Down-regulation of Human DAB2IP Gene Expression Mediated by Polycomb Ezh2 Complex and Histone Deacetylase in Prostate Cancer

Human DAB2IP (hDAB2IP), a novel GTPase-activating protein modulating the Ras-mediated signaling and tumor necrosis factor-mediated apoptosis, is a potent growth inhibitor in human prostate cancer (PCa). Loss of hDAB2IP expression in PCa is due to altered epigenetic regulation (i.e. DNA methylation a...

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (23), p.22437-22444
Hauptverfasser:	Chen, Hong, Tu, Szu-wei, Hsieh, Jer-Tsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Line, Tumor Chromatin Immunoprecipitation Disease Progression DNA Methylation DNA, Complementary - metabolism DNA-Binding Proteins Down-Regulation Enhancer of Zeste Homolog 2 Protein Epithelial Cells - metabolism Gene Expression Regulation Gene Expression Regulation, Neoplastic Genes, Reporter Histone Deacetylase 1 Histone Deacetylases - metabolism Histone Methyltransferases Histone-Lysine N-Methyltransferase - metabolism Histones - chemistry Humans Luciferases - metabolism Male Neoplasm Metastasis Polycomb Repressive Complex 2 Promoter Regions, Genetic Prostate - metabolism Prostatic Neoplasms - enzymology Protein Binding Protein Methyltransferases Proteins - metabolism ras GTPase-Activating Proteins - biosynthesis RNA Interference RNA, Small Interfering - metabolism Time Factors Transcription Factors Transfection
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