Hyperbaric Oxygen Preconditioning Induces Tolerance against Spinal Cord Ischemia by Upregulation of Antioxidant Enzymes in Rabbits
The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White r...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2006-05, Vol.26 (5), p.666-674 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | Nie, Huang Xiong, Lize Lao, Ning Chen, Shaoyang Xu, Ning Zhu, Zhenghua |
| description | The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham pretreatment once daily for five consecutive days before spinal cord ischemia. Activities of catalase (CAT) and superoxide dismutase were increased in spinal cord tissue in the HBO group 24 h after the last pretreatment and reached a higher level after spinal cord ischemia for 20 mins followed by reperfusion for 24 or 48 h, in comparison with those in control and HBA groups. The spinal cord ischemic tolerance induced by HBO preconditioning was attenuated when a CAT inhibitor, 3-amino-1,2,4-triazole,1 g/kg, was administered intraperitoneally 1 h before ischemia. In addition, administration of a free radical scavenger, dimethylthiourea, 500 mg/kg, intravenous, 1 h before each day's preconditioning, reversed the increase of the activities of both enzymes in spinal cord tissue. The results indicate that an initial oxidative stress, as a trigger to upregulate the antioxidant enzyme activities, plays an important role in the formation of the tolerance against spinal cord ischemia by HBO preconditioning. |
| doi_str_mv | 10.1038/sj.jcbfm.9600221 |
| format | Article |
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New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham pretreatment once daily for five consecutive days before spinal cord ischemia. Activities of catalase (CAT) and superoxide dismutase were increased in spinal cord tissue in the HBO group 24 h after the last pretreatment and reached a higher level after spinal cord ischemia for 20 mins followed by reperfusion for 24 or 48 h, in comparison with those in control and HBA groups. The spinal cord ischemic tolerance induced by HBO preconditioning was attenuated when a CAT inhibitor, 3-amino-1,2,4-triazole,1 g/kg, was administered intraperitoneally 1 h before ischemia. In addition, administration of a free radical scavenger, dimethylthiourea, 500 mg/kg, intravenous, 1 h before each day's preconditioning, reversed the increase of the activities of both enzymes in spinal cord tissue. The results indicate that an initial oxidative stress, as a trigger to upregulate the antioxidant enzyme activities, plays an important role in the formation of the tolerance against spinal cord ischemia by HBO preconditioning.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1038/sj.jcbfm.9600221</identifier><identifier>PMID: 16136055</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Amitrole - metabolism ; Animals ; Antihypertensive agents ; Antioxidants - metabolism ; Behavior, Animal ; Biological and medical sciences ; Cardiovascular system ; Catalase - metabolism ; Enzyme Inhibitors - metabolism ; Glutathione Peroxidase - metabolism ; Hyperbaric Oxygenation ; Ischemic Preconditioning ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Neurology ; Neurons - metabolism ; Neuropharmacology ; Neuroprotective agent ; Oxidative Stress ; Pharmacology. Drug treatments ; Rabbits ; Reperfusion ; Spinal Cord Ischemia - metabolism ; Spinal Cord Ischemia - prevention & control ; Superoxide Dismutase - metabolism ; Up-Regulation ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of cerebral blood flow and metabolism, 2006-05, Vol.26 (5), p.666-674</ispartof><rights>2006 ISCBFM</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-a3c0d4ec49248a796444b2cf297d003ff89e44cf04f59dc9e74c672b884d2bc73</citedby><cites>FETCH-LOGICAL-c434t-a3c0d4ec49248a796444b2cf297d003ff89e44cf04f59dc9e74c672b884d2bc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600221$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1038/sj.jcbfm.9600221$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17741937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16136055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, Huang</creatorcontrib><creatorcontrib>Xiong, Lize</creatorcontrib><creatorcontrib>Lao, Ning</creatorcontrib><creatorcontrib>Chen, Shaoyang</creatorcontrib><creatorcontrib>Xu, Ning</creatorcontrib><creatorcontrib>Zhu, Zhenghua</creatorcontrib><title>Hyperbaric