Polymorphism in the tissue factor region is associated with basal but not endotoxin‐induced tissue factor‐mRNA levels in leukocytes

Objective: Tissue factor (TF) plays a central role during disseminated intravascular coagulation (DIC) in sepsis. We hypothesized that a frequent D/I polymorphism, at nucleotide position −1208 in the promoter region, could influence TF‐mRNA and downstream coagulation. Methods: Basal‐ and lipopolysac...

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