Iron, Lipids, and Risk of Cancer in the Framingham Offspring Cohort
Iron and lipids combine to create oxidative stress, and oxidative stress has a role in the development of cancer. The objective was to determine the risk of cancer among persons who had both elevated iron and lipids. The authors conducted an analysis of the cohort available in the Framingham Offspri...
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| Veröffentlicht in: | American journal of epidemiology 2005-06, Vol.161 (12), p.1115-1122 |
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| creator | Mainous, Arch G. Wells, Brian J. Koopman, Richelle J. Everett, Charles J. Gill, James M. |
| description | Iron and lipids combine to create oxidative stress, and oxidative stress has a role in the development of cancer. The objective was to determine the risk of cancer among persons who had both elevated iron and lipids. The authors conducted an analysis of the cohort available in the Framingham Offspring Study. Adults aged 30 or more years at baseline had serum iron and high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, and very low density lipoprotein cholesterol (VLDL-C) assessed in 1979–1982 and were followed for development of cancer until 1996–1997 (n = 3,278). Cox regression models were computed while controlling for age, gender, smoking status, and body mass index. In adjusted models, both elevated iron (hazard ratio (HR) = 1.66, 95% confidence interval (CI): 1.11, 2.46; 29 cases) and VLDL-C (HR = 1.54, 95% CI: 1.04, 2.28; 93 cases) had significant independent risks for development of cancer. When elevated iron was combined with elevated VLDL-C, the adjusted relative risk of cancer increased (HR = 2.68, 95% CI: 1.49, 4.83; 18 cases). Elevated iron and low HDL-C also had a significant adjusted relative risk of cancer (HR = 2.82, 95% CI: 1.50, 5.28; 14 cases). The results suggest that elevated serum iron levels coupled with either high VLDL-C or low HDL-C appear to interact to increase cancer risk in this cohort. |
| doi_str_mv | 10.1093/aje/kwi131 |
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The objective was to determine the risk of cancer among persons who had both elevated iron and lipids. The authors conducted an analysis of the cohort available in the Framingham Offspring Study. Adults aged 30 or more years at baseline had serum iron and high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, and very low density lipoprotein cholesterol (VLDL-C) assessed in 1979–1982 and were followed for development of cancer until 1996–1997 (n = 3,278). Cox regression models were computed while controlling for age, gender, smoking status, and body mass index. In adjusted models, both elevated iron (hazard ratio (HR) = 1.66, 95% confidence interval (CI): 1.11, 2.46; 29 cases) and VLDL-C (HR = 1.54, 95% CI: 1.04, 2.28; 93 cases) had significant independent risks for development of cancer. When elevated iron was combined with elevated VLDL-C, the adjusted relative risk of cancer increased (HR = 2.68, 95% CI: 1.49, 4.83; 18 cases). Elevated iron and low HDL-C also had a significant adjusted relative risk of cancer (HR = 2.82, 95% CI: 1.50, 5.28; 14 cases). The results suggest that elevated serum iron levels coupled with either high VLDL-C or low HDL-C appear to interact to increase cancer risk in this cohort.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwi131</identifier><identifier>PMID: 15937020</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Age Distribution ; Aged ; Analysis. Health state ; Biological and medical sciences ; Cancer ; Cohort Studies ; Comorbidity ; confidence interval ; Epidemiology ; General aspects ; hazard ratio ; HDL ; HDL-C ; high density lipoprotein ; high density lipoprotein cholesterol ; Humans ; Incidence ; Iron ; Iron - blood ; LDL ; LDL-C ; Lipids ; Lipids - blood ; low density lipoprotein ; low density lipoprotein cholesterol ; Medical sciences ; Middle Aged ; neoplasms ; Neoplasms - blood ; Neoplasms - epidemiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Sex Distribution ; Smoking - epidemiology ; Survival Analysis ; United States - epidemiology ; very low density lipoprotein ; very low density lipoprotein cholesterol ; VLDL ; VLDL-C</subject><ispartof>American journal of epidemiology, 2005-06, Vol.161 (12), p.1115-1122</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jun 15, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-54b394bde6163eb67fabab7c7da21108141d78abf46d11f3aab381b54c5cdc723</citedby><cites>FETCH-LOGICAL-c447t-54b394bde6163eb67fabab7c7da21108141d78abf46d11f3aab381b54c5cdc723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16968988$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15937020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mainous, Arch G.