Evaluation of the relationship between inducible nitric oxide synthase (iNOS) activity and effects of melatonin in experimental osteoporosis in the rat

Inducible nitric oxide synthase (iNOS) plays a critical role in the pathogenesis of osteoporosis. iNOS generates nitric oxide (NO), a free radical contributing to the imbalance between bone formation and resorption caused by estrogen depletion. Melatonin is the major product of the pineal gland whic...

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Veröffentlicht in:	Surgical and radiologic anatomy (English ed.) 2006-05, Vol.28 (2), p.157-162
Hauptverfasser:	OKTEM, G, USLU, S, VATANSEVER, S. H, AKTUG, H, YURTSEVEN, M. E, UYSAL, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Animals Antioxidants - pharmacology Apoptosis - drug effects Biological and medical sciences Disease Models, Animal Diseases of the osteoarticular system Female General aspects Growth Plate - cytology Growth Plate - drug effects Growth Plate - metabolism Hormones Immunoenzyme Techniques - methods In Situ Nick-End Labeling - methods Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral Disc - pathology Medical sciences Melatonin - pharmacology Nitric oxide Nitric Oxide Synthase Type II - drug effects Nitric Oxide Synthase Type II - metabolism Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteoporosis Osteoporosis - drug therapy Osteoporosis - metabolism Osteoporosis. Osteomalacia. Paget disease Ovariectomy Rats Rats, Wistar Rodents Sodium Chloride - administration & dosage Time Factors
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