Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase...
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| Veröffentlicht in: | Life sciences (1973) 2005-07, Vol.77 (7), p.721-734 |
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| container_title | Life sciences (1973) |
| container_volume | 77 |
| creator | Yue, Kevin K.M. Leung, Sze-nga Man, Po-mei Yeung, Wing-fai Chung, Wai-shing Lee, Kin-wah Leung, Albert W.N. Cheng, Christopher H.K. |
| description | Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues. |
| doi_str_mv | 10.1016/j.lfs.2004.10.081 |
| format | Article |
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In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2004.10.081</identifier><identifier>PMID: 15936347</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antioxidant enzymes ; Aorta - metabolism ; Blood Glucose ; Catalase - metabolism ; Diabetes Mellitus, Experimental - enzymology ; Diabetes Mellitus, Experimental - physiopathology ; Diabetic complications ; Eye - metabolism ; Glutathione Peroxidase - metabolism ; Kidney - metabolism ; Male ; Oxidative stress ; Oxidative Stress - physiology ; Oxidoreductases - metabolism ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase - metabolism ; Time Factors</subject><ispartof>Life sciences (1973), 2005-07, Vol.77 (7), p.721-734</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-89a67b6ce3071c52553c694d720d17ab834df79dd94330708c947eaf17baa81a3</citedby><cites>FETCH-LOGICAL-c351t-89a67b6ce3071c52553c694d720d17ab834df79dd94330708c947eaf17baa81a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320505002663$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15936347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yue, Kevin K.M.</creatorcontrib><creatorcontrib>Leung, Sze-nga</creatorcontrib><creatorcontrib>Man, Po-mei</creatorcontrib><creatorcontrib>Yeung, Wing-fai</creatorcontrib><creatorcontrib>Chung, Wai-shing</creatorcontrib><creatorcontrib>Lee, Kin-wah</creatorcontrib><creatorcontrib>Leung, Albert W.N.</creatorcontrib><creatorcontrib>Cheng, Christopher H.K.</creatorcontrib><title>Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.</description><subject>Animals</subject><subject>Antioxidant enzymes</subject><subject>Aorta - metabolism</subject><subject>Blood Glucose</subject><subject>Catalase - metabolism</subject><subject>Diabetes Mellitus, Experimental - enzymology</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetic complications</subject><subject>Eye - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Oxidoreductases - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Time Factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOxCAUhonR6Hh5ADeGlSs7QmlLiStjvCUmbnRNKJxGxk6rHGbi-AA-t3RmEneuDpDv_074CTnlbMoZry5n067Fac5Yke5TVvMdMuG1VBmrBN8lE8byIhM5Kw_IIeKMMVaWUuyTA14qUYlCTsjPdRchmOiHHqnvqenT8cu7NCn036s5UGOjX_roYQ3EN6CwArygZgjRpICj7971sEI6tNR500D0liYn0gAdLEdVHNbBtATiiK1XJC1QjAEQj8leazqEk-08Iq93ty83D9nT8_3jzfVTZkXJY1YrU8mmsiCY5LbMy1LYShVO5sxxaZpaFK6VyjlViISw2qpCgmm5bIypuRFH5Hzj_QjD5wIw6rlHC11nehgWqCtZK6kqlUC-AW0YEAO0-iP4uQkrzZkey9czncrXY_njUyo_Zc628kUzB_eX2LadgKsNAOmLSw9Bo_XQW3A-gI3aDf4f_S-DWJdC</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Yue, Kevin K.M.</creator><creator>Leung, Sze-nga</creator><creator>Man, Po-mei</creator><creator>Yeung, Wing-fai</creator><creator>Chung, Wai-shing</creator><creator>Lee, Kin-wah</creator><creator>Leung, Albert W.N.</creator><creator>Cheng, Christopher H.K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress</title><author>Yue, Kevin K.M. ; Leung, Sze-nga ; Man, Po-mei ; Yeung, Wing-fai ; Chung, Wai-shing ; Lee, Kin-wah ; Leung, Albert W.N. ; Cheng, Christopher H.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-89a67b6ce3071c52553c694d720d17ab834df79dd94330708c947eaf17baa81a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antioxidant enzymes</topic><topic>Aorta - metabolism</topic><topic>Blood Glucose</topic><topic>Catalase - metabolism</topic><topic>Diabetes Mellitus, Experimental - enzymology</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetic complications</topic><topic>Eye - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Oxidoreductases - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yue, Kevin K.M.</creatorcontrib><creatorcontrib>Leung, Sze-nga</creatorcontrib><creatorcontrib>Man, Po-mei</creatorcontrib><creatorcontrib>Yeung, Wing-fai</creatorcontrib><creatorcontrib>Chung, Wai-shing</creatorcontrib><creatorcontrib>Lee, Kin-wah</creatorcontrib><creatorcontrib>Leung, Albert W.N.</creatorcontrib><creatorcontrib>Cheng, Christopher H.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yue, Kevin K.M.</au><au>Leung, Sze-nga</au><au>Man, Po-mei</au><au>Yeung, Wing-fai</au><au>Chung, Wai-shing</au><au>Lee, Kin-wah</au><au>Leung, Albert W.N.</au><au>Cheng, Christopher H.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>77</volume><issue>7</issue><spage>721</spage><epage>734</epage><pages>721-734</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>15936347</pmid><doi>10.1016/j.lfs.2004.10.081</doi><tpages>14</tpages></addata></record> |
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| ispartof | Life sciences (1973), 2005-07, Vol.77 (7), p.721-734 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antioxidant enzymes Aorta - metabolism Blood Glucose Catalase - metabolism Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - physiopathology Diabetic complications Eye - metabolism Glutathione Peroxidase - metabolism Kidney - metabolism Male Oxidative stress Oxidative Stress - physiology Oxidoreductases - metabolism Rats Rats, Sprague-Dawley Superoxide Dismutase - metabolism Time Factors |
| title | Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress |
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