</creatorcontrib><creatorcontrib>Wells, Brian J.</creatorcontrib><creatorcontrib>Koopman, Richelle J.</creatorcontrib><creatorcontrib>Everett, Charles J.</creatorcontrib><creatorcontrib>Gill, James M.</creatorcontrib><title>Iron, Lipids, and Risk of Cancer in the Framingham Offspring Cohort</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Iron and lipids combine to create oxidative stress, and oxidative stress has a role in the development of cancer. The objective was to determine the risk of cancer among persons who had both elevated iron and lipids. The authors conducted an analysis of the cohort available in the Framingham Offspring Study. Adults aged 30 or more years at baseline had serum iron and high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, and very low density lipoprotein cholesterol (VLDL-C) assessed in 1979–1982 and were followed for development of cancer until 1996–1997 (n = 3,278). Cox regression models were computed while controlling for age, gender, smoking status, and body mass index. In adjusted models, both elevated iron (hazard ratio (HR) = 1.66, 95% confidence interval (CI): 1.11, 2.46; 29 cases) and VLDL-C (HR = 1.54, 95% CI: 1.04, 2.28; 93 cases) had significant independent risks for development of cancer. When elevated iron was combined with elevated VLDL-C, the adjusted relative risk of cancer increased (HR = 2.68, 95% CI: 1.49, 4.83; 18 cases). Elevated iron and low HDL-C also had a significant adjusted relative risk of cancer (HR = 2.82, 95% CI: 1.50, 5.28; 14 cases). The results suggest that elevated serum iron levels coupled with either high VLDL-C or low HDL-C appear to interact to increase cancer risk in this cohort.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>confidence interval</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>hazard ratio</subject><subject>HDL</subject><subject>HDL-C</subject><subject>high density lipoprotein</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Incidence</subject><subject>Iron</subject><subject>Iron - blood</subject><subject>LDL</subject><subject>LDL-C</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>low density lipoprotein</subject><subject>low density lipoprotein cholesterol</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neoplasms</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - epidemiology</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Smoking - epidemiology</subject><subject>Survival Analysis</subject><subject>United States - epidemiology</subject><subject>very low density lipoprotein</subject><subject>very low density lipoprotein cholesterol</subject><subject>VLDL</subject><subject>VLDL-C</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgFrut3vgDJAj2Qjo2J5l8XcrQ2spAoVQQb0Imk7jZ3ZnZJrNU_72RXSx406twyMOB97wIvQXyCYhmF3blL9aPERi8QAuopagE5eIlWhBCaKWpoMfoJOcVIQCak1foGLhmklCyQM1NmsZz3MZt7PM5tmOP72Je4yngxo7OJxxHPC89vkp2iOPPpR3wbQh5m8qAm2k5pfk1Ogp2k_2bw3uKvl1d3jfXVXv75ab53FauruVc8bpjuu56L0Aw3wkZbGc76WRvKQBRUEMvle1CLXqAwKztmIKO14673knKTtHZfu82TQ87n2czxOz8ZmNHP-2yEVJpTTh7FoLkChQTBb7_D66mXRpLCEMZV0xTRgr6uEcuTTknH0wJP9j02wAxfwswpQCzL6Dgd4eNu27w_RM9XLyADwdgs7ObkMqVY35yQgullSqu2ruYZ__r379N65KTSW6uv_8w91Tccd5-NS37A6TTm6A</recordid><startdate>20050615</startdate><enddate>20050615</enddate><creator>Mainous, Arch G.</creator><creator>Wells, Brian J.</creator><creator>Koopman, Richelle J.</creator><creator>Everett, Charles J.</creator><creator>Gill, James M.