02184.x</identifier><identifier>PMID: 16635170</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Absorptiometry, Photon ; Bone Density - drug effects ; Bone Diseases, Metabolic - etiology ; bone mineral density ; Female ; Humans ; Infant ; Male ; malnutrition ; Malnutrition - complications ; Malnutrition - physiopathology ; Vitamin D - therapeutic use ; vitamin D treatment</subject><ispartof>Pediatrics international, 2006-04, Vol.48 (2), p.128-131</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5394-e9e684c3a81fc397824a9294ed4872c94b4c1ba1a9ff00cecab348ae01f9dcaf3</citedby><cites>FETCH-LOGICAL-c5394-e9e684c3a81fc397824a9294ed4872c94b4c1ba1a9ff00cecab348ae01f9dcaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-200X.2006.02184.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-200X.2006.02184.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16635170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALP, HANDAN</creatorcontrib><creatorcontrib>ORBAK, ZERRIN</creatorcontrib><creatorcontrib>KERMEN, TAHIR</creatorcontrib><creatorcontrib>USLU, HATICE</creatorcontrib><title>Bone mineral density in malnourished children without rachitic manifestations</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background: The purpose of this study was to determine bone mineral density (BMD) of lumbar spine in malnourished children without rachitic manifestations, before and after dietary treatment and vitamin D supplementation, and to compare with healthy children of the same community.
Methods: The subjects were 41 children with malnutrition and 21 healthy controls. None of the children had clinical, biochemical and/or radiological rickets features. The patients had moderate 15 and severe 26 malnutrition according to Gomez's criteria. Using the Wellcome Classification, marasmus was diagnosed in 16 children, kwashiorkor in 10 children. The children with malnutrition were given vitamin D supplementation.
Results: BMD was lower in children with malnutrition than in controls (P < 0.01). Mineralization significantly effected the severity of malnutrition (P < 0.01). BMD in kwashiorkor was similar to that of marasmus. The mean BMD level of infants receiving 400 IU of vitamin D daily was similar to that of infants receiving 800 IU of vitamin D daily at the beginning of treatment. In two suplementation groups, the BMD gradually increased during the first 3 months of treatment, but this increase in the infants receiving 800 IU of vitamin D daily was significantly higher than that in the infants receiving 400 IU of vitamin D daily.
Conclusion: Measurements of BMD in children with malnutrition, especially severe malnutrition, are to be recommended in the initial assessment of the severity of osteopenia and in the follow up to monitor the response to therapy. Children with malnutrition should be given 800 IU of vitamin D daily. The loss of BMD must be accepted as a complication of malnutrition.</description><subject>Absorptiometry, Photon</subject><subject>Bone Density - drug effects</subject><subject>Bone Diseases, Metabolic - etiology</subject><subject>bone mineral density</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>malnutrition</subject><subject>Malnutrition - complications</subject><subject>Malnutrition - physiopathology</subject><subject>Vitamin D - therapeutic use</subject><subject>vitamin D treatment</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0E4lH4BZQVuwQ7dhN7wQIKFMRbAsHOcp2J6pI4YCei_XscWpUleDEeec6d8VyEIoITEs7xLCGMpXGK8VsSQpbglHCWzDfQ7rqwGXKa8pjjLN9Be97PMMY852wb7ZAso0OS4110d9ZYiGpjwakqKsB60y4iY6NaVbbpnPFTKCI9NVXhwEZfpp02XRs5FZ5aowNmTQm-Va1prN9HW6WqPBys7gF6ubx4Hl3Ftw_j69HpbayHVLAYBGScaao4KTUVOU-ZEqlgUDCep1qwCdNkoogSZYmxBq0mlHEFmJSi0KqkA3S07Pvhms8ujJe18RqqSlloOi-zXGCSCvInSAQLP-J5APkS1K7x3kEpP5yplVtIgmXvuZzJ3lrZW9uHTP54LudBeria0U1qKH6FK5MDcLIEvkwFi383lo8X530W9PFSb3wL87VeufewKM2H8vV-LIeMi-ebJyIz-g3ZeqCI</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>ALP, HANDAN</creator><creator>ORBAK, ZERRIN</creator><creator>KERMEN, TAHIR</creator><creator>USLU, HATICE</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Bone mineral density in malnourished children without rachitic manifestations</title><author>ALP, HANDAN ; ORBAK, ZERRIN ; KERMEN, TAHIR ; USLU, HATICE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5394-e9e684c3a81fc397824a9294ed4872c94b4c1ba1a9ff00cecab348ae01f9dcaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorptiometry, Photon</topic><topic>Bone Density - drug effects</topic><topic>Bone Diseases, Metabolic - etiology</topic><topic>bone mineral density</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>malnutrition</topic><topic>Malnutrition - complications</topic><topic>Malnutrition - physiopathology</topic><topic>Vitamin D - therapeutic use</topic><topic>vitamin D treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALP, HANDAN</creatorcontrib><creatorcontrib>ORBAK, ZERRIN</creatorcontrib><creatorcontrib>KERMEN, TAHIR</creatorcontrib><creatorcontrib>USLU, HATICE</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALP, HANDAN</au><au>ORBAK, ZERRIN</au><au>KERMEN, TAHIR</au><au>USLU, HATICE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone mineral density in malnourished children without rachitic manifestations</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2006-04</date><risdate>2006</risdate><volume>48</volume><issue>2</issue><spage>128</spage><epage>131</epage><pages>128-131</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background: The purpose of this study was to determine bone mineral density (BMD) of lumbar spine in malnourished children without rachitic manifestations, before and after dietary treatment and vitamin D supplementation, and to compare with healthy children of the same community.
Methods: The subjects were 41 children with malnutrition and 21 healthy controls. None of the children had clinical, biochemical and/or radiological rickets features. The patients had moderate 15 and severe 26 malnutrition according to Gomez's criteria. Using the Wellcome Classification, marasmus was diagnosed in 16 children, kwashiorkor in 10 children. The children with malnutrition were given vitamin D supplementation.
Results: BMD was lower in children with malnutrition than in controls (P < 0.01). Mineralization significantly effected the severity of malnutrition (P < 0.01). BMD in kwashiorkor was similar to that of marasmus. The mean BMD level of infants receiving 400 IU of vitamin D daily was similar to that of infants receiving 800 IU of vitamin D daily at the beginning of treatment. In two suplementation groups, the BMD gradually increased during the first 3 months of treatment, but this increase in the infants receiving 800 IU of vitamin D daily was significantly higher than that in the infants receiving 400 IU of vitamin D daily.
Conclusion: Measurements of BMD in children with malnutrition, especially severe malnutrition, are to be recommended in the initial assessment of the severity of osteopenia and in the follow up to monitor the response to therapy. Children with malnutrition should be given 800 IU of vitamin D daily. The loss of BMD must be accepted as a complication of malnutrition.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>16635170</pmid><doi>10.1111/j.1442-200X.2006.02184.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Absorptiometry, Photon Bone Density - drug effects Bone Diseases, Metabolic - etiology bone mineral density Female Humans Infant Male malnutrition Malnutrition - complications Malnutrition - physiopathology Vitamin D - therapeutic use vitamin D treatment |
| title | Bone mineral density in malnourished children without rachitic manifestations |
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