Targeting epigenetic regulatory mechanisms in cancer chemoprevention
Dysregulation of the epigenome plays a fundamental role in tumour development. Epigenetic events are a major mechanism for inactivating tumour suppressor and DNA repair genes and occur ubiquitously during the early stages of tumour development. Unlike genes inactivated by mutation, genes silenced ep...
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| Veröffentlicht in: | Expert opinion on therapeutic targets 2005-04, Vol.9 (2), p.315-328 |
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| container_title | Expert opinion on therapeutic targets |
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| creator | Fay, Judith R Crowell, James A Kopelovich, Levy |
| description | Dysregulation of the epigenome plays a fundamental role in tumour development. Epigenetic events are a major mechanism for inactivating tumour suppressor and DNA repair genes and occur ubiquitously during the early stages of tumour development. Unlike genes inactivated by mutation, genes silenced epigenetically are intact and potentially responsive to reactivation by small molecules. This review discusses the potential for restoring epige-netic balance as a means to prevent cancer. |
| doi_str_mv | 10.1517/14728222.9.2.315 |
| format | Article |
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Epigenetic events are a major mechanism for inactivating tumour suppressor and DNA repair genes and occur ubiquitously during the early stages of tumour development. Unlike genes inactivated by mutation, genes silenced epigenetically are intact and potentially responsive to reactivation by small molecules. 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Epigenetic events are a major mechanism for inactivating tumour suppressor and DNA repair genes and occur ubiquitously during the early stages of tumour development. Unlike genes inactivated by mutation, genes silenced epigenetically are intact and potentially responsive to reactivation by small molecules. This review discusses the potential for restoring epige-netic balance as a means to prevent cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>cancer</subject><subject>chemoprevention</subject><subject>DNA methylation</subject><subject>Drug Delivery Systems - methods</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>Epigenesis, Genetic - physiology</subject><subject>epigenetics</subject><subject>histone modification</subject><subject>Humans</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - physiopathology</subject><subject>Neoplasms - prevention & control</subject><issn>1472-8222</issn><issn>1744-7631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAUhYMovveupCt3HfNom0ZX4hsEN7oOt-ntTKRNxqRV5t8bmRFx4eoeOA8uHyEnjM5YyeQ5KySvOeczNeMzwcotss9kUeSyEmw76WTn3_4eOYjxjVJOVVntkj1WKlEoVu-TmxcIcxytm2e4tHN0SZss4HzqYfRhlQ1oFuBsHGJmXWbAGQyZWeDglwE_0I3WuyOy00Ef8XhzD8nr3e3L9UP-9Hz_eH31lJuC0jHnlNVtaSh0vGjKVphGqg5Ey7hoWION4pVpqko0IJWRpoKKoqKqbmuoRQudOCRn691l8O8TxlEPNhrse3Dop6grWau6lCwF6Tpogo8xYKeXwQ4QVppR_U1O_5DTSnOdyKXK6WZ7agZsfwsbVClwuQ5Y1_kwwKcPfatHWPU-dCFxsTEN_T9_8ae9QOjHhYGA-s1PwSVs___2BXPRkHA</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Fay, Judith R</creator><creator>Crowell, James A</creator><creator>Kopelovich, Levy</creator><general>Ashley Publications Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Targeting epigenetic regulatory mechanisms in cancer chemoprevention</title><author>Fay, Judith R ; Crowell, James A ; Kopelovich, Levy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-2018d5c0af24b5d3cb79fa3d123b1beb926cb663ba79c7c6a60e9098d8a83daf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>cancer</topic><topic>chemoprevention</topic><topic>DNA methylation</topic><topic>Drug Delivery Systems - methods</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>Epigenesis, Genetic - physiology</topic><topic>epigenetics</topic><topic>histone modification</topic><topic>Humans</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - physiopathology</topic><topic>Neoplasms - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fay, Judith R</creatorcontrib><creatorcontrib>Crowell, James A</creatorcontrib><creatorcontrib>Kopelovich, Levy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Expert opinion on therapeutic targets</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fay, Judith R</au><au>Crowell, James A</au><au>Kopelovich, Levy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting epigenetic regulatory mechanisms in cancer chemoprevention</atitle><jtitle>Expert opinion on therapeutic targets</jtitle><addtitle>Expert Opin Ther Targets</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>9</volume><issue>2</issue><spage>315</spage><epage>328</epage><pages>315-328</pages><issn>1472-8222</issn><eissn>1744-7631</eissn><abstract>Dysregulation of the epigenome plays a fundamental role in tumour development. 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| ispartof | Expert opinion on therapeutic targets, 2005-04, Vol.9 (2), p.315-328 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use cancer chemoprevention DNA methylation Drug Delivery Systems - methods Epigenesis, Genetic - drug effects Epigenesis, Genetic - physiology epigenetics histone modification Humans Neoplasms - genetics Neoplasms - physiopathology Neoplasms - prevention & control |
| title | Targeting epigenetic regulatory mechanisms in cancer chemoprevention |
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