Neural Circuitry that Governs Drosophila Male Courtship Behavior
Male-specific fruitless ( fru) products (Fru M) are both necessary and sufficient to “hardwire” the potential for male courtship behavior into the Drosophila nervous system. Fru M is expressed in ∼2% of neurons in the male nervous system, but not in the female. We have targeted the insertion of GAL4...
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| Veröffentlicht in: | Cell 2005-06, Vol.121 (5), p.795-807 |
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| creator | Stockinger, Petra Kvitsiani, Duda Rotkopf, Shay Tirián, László Dickson, Barry J. |
| description | Male-specific
fruitless (
fru) products (Fru
M) are both necessary and sufficient to “hardwire” the potential for male courtship behavior into the
Drosophila nervous system. Fru
M is expressed in ∼2% of neurons in the male nervous system, but not in the female. We have targeted the insertion of
GAL4 into the
fru locus, allowing us to visualize and manipulate the Fru
M-expressing neurons in the male as well as their counterparts in the female. We present evidence that these neurons are directly and specifically involved in male courtship behavior and that at least some of them are interconnected in a circuit. This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent. |
| doi_str_mv | 10.1016/j.cell.2005.04.026 |
| format | Article |
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fruitless (
fru) products (Fru
M) are both necessary and sufficient to “hardwire” the potential for male courtship behavior into the
Drosophila nervous system. Fru
M is expressed in ∼2% of neurons in the male nervous system, but not in the female. We have targeted the insertion of
GAL4 into the
fru locus, allowing us to visualize and manipulate the Fru
M-expressing neurons in the male as well as their counterparts in the female. We present evidence that these neurons are directly and specifically involved in male courtship behavior and that at least some of them are interconnected in a circuit. This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2005.04.026</identifier><identifier>PMID: 15935765</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brain - metabolism ; Drosophila ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Female ; Male ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Neurons - metabolism ; Sex Attractants - metabolism ; Sexual Behavior, Animal ; Smell - physiology ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Cell, 2005-06, Vol.121 (5), p.795-807</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-eaa9a48c944c27aa977e51bafc17a00b76262b49b7657cc139338995aee9fb233</citedby><cites>FETCH-LOGICAL-c429t-eaa9a48c944c27aa977e51bafc17a00b76262b49b7657cc139338995aee9fb233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cell.2005.04.026$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15935765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stockinger, Petra</creatorcontrib><creatorcontrib>Kvitsiani, Duda</creatorcontrib><creatorcontrib>Rotkopf, Shay</creatorcontrib><creatorcontrib>Tirián, László</creatorcontrib><creatorcontrib>Dickson, Barry J.</creatorcontrib><title>Neural Circuitry that Governs Drosophila Male Courtship Behavior</title><title>Cell</title><addtitle>Cell</addtitle><description>Male-specific
fruitless (
fru) products (Fru
M) are both necessary and sufficient to “hardwire” the potential for male courtship behavior into the
Drosophila nervous system. Fru
M is expressed in ∼2% of neurons in the male nervous system, but not in the female. We have targeted the insertion of
GAL4 into the
fru locus, allowing us to visualize and manipulate the Fru
M-expressing neurons in the male as well as their counterparts in the female. We present evidence that these neurons are directly and specifically involved in male courtship behavior and that at least some of them are interconnected in a circuit. This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent.</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Female</subject><subject>Male</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurons - metabolism</subject><subject>Sex Attractants - metabolism</subject><subject>Sexual Behavior, Animal</subject><subject>Smell - physiology</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwBxhQJrYE2_FHLDEAAQpSgQVmy3Evqqu0KXZSqf8eR63EBtPdSc_7SvcgdElwRjARN8vMQtNkFGOeYZZhKo7QmGAlU0YkPUZjjBVNCyHZCJ2FsMQYF5zzUzQiXOVcCj5Gd-_Qe9MkpfO2d53fJd3CdMm03YJfh-TRt6HdLFxjkjfTQFK2ve_Cwm2SB1iYrWv9OTqpTRPg4jAn6Ov56bN8SWcf09fyfpZaRlWXgjHKsMIqxiyV8ZASOKlMbYk0GFdSUEErpuLCpbUkV3leKMUNgKormucTdL3v3fj2u4fQ6ZULw_9mDW0ftJARlwX9FySSC0kEjyDdgzY-GTzUeuPdyvidJlgPgvVSDzk9CNaY6Sg4hq4O7X21gvlv5GA0Ard7AKKMrQOvg3WwtjB3Hmyn5637q_8HAgKLyw</recordid><startdate>20050603</startdate><enddate>20050603</enddate><creator>Stockinger, Petra</creator><creator>Kvitsiani, Duda</creator><creator>Rotkopf, Shay</creator><creator>Tirián, László</creator><creator>Dickson, Barry J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050603</creationdate><title>Neural Circuitry that Governs Drosophila Male Courtship Behavior</title><author>Stockinger, Petra ; 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fruitless (
fru) products (Fru
M) are both necessary and sufficient to “hardwire” the potential for male courtship behavior into the
Drosophila nervous system. Fru
M is expressed in ∼2% of neurons in the male nervous system, but not in the female. We have targeted the insertion of
GAL4 into the
fru locus, allowing us to visualize and manipulate the Fru
M-expressing neurons in the male as well as their counterparts in the female. We present evidence that these neurons are directly and specifically involved in male courtship behavior and that at least some of them are interconnected in a circuit. This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15935765</pmid><doi>10.1016/j.cell.2005.04.026</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell, 2005-06, Vol.121 (5), p.795-807 |
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| source | MEDLINE; Cell Press Archives; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Brain - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Male Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - metabolism Sex Attractants - metabolism Sexual Behavior, Animal Smell - physiology Transcription Factors - genetics Transcription Factors - metabolism |
| title | Neural Circuitry that Governs Drosophila Male Courtship Behavior |
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