Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study
The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT). Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accepted...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2005-06, Vol.45 (11), p.1753-1756 |
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| container_title | Journal of the American College of Cardiology |
| container_volume | 45 |
| creator | Ajzenberg, Nadine Aubry, Pierre Huisse, Marie-Genevieve Cachier, Agnés El Amara, Walid Feldman, Laurent J Himbert, Dominique Baruch, Dominique Guillin, Marie-Claude Steg, Ph Gabriel |
| description | The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT).
Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accepted platelet function test to identify patients at risk.
We analyzed platelet aggregation in 10 patients who had experienced SAT (cases), 22 stented patients without SAT (controls), and 17 healthy volunteers (normals). All patients except normals were treated with both aspirin and clopidogrel.
Shear-induced platelet aggregation was higher in cases than in controls at both shear rates of 200 s(-1) (40.9 +/- 12.2% vs. 18.2 +/- 18%, p = 0.013) and 4,000 s(-1) (57.4 +/- 16.4% vs. 23.4 +/- 21.2%, p = 0.009). Moreover, SIPA in cases was significantly higher than in normals both at 200 s(-1) (p = 0.013) and 4,000(-1) (p = 0.009).
Shear-induced platelet aggregation is increased in patients experiencing SAT compared with controls receiving dual antiplatelet therapy and to normals receiving no antiplatelet therapy, which suggests increased intrinsic patient-related platelet reactivity in patients with SAT. The predictive value of SIPA for SAT requires prospective investigation. |
| doi_str_mv | 10.1016/j.jacc.2004.10.079 |
| format | Article |
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Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accepted platelet function test to identify patients at risk.
We analyzed platelet aggregation in 10 patients who had experienced SAT (cases), 22 stented patients without SAT (controls), and 17 healthy volunteers (normals). All patients except normals were treated with both aspirin and clopidogrel.
Shear-induced platelet aggregation was higher in cases than in controls at both shear rates of 200 s(-1) (40.9 +/- 12.2% vs. 18.2 +/- 18%, p = 0.013) and 4,000 s(-1) (57.4 +/- 16.4% vs. 23.4 +/- 21.2%, p = 0.009). Moreover, SIPA in cases was significantly higher than in normals both at 200 s(-1) (p = 0.013) and 4,000(-1) (p = 0.009).
Shear-induced platelet aggregation is increased in patients experiencing SAT compared with controls receiving dual antiplatelet therapy and to normals receiving no antiplatelet therapy, which suggests increased intrinsic patient-related platelet reactivity in patients with SAT. The predictive value of SIPA for SAT requires prospective investigation.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2004.10.079</identifier><identifier>PMID: 15936600</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Aged ; Angioplasty, Balloon, Coronary ; Aspirin ; Aspirin - pharmacology ; Aspirin - therapeutic use ; Blood platelets ; Cardiology ; Cardiovascular disease ; Case-Control Studies ; Coronary Disease - therapy ; Coronary vessels ; Drug therapy ; Female ; Heart attacks ; Humans ; Male ; Middle Aged ; Mortality ; Plasma ; Platelet Activation - physiology ; Platelet Aggregation - drug effects ; Platelet Aggregation - physiology ; Platelet Aggregation Inhibitors - pharmacology ; Platelet Aggregation Inhibitors - therapeutic use ; Prospective Studies ; Stents - adverse effects ; Thrombosis ; Thrombosis - physiopathology ; Thrombosis - prevention & control ; Ticlopidine - analogs & derivatives ; Ticlopidine - pharmacology ; Ticlopidine - therapeutic use</subject><ispartof>Journal of the American College of Cardiology, 2005-06, Vol.45 (11), p.1753-1756</ispartof><rights>Copyright Elsevier Limited Jun 7, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15936600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajzenberg, Nadine</creatorcontrib><creatorcontrib>Aubry, Pierre</creatorcontrib><creatorcontrib>Huisse, Marie-Genevieve</creatorcontrib><creatorcontrib>Cachier, Agnés</creatorcontrib><creatorcontrib>El Amara, Walid</creatorcontrib><creatorcontrib>Feldman, Laurent J</creatorcontrib><creatorcontrib>Himbert, Dominique</creatorcontrib><creatorcontrib>Baruch, Dominique</creatorcontrib><creatorcontrib>Guillin, Marie-Claude</creatorcontrib><creatorcontrib>Steg, Ph Gabriel</creatorcontrib><title>Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT).
Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accepted platelet function test to identify patients at risk.
We analyzed platelet aggregation in 10 patients who had experienced SAT (cases), 22 stented patients without SAT (controls), and 17 healthy volunteers (normals). All patients except normals were treated with both aspirin and clopidogrel.
Shear-induced platelet aggregation was higher in cases than in controls at both shear rates of 200 s(-1) (40.9 +/- 12.2% vs. 18.2 +/- 18%, p = 0.013) and 4,000 s(-1) (57.4 +/- 16.4% vs. 23.4 +/- 21.2%, p = 0.009). Moreover, SIPA in cases was significantly higher than in normals both at 200 s(-1) (p = 0.013) and 4,000(-1) (p = 0.009).