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7X8</scope></search><sort><creationdate>20050615</creationdate><title>Iron, Lipids, and Risk of Cancer in the Framingham Offspring Cohort</title><author>Mainous, Arch G. ; Wells, Brian J. ; Koopman, Richelle J. ; Everett, Charles J. ; Gill, James M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-54b394bde6163eb67fabab7c7da21108141d78abf46d11f3aab381b54c5cdc723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>confidence interval</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>hazard ratio</topic><topic>HDL</topic><topic>HDL-C</topic><topic>high density lipoprotein</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Incidence</topic><topic>Iron</topic><topic>Iron - blood</topic><topic>LDL</topic><topic>LDL-C</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>low density lipoprotein</topic><topic>low density lipoprotein cholesterol</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neoplasms</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - epidemiology</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Smoking - epidemiology</topic><topic>Survival Analysis</topic><topic>United States - epidemiology</topic><topic>very low density lipoprotein</topic><topic>very low density lipoprotein cholesterol</topic><topic>VLDL</topic><topic>VLDL-C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mainous, Arch G.</creatorcontrib><creatorcontrib>Wells, Brian J.</creatorcontrib><creatorcontrib>Koopman, Richelle J.</creatorcontrib><creatorcontrib>Everett, Charles J.</creatorcontrib><creatorcontrib>Gill, James M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mainous, Arch G.</au><au>Wells, Brian J.</au><au>Koopman, Richelle J.</au><au>Everett, Charles J.</au><au>Gill, James M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron, Lipids, and Risk of Cancer in the Framingham Offspring Cohort</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2005-06-15</date><risdate>2005</risdate><volume>161</volume><issue>12</issue><spage>1115</spage><epage>1122</epage><pages>1115-1122</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Iron and lipids combine to create oxidative stress, and oxidative stress has a role in the development of cancer. The objective was to determine the risk of cancer among persons who had both elevated iron and lipids. The authors conducted an analysis of the cohort available in the Framingham Offspring Study. Adults aged 30 or more years at baseline had serum iron and high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, and very low density lipoprotein cholesterol (VLDL-C) assessed in 1979–1982 and were followed for development of cancer until 1996–1997 (n = 3,278). Cox regression models were computed while controlling for age, gender, smoking status, and body mass index. In adjusted models, both elevated iron (hazard ratio (HR) = 1.66, 95% confidence interval (CI): 1.11, 2.46; 29 cases) and VLDL-C (HR = 1.54, 95% CI: 1.04, 2.28; 93 cases) had significant independent risks for development of cancer. When elevated iron was combined with elevated VLDL-C, the adjusted relative risk of cancer increased (HR = 2.68, 95% CI: 1.49, 4.83; 18 cases). Elevated iron and low HDL-C also had a significant adjusted relative risk of cancer (HR = 2.82, 95% CI: 1.50, 5.28; 14 cases). The results suggest that elevated serum iron levels coupled with either high VLDL-C or low HDL-C appear to interact to increase cancer risk in this cohort.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>15937020</pmid><doi>10.1093/aje/kwi131</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Age Distribution Aged Analysis. Health state Biological and medical sciences Cancer Cohort Studies Comorbidity confidence interval Epidemiology General aspects hazard ratio HDL HDL-C high density lipoprotein high density lipoprotein cholesterol Humans Incidence Iron Iron - blood LDL LDL-C Lipids Lipids - blood low density lipoprotein low density lipoprotein cholesterol Medical sciences Middle Aged neoplasms Neoplasms - blood Neoplasms - epidemiology Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Sex Distribution Smoking - epidemiology Survival Analysis United States - epidemiology very low density lipoprotein very low density lipoprotein cholesterol VLDL VLDL-C |
| title | Iron, Lipids, and Risk of Cancer in the Framingham Offspring Cohort |
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