Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism

Gene transfer to the vessel wall using vascular endothelial growth factors (VEGFs) has shown therapeutic potential for the treatment of restenosis. In this study, we evaluated the effect of catheter-mediated adenoviral (Ad) gene transfer of the mature form of VEGF-D (VEGF-D ΔNΔC ) in balloon-denuded...

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Veröffentlicht in:	Gene therapy 2005-06, Vol.12 (12), p.980-987
Hauptverfasser:	Rutanen, J, Turunen, A-M, Teittinen, M, Rissanen, T T, Heikura, T, Koponen, J K, Gruchala, M, Inkala, M, Jauhiainen, S, Hiltunen, M O, Turunen, M P, Stacker, S A, Achen, M G, Ylä-Herttuala, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Aorta Aortic Diseases - metabolism Aortic Diseases - pathology Aortic Diseases - therapy Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Catheterization Catheters Cell Biology Cholesterol Constriction, Pathologic - therapy Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic Therapy - methods Genetic Vectors - administration & dosage Growth factors Health aspects Health. Pharmaceutical industry Human Genetics Industrial applications and implications. Economical aspects Macrophages Medical sciences mRNA Nanotechnology Neovascularization, Pathologic NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase Physiological aspects Polymerase chain reaction Rabbits Recurrence research-article Restenosis Reverse Transcriptase Polymerase Chain Reaction Risk factors Stenosis Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tunica Intima - metabolism Tunica Intima - pathology Vascular endothelial growth factor Vascular Endothelial Growth Factor D - genetics Vascular Endothelial Growth Factor D - metabolism
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