Genome-Wide Location of the Coactivator Mediator: Binding without Activation and Transient Cdk8 Interaction on DNA

Mediator is a general coactivator of RNA polymerase II (Pol II) transcription. Genomic location analyses of different Mediator subunits indicate a uniformly composed core complex upstream of active genes but unexpectedly also upstream of inactive genes and on the coding regions of some highly active...

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Veröffentlicht in:	Molecular cell 2006-04, Vol.22 (2), p.179-192
Hauptverfasser:	Andrau, Jean-Christophe, van de Pasch, Loes, Lijnzaad, Philip, Bijma, Theo, Koerkamp, Marian Groot, van de Peppel, Jeroen, Werner, Michel, Holstege, Frank C.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Chromatin Immunoprecipitation Cyclin-Dependent Kinase 8 Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism DNA DNA, Fungal - metabolism DNA, Intergenic Enzyme Activation Fungal Proteins - genetics Fungal Proteins - metabolism Genome, Fungal Models, Biological Nucleic Acid Amplification Techniques Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Promoter Regions, Genetic Protein Binding RNA, Messenger - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Trans-Activators - genetics Trans-Activators - metabolism
Online-Zugang:	Volltext
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