Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase ( SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni
Variation in susceptibility of the snail Biomphalaria glabrata to infection by the parasite Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of super...
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| Veröffentlicht in: | Molecular and biochemical parasitology 2006-06, Vol.147 (2), p.207-210 |
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| container_title | Molecular and biochemical parasitology |
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| creator | Goodall, Cheri P. Bender, Randall C. Brooks, Jana K. Bayne, Christopher J. |
| description | Variation in susceptibility of the snail
Biomphalaria glabrata to infection by the parasite
Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of superoxide dismutase (SOD). The present study identifies alleles of the gene coding for cytosolic copper/zinc SOD (SOD1). The resistance/susceptibility phenotypes and
SOD1 genotypes were determined for 354 snails of the predominantly resistant 13-16-R1 strain of
B. glabrata. Resistance to the parasite was found to be significantly associated with one allele of the
SOD1 gene. Conversely, a separate
SOD1 allele was significantly associated with susceptibility. |
| doi_str_mv | 10.1016/j.molbiopara.2006.02.009 |
| format | Article |
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Biomphalaria glabrata to infection by the parasite
Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of superoxide dismutase (SOD). The present study identifies alleles of the gene coding for cytosolic copper/zinc SOD (SOD1). The resistance/susceptibility phenotypes and
SOD1 genotypes were determined for 354 snails of the predominantly resistant 13-16-R1 strain of
B. glabrata. Resistance to the parasite was found to be significantly associated with one allele of the
SOD1 gene. Conversely, a separate
SOD1 allele was significantly associated with susceptibility.</description><identifier>ISSN: 0166-6851</identifier><identifier>EISSN: 1872-9428</identifier><identifier>DOI: 10.1016/j.molbiopara.2006.02.009</identifier><identifier>PMID: 16564582</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alleles ; Animals ; Biomphalaria - enzymology ; Biomphalaria - immunology ; Biomphalaria - parasitology ; Biomphalaria glabrata ; Copper - metabolism ; Cytosol - enzymology ; Hydrogen peroxide ; Immunity, Innate ; Molecular Sequence Data ; Polymerase Chain Reaction ; Resistance ; Schistosoma mansoni ; Schistosoma mansoni - pathogenicity ; Sequence Analysis, DNA ; Superoxide dismutase ; Superoxide Dismutase - genetics ; Superoxide Dismutase - metabolism ; Zinc - metabolism</subject><ispartof>Molecular and biochemical parasitology, 2006-06, Vol.147 (2), p.207-210</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-6bd05326ee7dd5d688f734d8bcbdd5c95dfb4c95d14178ac82d64c61e7acab303</citedby><cites>FETCH-LOGICAL-c403t-6bd05326ee7dd5d688f734d8bcbdd5c95dfb4c95d14178ac82d64c61e7acab303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molbiopara.2006.02.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16564582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goodall, Cheri P.</creatorcontrib><creatorcontrib>Bender, Randall C.</creatorcontrib><creatorcontrib>Brooks, Jana K.</creatorcontrib><creatorcontrib>Bayne, Christopher J.</creatorcontrib><title>Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase ( SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni</title><title>Molecular and biochemical parasitology</title><addtitle>Mol Biochem Parasitol</addtitle><description>Variation in susceptibility of the snail
Biomphalaria glabrata to infection by the parasite
Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of superoxide dismutase (SOD). The present study identifies alleles of the gene coding for cytosolic copper/zinc SOD (SOD1). The resistance/susceptibility phenotypes and
SOD1 genotypes were determined for 354 snails of the predominantly resistant 13-16-R1 strain of
B. glabrata. Resistance to the parasite was found to be significantly associated with one allele of the
SOD1 gene. Conversely, a separate