Oxygen Preconditioning Induces Tolerance against Spinal Cord Ischemia by Upregulation of Antioxidant Enzymes in Rabbits</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham pretreatment once daily for five consecutive days before spinal cord ischemia. Activities of catalase (CAT) and superoxide dismutase were increased in spinal cord tissue in the HBO group 24 h after the last pretreatment and reached a higher level after spinal cord ischemia for 20 mins followed by reperfusion for 24 or 48 h, in comparison with those in control and HBA groups. The spinal cord ischemic tolerance induced by HBO preconditioning was attenuated when a CAT inhibitor, 3-amino-1,2,4-triazole,1 g/kg, was administered intraperitoneally 1 h before ischemia. In addition, administration of a free radical scavenger, dimethylthiourea, 500 mg/kg, intravenous, 1 h before each day's preconditioning, reversed the increase of the activities of both enzymes in spinal cord tissue. The results indicate that an initial oxidative stress, as a trigger to upregulate the antioxidant enzyme activities, plays an important role in the formation of the tolerance against spinal cord ischemia by HBO preconditioning.</description><subject>Amitrole - metabolism</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Antioxidants - metabolism</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Catalase - metabolism</subject><subject>Enzyme Inhibitors - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Hyperbaric Oxygenation</subject><subject>Ischemic Preconditioning</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Oxidative Stress</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rabbits</topic><topic>Reperfusion</topic><topic>Spinal Cord Ischemia - metabolism</topic><topic>Spinal Cord Ischemia - prevention & control</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Up-Regulation</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nie, Huang</creatorcontrib><creatorcontrib>Xiong, Lize</creatorcontrib><creatorcontrib>Lao, Ning</creatorcontrib><creatorcontrib>Chen, Shaoyang</creatorcontrib><creatorcontrib>Xu, Ning</creatorcontrib><creatorcontrib>Zhu, Zhenghua</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, Huang</au><au>Xiong, Lize</au><au>Lao, Ning</au><au>Chen, Shaoyang</au><au>Xu, Ning</au><au>Zhu, Zhenghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbaric Oxygen Preconditioning Induces Tolerance against Spinal Cord Ischemia by Upregulation of Antioxidant Enzymes in Rabbits</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>26</volume><issue>5</issue><spage>666</spage><epage>674</epage><pages>666-674</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham pretreatment once daily for five consecutive days before spinal cord ischemia. Activities of catalase (CAT) and superoxide dismutase were increased in spinal cord tissue in the HBO group 24 h after the last pretreatment and reached a higher level after spinal cord ischemia for 20 mins followed by reperfusion for 24 or 48 h, in comparison with those in control and HBA groups. The spinal cord ischemic tolerance induced by HBO preconditioning was attenuated when a CAT inhibitor, 3-amino-1,2,4-triazole,1 g/kg, was administered intraperitoneally 1 h before ischemia. In addition, administration of a free radical scavenger, dimethylthiourea, 500 mg/kg, intravenous, 1 h before each day's preconditioning, reversed the increase of the activities of both enzymes in spinal cord tissue. 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| subjects | Amitrole - metabolism Animals Antihypertensive agents Antioxidants - metabolism Behavior, Animal Biological and medical sciences Cardiovascular system Catalase - metabolism Enzyme Inhibitors - metabolism Glutathione Peroxidase - metabolism Hyperbaric Oxygenation Ischemic Preconditioning Male Malondialdehyde - metabolism Medical sciences Neurology Neurons - metabolism Neuropharmacology Neuroprotective agent Oxidative Stress Pharmacology. Drug treatments Rabbits Reperfusion Spinal Cord Ischemia - metabolism Spinal Cord Ischemia - prevention & control Superoxide Dismutase - metabolism Up-Regulation Vascular diseases and vascular malformations of the nervous system |
| title | Hyperbaric Oxygen Preconditioning Induces Tolerance against Spinal Cord Ischemia by Upregulation of Antioxidant Enzymes in Rabbits |
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