Shear-induced platelet aggregation is increased in patients experiencing SAT compared with controls receiving dual antiplatelet therapy and to normals receiving no antiplatelet therapy, which suggests increased intrinsic patient-related platelet reactivity in patients with SAT. The predictive value of SIPA for SAT requires prospective investigation.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Aspirin</subject><subject>Aspirin - pharmacology</subject><subject>Aspirin - therapeutic use</subject><subject>Blood platelets</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Coronary Disease - therapy</subject><subject>Coronary vessels</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Plasma</subject><subject>Platelet Activation - physiology</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation - physiology</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Prospective Studies</subject><subject>Stents - adverse effects</subject><subject>Thrombosis</subject><subject>Thrombosis - physiopathology</subject><subject>Thrombosis - prevention & control</subject><subject>Ticlopidine - analogs & derivatives</subject><subject>Ticlopidine - pharmacology</subject><subject>Ticlopidine - therapeutic use</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxTAQhYMoen38ARcSENz1OmmbpHEnF18guNF1SdPpbS-9SU1SH__eiLpxNefMfAxnhpBTBksGTFxulhttzDIHKFNjCVLtkAXjvMoKruQuWYAseMZAyQNyGMIGAETF1D45YFwVQgAsyNuN7bU12NLQo_bZYNv5202jjjhipHq99rjWcXCWDpZOSaGNgb73juLHhD5ZgzTMjTZzTCKmMY29d9vGhSFcUU2NDpgZZ6N3YwLm9vOY7HV6DHjyW4_Iy-3N8-o-e3y6e1hdP2Z9LouYFcZw5B0Ymauyk1wq2QqTozAKSiMblLJK53cdr0rBu0qUbWkwVygS3LVNcUQufvZO3r3OGGK9HYLBcdQW3RxqIRUAq3gCz_-BGzd7m7LVjINgomQKEnX2S83NFtt68sNW-8_675_FF5Ciel0</recordid><startdate>20050607</startdate><enddate>20050607</enddate><creator>Ajzenberg, Nadine</creator><creator>Aubry, Pierre</creator><creator>Huisse, Marie-Genevieve</creator><creator>Cachier, Agnés</creator><creator>El Amara, Walid</creator><creator>Feldman, Laurent J</creator><creator>Himbert, Dominique</creator><creator>Baruch, Dominique</creator><creator>Guillin, Marie-Claude</creator><creator>Steg, Ph Gabriel</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050607</creationdate><title>Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study</title><author>Ajzenberg, Nadine ; Aubry, Pierre ; Huisse, Marie-Genevieve ; Cachier, Agnés ; El Amara, Walid ; Feldman, Laurent J ; Himbert, Dominique ; Baruch, Dominique ; Guillin, Marie-Claude ; Steg, Ph Gabriel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h273t-3cc5e5f0c7294f75797d6c2e6c904c7be778200ff58465f864d4ce29e6f75fdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Aspirin</topic><topic>Aspirin - pharmacology</topic><topic>Aspirin - therapeutic use</topic><topic>Blood platelets</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Coronary Disease - therapy</topic><topic>Coronary vessels</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Plasma</topic><topic>Platelet Activation - physiology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation - physiology</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Prospective Studies</topic><topic>Stents - adverse effects</topic><topic>Thrombosis</topic><topic>Thrombosis - physiopathology</topic><topic>Thrombosis - prevention & control</topic><topic>Ticlopidine - analogs & derivatives</topic><topic>Ticlopidine - pharmacology</topic><topic>Ticlopidine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ajzenberg, Nadine</creatorcontrib><creatorcontrib>Aubry, Pierre</creatorcontrib><creatorcontrib>Huisse, Marie-Genevieve</creatorcontrib><creatorcontrib>Cachier, Agnés</creatorcontrib><creatorcontrib>El Amara, Walid</creatorcontrib><creatorcontrib>Feldman, Laurent J</creatorcontrib><creatorcontrib>Himbert, Dominique</creatorcontrib><creatorcontrib>Baruch, Dominique</creatorcontrib><creatorcontrib>Guillin, Marie-Claude</creatorcontrib><creatorcontrib>Steg, Ph Gabriel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajzenberg, Nadine</au><au>Aubry, Pierre</au><au>Huisse, Marie-Genevieve</au><au>Cachier, Agnés</au><au>El Amara, Walid</au><au>Feldman, Laurent J</au><au>Himbert, Dominique</au><au>Baruch, Dominique</au><au>Guillin, Marie-Claude</au><au>Steg, Ph Gabriel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2005-06-07</date><risdate>2005</risdate><volume>45</volume><issue>11</issue><spage>1753</spage><epage>1756</epage><pages>1753-1756</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT).
Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accepted platelet function test to identify patients at risk.
We analyzed platelet aggregation in 10 patients who had experienced SAT (cases), 22 stented patients without SAT (controls), and 17 healthy volunteers (normals). All patients except normals were treated with both aspirin and clopidogrel.
Shear-induced platelet aggregation was higher in cases than in controls at both shear rates of 200 s(-1) (40.9 +/- 12.2% vs. 18.2 +/- 18%, p = 0.013) and 4,000 s(-1) (57.4 +/- 16.4% vs. 23.4 +/- 21.2%, p = 0.009). Moreover, SIPA in cases was significantly higher than in normals both at 200 s(-1) (p = 0.013) and 4,000(-1) (p = 0.009).
Shear-induced platelet aggregation is increased in patients experiencing SAT compared with controls receiving dual antiplatelet therapy and to normals receiving no antiplatelet therapy, which suggests increased intrinsic patient-related platelet reactivity in patients with SAT. The predictive value of SIPA for SAT requires prospective investigation.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>15936600</pmid><doi>10.1016/j.jacc.2004.10.079</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Aged Angioplasty, Balloon, Coronary Aspirin Aspirin - pharmacology Aspirin - therapeutic use Blood platelets Cardiology Cardiovascular disease Case-Control Studies Coronary Disease - therapy Coronary vessels Drug therapy Female Heart attacks Humans Male Middle Aged Mortality Plasma Platelet Activation - physiology Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Prospective Studies Stents - adverse effects Thrombosis Thrombosis - physiopathology Thrombosis - prevention & control Ticlopidine - analogs & derivatives Ticlopidine - pharmacology Ticlopidine - therapeutic use |
| title | Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study |
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