SOD1 allele was significantly associated with susceptibility.</description><subject>Alleles</subject><subject>Animals</subject><subject>Biomphalaria - enzymology</subject><subject>Biomphalaria - immunology</subject><subject>Biomphalaria - parasitology</subject><subject>Biomphalaria glabrata</subject><subject>Copper - metabolism</subject><subject>Cytosol - enzymology</subject><subject>Hydrogen peroxide</subject><subject>Immunity, Innate</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Resistance</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - pathogenicity</subject><subject>Sequence Analysis, DNA</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Zinc - metabolism</subject><issn>0166-6851</issn><issn>1872-9428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFDEMhkcIRJfCX0A5ITjMbDIfSZZbP_iSKvVQOEeZxNP1KjMZkgyw_TX8VLLsSj32ZFt-7NfyWxSE0YpRxte7avSuRz_roKuaUl7RuqJ086xYMSnqctPW8nmxyigvuezYWfEqxh2ltBOcvyzOGO9428l6Vfy9RD_OW-10QE3une6DTpqYffLROzTE-HmGsH7AyZC45NT_QQvEYhyXpCOQ9-Tu9pp9IPcwwUdyEaM3qBP6ifjhf4to58BBJL8xbUmAiDHpycA6LtHAnLBHh2lPkid3ZpubWXnUZNRT9BO-Ll4M2kV4c4rnxY_Pn75ffS1vbr98u7q4KU1Lm1Ty3tKuqTmAsLazXMpBNK2VvelzbTadHfr2EFjLhNRG1pa3hjMQ2ui-oc158e64dw7-5wIxqRHzec7pCfwSFRdys-mYfBJkggnB6GGjPIIm-BgDDGoOOOqwV4yqg41qpx5tVAcbFa1VtjGPvj1pLP0I9nHw5FsGLo8A5Jf8QggqGoT8VIsBTFLW49Mq_wCiRLgR</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Goodall, Cheri P.</creator><creator>Bender, Randall C.</creator><creator>Brooks, Jana K.</creator><creator>Bayne, Christopher J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase ( SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni</title><author>Goodall, Cheri P. ; Bender, Randall C. ; Brooks, Jana K. ; Bayne, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-6bd05326ee7dd5d688f734d8bcbdd5c95dfb4c95d14178ac82d64c61e7acab303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Biomphalaria - enzymology</topic><topic>Biomphalaria - immunology</topic><topic>Biomphalaria - parasitology</topic><topic>Biomphalaria glabrata</topic><topic>Copper - metabolism</topic><topic>Cytosol - enzymology</topic><topic>Hydrogen peroxide</topic><topic>Immunity, Innate</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Resistance</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - pathogenicity</topic><topic>Sequence Analysis, DNA</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodall, Cheri P.</creatorcontrib><creatorcontrib>Bender, Randall C.</creatorcontrib><creatorcontrib>Brooks, Jana K.</creatorcontrib><creatorcontrib>Bayne, Christopher J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and biochemical parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodall, Cheri P.</au><au>Bender, Randall C.</au><au>Brooks, Jana K.</au><au>Bayne, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase ( SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni</atitle><jtitle>Molecular and biochemical parasitology</jtitle><addtitle>Mol Biochem Parasitol</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>147</volume><issue>2</issue><spage>207</spage><epage>210</epage><pages>207-210</pages><issn>0166-6851</issn><eissn>1872-9428</eissn><abstract>Variation in susceptibility of the snail
Biomphalaria glabrata to infection by the parasite
Schistosoma mansoni is, at least in part, genetically determined. Functional studies have demonstrated that hemocyte-mediated killing of the parasite involves hydrogen peroxide, the enzymatic product of superoxide dismutase (SOD). The present study identifies alleles of the gene coding for cytosolic copper/zinc SOD (SOD1). The resistance/susceptibility phenotypes and
SOD1 genotypes were determined for 354 snails of the predominantly resistant 13-16-R1 strain of
B. glabrata. Resistance to the parasite was found to be significantly associated with one allele of the
SOD1 gene. Conversely, a separate
SOD1 allele was significantly associated with susceptibility.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16564582</pmid><doi>10.1016/j.molbiopara.2006.02.009</doi><tpages>4</tpages></addata></record> |
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| ispartof | Molecular and biochemical parasitology, 2006-06, Vol.147 (2), p.207-210 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alleles Animals Biomphalaria - enzymology Biomphalaria - immunology Biomphalaria - parasitology Biomphalaria glabrata Copper - metabolism Cytosol - enzymology Hydrogen peroxide Immunity, Innate Molecular Sequence Data Polymerase Chain Reaction Resistance Schistosoma mansoni Schistosoma mansoni - pathogenicity Sequence Analysis, DNA Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Zinc - metabolism |
| title | Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase ( SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni |
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